39. S. Nie, S.R. Emory, Probing single molecules and single nanoparticles by surface-enhanced
Raman scattering. Science 275, 1102–1106 (1997)
40. M. Vendrell, K.K. Maiti, K. Dhaliwal, Y.T. Chang, Surface-enhanced Raman scattering in
cancer detection and imaging. Trends Biotechnol. 31, 249–257 (2013)
41. J.W. Chan, D.S. Taylor, T. Zwerdling, S.M. Lane, K. Ihara, T. Huser, Micro-Raman
spectroscopy detects individual neoplastic and normal hematopoietic cells. Biophys. J. 90,
648–656 (2006)
42. J.W. Chan, D.S. Taylor, S.M. Lane, T. Zwerdling, J. Tuscano, T. Huser, Nondestructive
identification of individual leukemia cells by laser trapping Raman spectroscopy. Anal. Chem.
80, 2180–2187 (2008)
43. K. Das, N. Stone, C. Kendall, C. Fowler, J. Christie-Brown, Raman spectroscopy of
parathyroid tissue pathology. Lasers Med. Sci. 21, 192–197 (2006)
44. B.W. de Jong, T.C. Schut, K. Maquelin, T. van der Kwast, C.H. Bangma, D.J. Kok et al.,
Discrimination between nontumor bladder tissue and tumor by Raman spectroscopy. Anal.
Chem. 78, 7761–7769 (2006)
45. M.V. Chowdary, K.K. Kumar, J. Kurien, S. Mathew, C.M. Krishna, Discrimination of
normal, benign, and malignant breast tissues by Raman spectroscopy. Biopolymers 83, 556–
569 (2006)
46. C.A. Lieber, S.K. Majumder, D.L. Ellis, D.D. Billheimer, A. Mahadevan-Jansen, In vivo
nonmelanoma skin cancer diagnosis using Raman microspectroscopy. Lasers Surg. Med. 40,
461–467 (2008)
47. A. Nijssen, K. Maquelin, L.F. Santos, P.J. Caspers, T.C. Bakker Schut, J.C. den Hollander
et al., Discriminating basal cell carcinoma from perilesional skin using high wave-number
Raman spectroscopy. J. Biomed. Opt. 12, 034004 (2007)
48. J.T. Motz, S.J. Gandhi, O.R. Scepanovic, A.S. Haka, J.R. Kramer, R.R. Dasari et al.,
Real-time Raman system for in vivo disease diagnosis. J. Biomed. Opt. 10, 031113 (2005)
49. J.T. Motz, M. Fitzmaurice, A. Miller, S.J. Gandhi, A.S. Haka, L.H. Galindo et al., In vivo
Raman spectral pathology of human atherosclerosis and vulnerable plaque. J. Biomed. Opt.
11, 021003 (2006)
50. A.S. Haka, Z. Volynskaya, J.A. Gardecki, J. Nazemi, J. Lyons, D. Hicks et al., In vivo margin
assessment during partial mastectomy breast surgery using raman spectroscopy. Cancer Res.
66, 3317–3322 (2006)
51. K. Peremans, B. Cornelissen, B. Van Den Bossche, K. Audenaert, C. Van de Wiele, A review
of small animal imaging planar and pinhole spect Gamma camera imaging. Vet. Radiol.
Ultrasound. 46, 162–170 (2005)
52. S. Xue, C. Zhang, Y. Yang, L. Zhang, D. Cheng, J. Zhang et al.,
99m
Tc-labeled iron oxide
nanoparticles for dual-contrast (T1/T2) magnetic resonance and dual-modality imaging of
tumor angiogenesis. J. Biomed. Nanotechnol. 11, 1027–1037 (2015)
53. E. Locatelli, M. Naddaka, C. Uboldi, G. Loudos, E. Fragogeorgi, V. Molinari et al., Targeted
delivery of silver nanoparticles and alisertib: in vitro and in vivo synergistic effect against
glioblastoma. Nanomedicine (Lond). 9, 839–849 (2014)
54. E. Morales-Avila, G. Ferro-Flores, B.E. Ocampo-Garcia, L.M. De Leon-Rodriguez, C.L.
Santos-Cuevas, R. Garcia-Becerra et al., Multimeric system of
99m
Tc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor alpha(v)beta(3) expression.
Bioconjug. Chem. 22, 913–922 (2011)
55. M. Tsuchimochi, K. Hayama, M. Toyama, I. Sasagawa, N. Tsubokawa, Dual-modality
imaging with 99mTc and fluorescent indocyanine green using surface-modified silica
nanoparticles for biopsy of the sentinel lymph node: an animal study. EJNMMI Res. 3, 33
(2013)
56. Y. Seo, C.M. Aparici, C.P. Chen, C. Hsu, N. Kased, C. Schreck et al., Mapping of lymphatic
drainage from the prostate using filtered
99m
Tc-sulfur nanocolloid and SPECT/CT. J. Nucl.
Med. 52, 1068–1072 (2011)
22 Molecular Imaging Using Radionanomedicine
427
Raman scattering. Science 275, 1102–1106 (1997)
40. M. Vendrell, K.K. Maiti, K. Dhaliwal, Y.T. Chang, Surface-enhanced Raman scattering in
cancer detection and imaging. Trends Biotechnol. 31, 249–257 (2013)
41. J.W. Chan, D.S. Taylor, T. Zwerdling, S.M. Lane, K. Ihara, T. Huser, Micro-Raman
spectroscopy detects individual neoplastic and normal hematopoietic cells. Biophys. J. 90,
648–656 (2006)
42. J.W. Chan, D.S. Taylor, S.M. Lane, T. Zwerdling, J. Tuscano, T. Huser, Nondestructive
identification of individual leukemia cells by laser trapping Raman spectroscopy. Anal. Chem.
80, 2180–2187 (2008)
43. K. Das, N. Stone, C. Kendall, C. Fowler, J. Christie-Brown, Raman spectroscopy of
parathyroid tissue pathology. Lasers Med. Sci. 21, 192–197 (2006)
44. B.W. de Jong, T.C. Schut, K. Maquelin, T. van der Kwast, C.H. Bangma, D.J. Kok et al.,
Discrimination between nontumor bladder tissue and tumor by Raman spectroscopy. Anal.
Chem. 78, 7761–7769 (2006)
45. M.V. Chowdary, K.K. Kumar, J. Kurien, S. Mathew, C.M. Krishna, Discrimination of
normal, benign, and malignant breast tissues by Raman spectroscopy. Biopolymers 83, 556–
569 (2006)
46. C.A. Lieber, S.K. Majumder, D.L. Ellis, D.D. Billheimer, A. Mahadevan-Jansen, In vivo
nonmelanoma skin cancer diagnosis using Raman microspectroscopy. Lasers Surg. Med. 40,
461–467 (2008)
47. A. Nijssen, K. Maquelin, L.F. Santos, P.J. Caspers, T.C. Bakker Schut, J.C. den Hollander
et al., Discriminating basal cell carcinoma from perilesional skin using high wave-number
Raman spectroscopy. J. Biomed. Opt. 12, 034004 (2007)
48. J.T. Motz, S.J. Gandhi, O.R. Scepanovic, A.S. Haka, J.R. Kramer, R.R. Dasari et al.,
Real-time Raman system for in vivo disease diagnosis. J. Biomed. Opt. 10, 031113 (2005)
49. J.T. Motz, M. Fitzmaurice, A. Miller, S.J. Gandhi, A.S. Haka, L.H. Galindo et al., In vivo
Raman spectral pathology of human atherosclerosis and vulnerable plaque. J. Biomed. Opt.
11, 021003 (2006)
50. A.S. Haka, Z. Volynskaya, J.A. Gardecki, J. Nazemi, J. Lyons, D. Hicks et al., In vivo margin
assessment during partial mastectomy breast surgery using raman spectroscopy. Cancer Res.
66, 3317–3322 (2006)
51. K. Peremans, B. Cornelissen, B. Van Den Bossche, K. Audenaert, C. Van de Wiele, A review
of small animal imaging planar and pinhole spect Gamma camera imaging. Vet. Radiol.
Ultrasound. 46, 162–170 (2005)
52. S. Xue, C. Zhang, Y. Yang, L. Zhang, D. Cheng, J. Zhang et al.,
99m
Tc-labeled iron oxide
nanoparticles for dual-contrast (T1/T2) magnetic resonance and dual-modality imaging of
tumor angiogenesis. J. Biomed. Nanotechnol. 11, 1027–1037 (2015)
53. E. Locatelli, M. Naddaka, C. Uboldi, G. Loudos, E. Fragogeorgi, V. Molinari et al., Targeted
delivery of silver nanoparticles and alisertib: in vitro and in vivo synergistic effect against
glioblastoma. Nanomedicine (Lond). 9, 839–849 (2014)
54. E. Morales-Avila, G. Ferro-Flores, B.E. Ocampo-Garcia, L.M. De Leon-Rodriguez, C.L.
Santos-Cuevas, R. Garcia-Becerra et al., Multimeric system of
99m
Tc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor alpha(v)beta(3) expression.
Bioconjug. Chem. 22, 913–922 (2011)
55. M. Tsuchimochi, K. Hayama, M. Toyama, I. Sasagawa, N. Tsubokawa, Dual-modality
imaging with 99mTc and fluorescent indocyanine green using surface-modified silica
nanoparticles for biopsy of the sentinel lymph node: an animal study. EJNMMI Res. 3, 33
(2013)
56. Y. Seo, C.M. Aparici, C.P. Chen, C. Hsu, N. Kased, C. Schreck et al., Mapping of lymphatic
drainage from the prostate using filtered
99m
Tc-sulfur nanocolloid and SPECT/CT. J. Nucl.
Med. 52, 1068–1072 (2011)
22 Molecular Imaging Using Radionanomedicine
427