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radiolabeling with I-131 and tissue uptake studies in “naïve” nude mice. J. Nucl. Med. 57
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63. S. Vallabhajosula, D. Lyden, H.P. Selgas, A. Nikolopoulou, Radiolabeled exosomes for the
early detection of metastases and to predict breast cancer premetastatic niche: Annual rept.
1 Aug 2014–31 Jul 2015 Cornell University Medical Coll
64. D.S. Lee, C. Hongyoon, Y.S. Lee, J.M. Jeong, Y.S Gho, S.C. Jang SC, Method for labeling
exosomes with radioactive substance and use thereof. Google Patents, 2015
65. Y. Takahashi, M. Nishikawa, H. Shinotsuka, Y. Matsui, S. Ohara, T. Imai et al., Visualization
and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after
intravenous injection. J. Biotechnol. 165(2), 77–84 (2013)
66. T. Imai, Y. Takahashi, M. Nishikawa, K. Kato, M. Morishita, T. Yamashita et al.,
Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes
from the blood circulation in mice. J. Extracell Vesicles 4(1), 26238 (2015)
67. V. Hornung, F. Bauernfeind, A. Halle, E.O. Samstad, H. Kono, K.L. Rock et al., Silica
crystals and aluminum salts activate the NALP3 inflammasome through phagosomal
destabilization. Nat. Immunol. 9(8), 847–856 (2008)
68. O.P. Wiklander, J.Z. Nordin, A. O’Loughlin, Y. Gustafsson, G. Corso, I. Mäger et al.,
Extracellular vesicle in vivo biodistribution is determined by cell source, route of
administration and targeting. Extracell Vesicles 4(1), 26316 (2015)
182
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