Table 19.1
(continued)
Nanoparticle
core
Surface coating
Core size/
HD
Strategy
Animal model
Imaging
Quantification Renal
clearance
References
124
I–cRGD–PEG500 NR/6.8
Ultrasmall
core + PEGylation
Athymic nude
mice
PET
Gamma
counting
72%ID
in 72 h
[12]
Gd-Carbon dots
ZW800-PET1500
and
64
Cu–DOTA–
PEG
NR/12
Unknown
Nude mice
MRI
None
NR
[13]
Porous silica
nanoparticle
NR
NR/126
Biodegradable NP
BALB/c
Fluorescence NR
NR
[14]
Carbon nanotube
86
Y–DOTA(AF488)
(AF680)
200–300
High aspect ratio
Nude mouse
PET
PET
T
1/2 :
6 min
[15]
500–2000 High aspect ratio
BALB/c
TEM
None
NR
[16]
NP nanoparticle,
HD hydrodynamic diameter,
SD Sprague Dawley,
ID injected dose,
RGD Arginylglycylaspartic acid.
GPI (2-[((3-amino-3-carboxypropyl)
(hydroxy)phosphinyl)-methyl]pentane-1,5-dioic acid,
GSH glutathione,
CT computed tomography,
ICP–MS Inductively coupled plasma mass spectrometry,
SPECT single photon emission computed tomography,
DTDTPA dithiolated diethylenetriamine pentaacetic acid,
NR not reported,
NOTA
1,4,7-triazacyclononane-triacetic acid,
DOTA 1,4,7,10-tetraazacyclododecane-tetraacetic acid,
FA folic acid,
PET positron emission tomography,
TEM
transmission electron microscopy. Modified and reproduced with permission [60]
352
H.-J. Im
(continued)
Nanoparticle
core
Surface coating
Core size/
HD
Strategy
Animal model
Imaging
Quantification Renal
clearance
References
124
I–cRGD–PEG500 NR/6.8
Ultrasmall
core + PEGylation
Athymic nude
mice
PET
Gamma
counting
72%ID
in 72 h
[12]
Gd-Carbon dots
ZW800-PET1500
and
64
Cu–DOTA–
PEG
NR/12
Unknown
Nude mice
MRI
None
NR
[13]
Porous silica
nanoparticle
NR
NR/126
Biodegradable NP
BALB/c
Fluorescence NR
NR
[14]
Carbon nanotube
86
Y–DOTA(AF488)
(AF680)
200–300
High aspect ratio
Nude mouse
PET
PET
T
1/2 :
6 min
[15]
500–2000 High aspect ratio
BALB/c
TEM
None
NR
[16]
NP nanoparticle,
HD hydrodynamic diameter,
SD Sprague Dawley,
ID injected dose,
RGD Arginylglycylaspartic acid.
GPI (2-[((3-amino-3-carboxypropyl)
(hydroxy)phosphinyl)-methyl]pentane-1,5-dioic acid,
GSH glutathione,
CT computed tomography,
ICP–MS Inductively coupled plasma mass spectrometry,
SPECT single photon emission computed tomography,
DTDTPA dithiolated diethylenetriamine pentaacetic acid,
NR not reported,
NOTA
1,4,7-triazacyclononane-triacetic acid,
DOTA 1,4,7,10-tetraazacyclododecane-tetraacetic acid,
FA folic acid,
PET positron emission tomography,
TEM
transmission electron microscopy. Modified and reproduced with permission [60]
352
H.-J. Im