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e285 (2017)
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48. G. Zhuang, X. Wu, Z. Jiang, I. Kasman, J. Yao, Y. Guan et al., Tumour-secreted miR-9
promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J. 31(17), 3513–3523 (2012)
49. A. Hoshino, B. Costa-Silva, T.L. Shen, G. Rodrigues, A. Hashimoto, M. Tesic Mark et al.,
Tumour exosome integrins determine organotropic metastasis. Nature 527(7578), 329–335
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50. B. Costa-Silva, N.M. Aiello, A.J. Ocean, S. Singh, H. Zhang, B.K. Thakur et al., Pancreatic
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mediators of extracellular communication during cancer progression. J. Cell Sci. 123(Pt 10),
1603–1611 (2010)
33. S.J. Gould, G. Raposo, As we wait: coping with an imperfect nomenclature for extracellular
vesicles. J. Extracell Vesicles. 2, 20389 (2013)
34. J. Conde-Vancells, E. Rodriguez-Suarez, N. Embade, D. Gil, R. Matthiesen, M. Valle et al.,
Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes.
J. Proteome Res. 7(12), 5157–5166 (2008)
35. T.L. Whiteside, Exosomes and tumor-mediated immune suppression. J. Clin. Invest. 126(4),
1216–1223 (2016)
36. C. Ciardiello, L. Cavallini, C. Spinelli, J. Yang, M. Reis-Sobreiro, P. de Candia et al., Focus
on extracellular vesicles: new frontiers of cell-to-cell communication in cancer. Int. J. Mol.
Sci. 17(2), 175 (2016)
37. M. Szajnik, M. Czystowska, M.J. Szczepanski, M. Mandapathil, T.L. Whiteside,
Tumor-derived microvesicles induce, expand and up-regulate biological activities of human
regulatory T cells (Treg). PLoS One 5(7), e11469 (2010)
38. A. Clayton, J.P. Mitchell, J. Court, S. Linnane, M.D. Mason, Z. Tabi, Human tumor-derived
exosomes down-modulate NKG2D expression. J Immunol. 180(11), 7249–7258 (2008)
39. A. Clayton, S. Al-Taei, J. Webber, M.D. Mason, Z. Tabi, Cancer exosomes express CD39 and
CD73, which suppress T cells through adenosine production. J. Immunol. 187(2), 676–683
(2011)
40. P.J. Schuler, Z. Saze, C.S. Hong, L. Muller, D.G. Gillespie, D. Cheng et al., Human
CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73 or
contact with CD73 + exosomes or CD73 + cells. Clin. Exp. Immunol. 177(2), 531–543
(2014)
41. M.T. Le, P. Hamar, C. Guo, E. Basar, R. Perdigao-Henriques, L. Balaj et al.,
miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J. Clin.
Invest. 124(12), 5109–5128 (2014)
42. N. Kosaka, H. Iguchi, K. Hagiwara, Y. Yoshioka, F. Takeshita, T. Ochiya, Neutral
sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs
regulate cancer cell metastasis. J. Biol. Chem. 288(15), 10849–10859 (2013)
43. M. Demory Beckler, J.N. Higginbotham, J.L. Franklin, A.J. Ham, P.J. Halvey, I.E. Imasuen
et al., Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies
intercellular transfer of mutant KRAS. Mol. Cell. Proteomics 12(2), 343–355 (2013)
44. J. Webber, R. Steadman, M.D. Mason, Z. Tabi, A. Clayton, Cancer exosomes trigger
fibroblast to myofibroblast differentiation. Cancer Res. 70(23), 9621–9630 (2010)
45. M. Tomasetti, W. Lee, L. Santarelli, J. Neuzil, Exosome-derived microRNAs in cancer
metabolism: possible implications in cancer diagnostics and therapy. Exp. Mol. Med. 49(1),
e285 (2017)
46. X. Zhang, X. Yuan, H. Shi, L. Wu, H. Qian, W. Xu, Exosomes in cancer: small particle, big
player. J. Hematol. Oncol. 8, 83 (2015)
47. B.M. Lopes-Bastos, W.G. Jiang, J. Cai, Tumour-endothelial cell communications: important
and indispensable mediators of tumour angiogenesis. Anticancer Res. 36(3), 1119–1126
(2016)
48. G. Zhuang, X. Wu, Z. Jiang, I. Kasman, J. Yao, Y. Guan et al., Tumour-secreted miR-9
promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J. 31(17), 3513–3523 (2012)
49. A. Hoshino, B. Costa-Silva, T.L. Shen, G. Rodrigues, A. Hashimoto, M. Tesic Mark et al.,
Tumour exosome integrins determine organotropic metastasis. Nature 527(7578), 329–335
(2015)
50. B. Costa-Silva, N.M. Aiello, A.J. Ocean, S. Singh, H. Zhang, B.K. Thakur et al., Pancreatic
cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17(6),
816–826 (2015)
138
C. Lee et al.