10.4 Concluding Remarks
Over the past two decades, radionanomaterials have attracted a lot of attentions thus
the concept of ‘radionanomedicines’ is also rapidly formed. Surface engineering is
very critical for the quality of radionanomaterials for biomedical applications. There
is certainly no single perfect method for successful surface modification of radionanomaterials, but here in this chapter our goal is to categorize these surface
modification strategies and illustrate how to prepare these radionanomaterials into
multifunctional nanoplatform for theranostic (diagnostic/therapy) applications.
A lot of further optimization will still be needed before radionanomaterials can
serve as radionanomedicines clinically. We hope that this chapter can provide some
insights into future development of new radionanomedicines and possible further
optimization of current existing ones.
References
1. S. Hajiw, J. Schmitt, M. Imperor-Clerc, B. Pansu, Solvent-driven interactions between
hydrophobically-coated nanoparticles. Soft Matter 11(19), 3920–3926 (2015)
2. M. Muthiah, I.K. Park, C.S. Cho, Surface modification of iron oxide nanoparticles by
biocompatible polymers for tissue imaging and targeting. Biotechnol. Adv. 31(8), 1224–
1236 (2013)
3. A.A. D’Souza, R. Shegokar, Polyethylene glycol (PEG): a versatile polymer for
pharmaceutical applications. Expert Opin. Drug Deliv. 13(9), 1257–1275 (2016)
4. Y. Chen, Y. Xianyu, X. Jiang, Surface modification of gold nanoparticles with small
molecules for biochemical analysis. Acc. Chem. Res. 50(2), 310–319 (2017)
5. X.S. Zheng, P. Hu, Y. Cui, C. Zong, J.M. Feng, X. Wang et al., BSA-coated nanoparticles
for improved SERS-based intracellular pH sensing. Anal. Chem. 86(24), 12250–12257
(2014)
6. L. Liu, X. Li, L. Chen, X. Zhang, Nanoscale functional biomaterials for cancer theranostics.
Curr. Med. Chem. (2017) (Epub)
7. A.M. Dias, A. Hussain, A.S. Marcos, A.C. Roque, A biotechnological perspective on the
application of iron oxide magnetic colloids modified with polysaccharides. Biotechnol. Adv.
29(1), 142–155 (2011)
8. S. Shi, F. Chen, W. Cai, Biomedical applications of functionalized hollow mesoporous silica
nanoparticles: focusing on molecular imaging. Nanomedicine 8(12), 2027–2039 (2013)
9. S.B. Lee, S.W. Lee, S.Y. Jeong, G. Yoon, S.J. Cho, S.K. Kim et al., Engineering of
radioiodine-labeled gold core-shell nanoparticles as efficient nuclear medicine imaging
agents for trafficking of dendritic cells. ACS Appl. Mater. Interfaces 9(10), 8480–8489
(2017)
10. N. Feliu, D. Docter, M. Heine, P. Del Pino, S. Ashraf, J. Kolosnjaj-Tabi et al., In vivo
degeneration and the fate of inorganic nanoparticles. Chem. Soc. Rev. 45(9), 2440–2457
(2016)
11. T. Cedervall, I. Lynch, S. Lindman, T. Berggard, E. Thulin, H. Nilsson et al., Understanding
the nanoparticle-protein corona using methods to quantify exchange rates and affinities of
proteins for nanoparticles. Proc. Nat. Acad. Sci. U S A 104(7), 2050–2055 (2007)
200
D. Chen and H. Hong
Over the past two decades, radionanomaterials have attracted a lot of attentions thus
the concept of ‘radionanomedicines’ is also rapidly formed. Surface engineering is
very critical for the quality of radionanomaterials for biomedical applications. There
is certainly no single perfect method for successful surface modification of radionanomaterials, but here in this chapter our goal is to categorize these surface
modification strategies and illustrate how to prepare these radionanomaterials into
multifunctional nanoplatform for theranostic (diagnostic/therapy) applications.
A lot of further optimization will still be needed before radionanomaterials can
serve as radionanomedicines clinically. We hope that this chapter can provide some
insights into future development of new radionanomedicines and possible further
optimization of current existing ones.
References
1. S. Hajiw, J. Schmitt, M. Imperor-Clerc, B. Pansu, Solvent-driven interactions between
hydrophobically-coated nanoparticles. Soft Matter 11(19), 3920–3926 (2015)
2. M. Muthiah, I.K. Park, C.S. Cho, Surface modification of iron oxide nanoparticles by
biocompatible polymers for tissue imaging and targeting. Biotechnol. Adv. 31(8), 1224–
1236 (2013)
3. A.A. D’Souza, R. Shegokar, Polyethylene glycol (PEG): a versatile polymer for
pharmaceutical applications. Expert Opin. Drug Deliv. 13(9), 1257–1275 (2016)
4. Y. Chen, Y. Xianyu, X. Jiang, Surface modification of gold nanoparticles with small
molecules for biochemical analysis. Acc. Chem. Res. 50(2), 310–319 (2017)
5. X.S. Zheng, P. Hu, Y. Cui, C. Zong, J.M. Feng, X. Wang et al., BSA-coated nanoparticles
for improved SERS-based intracellular pH sensing. Anal. Chem. 86(24), 12250–12257
(2014)
6. L. Liu, X. Li, L. Chen, X. Zhang, Nanoscale functional biomaterials for cancer theranostics.
Curr. Med. Chem. (2017) (Epub)
7. A.M. Dias, A. Hussain, A.S. Marcos, A.C. Roque, A biotechnological perspective on the
application of iron oxide magnetic colloids modified with polysaccharides. Biotechnol. Adv.
29(1), 142–155 (2011)
8. S. Shi, F. Chen, W. Cai, Biomedical applications of functionalized hollow mesoporous silica
nanoparticles: focusing on molecular imaging. Nanomedicine 8(12), 2027–2039 (2013)
9. S.B. Lee, S.W. Lee, S.Y. Jeong, G. Yoon, S.J. Cho, S.K. Kim et al., Engineering of
radioiodine-labeled gold core-shell nanoparticles as efficient nuclear medicine imaging
agents for trafficking of dendritic cells. ACS Appl. Mater. Interfaces 9(10), 8480–8489
(2017)
10. N. Feliu, D. Docter, M. Heine, P. Del Pino, S. Ashraf, J. Kolosnjaj-Tabi et al., In vivo
degeneration and the fate of inorganic nanoparticles. Chem. Soc. Rev. 45(9), 2440–2457
(2016)
11. T. Cedervall, I. Lynch, S. Lindman, T. Berggard, E. Thulin, H. Nilsson et al., Understanding
the nanoparticle-protein corona using methods to quantify exchange rates and affinities of
proteins for nanoparticles. Proc. Nat. Acad. Sci. U S A 104(7), 2050–2055 (2007)
200
D. Chen and H. Hong