10. D.K. Kim, B. Kang, O.Y. Kim, D.S. Choi, J. Lee, S.R. Kim et al. EVpedia: an integrated
database of high-throughput data for systemic analyses of extracellular vesicles. J. Extracell
Vesicles 2 (2013)
11. D.K. Kim, J. Lee, S.R. Kim, D.S. Choi, Y.J. Yoon, J.H. Kim et al., EVpedia: a community
web portal for extracellular vesicles research. Bioinformatics 31(6), 933–939 (2015)
12. E. Chargaff, R. West, The biological significance of the thromboplastic protein of blood.
J. Biol. Chem. 166(1), 189–197 (1946)
13. P. Wolf, The nature and significance of platelet products in human plasma. Br. J. Haematol.
13(3), 269–288 (1967)
14. H.C. Anderson, Vesicles associated with calcification in the matrix of epiphyseal cartilage.
J. Cell Biol. 41(1), 59–72 (1969)
15. B. Stegmayr, G. Ronquist, Promotive effect on human sperm progressive motility by
prostasomes. Urol. Res. 10(5), 253–257 (1982)
16. G. Ronquist, I. Brody, A. Gottfries, B. Stegmayr, An Mg
2+ and Ca
2+ —stimulated adenosine
triphosphatase in human prostatic fluid–part II. Andrologia 10(6), 427–433 (1978)
17. H.F. Dvorak, S.C. Quay, N.S. Orenstein, A.M. Dvorak, P. Hahn, A.M. Bitzer et al., Tumor
shedding and coagulation. Science 212(4497), 923–924 (1981)
18. C. Harding, J. Heuser, P. Stahl, Endocytosis and intracellular processing of transferrin and
colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor
shedding. Eur. J. Cell Biol. 35(2), 256–263 (1984)
19. R.M. Johnstone, M. Adam, J.R. Hammond, L. Orr, C. Turbide, Vesicle formation during
reticulocyte maturation. Association of plasma membrane activities with released vesicles
(exosomes). J. Biol. Chem. 262(19), 9412–9420 (1987)
20. G. Raposo, H.W. Nijman, W. Stoorvogel, R. Liejendekker, C.V. Harding, C.J. Melief et al.,
B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183(3), 1161–1172 (1996)
21. C.W. Kim, H.M. Lee, T.H. Lee, C. Kang, H.K. Kleinman, Y.S. Gho, Extracellular membrane
vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res. 62(21),
6312–6317 (2002)
22. H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J.J. Lee, J.O. Lotvall, Exosome-mediated
transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat. Cell Biol. 9(6), 654–659 (2007)
23. M.P. Hunter, N. Ismail, X. Zhang, B.D. Aguda, E.J. Lee, L. Yu et al., Detection of microRNA
expression in human peripheral blood microvesicles. PLoS One 3(11), e3694 (2008)
24. J. Ratajczak, K. Miekus, M. Kucia, J. Zhang, R. Reca, P. Dvorak et al., Embryonic stem
cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal
transfer of mRNA and protein delivery. Leukemia 20(5), 847–856 (2006)
25. J. Skog, T. Wurdinger, S. van Rijn, D.H. Meijer, L. Gainche, M. Sena-Esteves et al.,
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and
provide diagnostic biomarkers. Nat. Cell Biol. 10(12), 1470–1476 (2008)
26. E.N. Nolte-’t Hoen, M. Waasdorp, W. Stoorvogel, M.H. Wauben, P.A. t Hoen, Deep
sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation
of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Res. 40
(18), 9272–9285 (2012)
27. M. Colombo, G. Raposo, C. Thery, Biogenesis, secretion, and intercellular interactions of
exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014)
28. G. Raposo, W. Stoorvogel, Extracellular vesicles: exosomes, microvesicles, and friends.
J. Cell Biol. 200(4), 373–383 (2013)
29. M. Simons, G. Raposo, Exosomes–vesicular carriers for intercellular communication. Curr.
Opin. Cell Biol. 21(4), 575–581 (2009)
30. R.J. Simpson, S.S. Jensen, J.W. Lim, Proteomic profiling of exosomes: current perspectives.
Proteomics 8(19), 4083–4099 (2008)
31. C. Thery, M. Ostrowski, E. Segura, Membrane vesicles as conveyors of immune responses.
Nat. Rev. Immunol. 9(8), 581–593 (2009)
6 Endogenous Radionanomedicine: Extracellular Vesicles
137
database of high-throughput data for systemic analyses of extracellular vesicles. J. Extracell
Vesicles 2 (2013)
11. D.K. Kim, J. Lee, S.R. Kim, D.S. Choi, Y.J. Yoon, J.H. Kim et al., EVpedia: a community
web portal for extracellular vesicles research. Bioinformatics 31(6), 933–939 (2015)
12. E. Chargaff, R. West, The biological significance of the thromboplastic protein of blood.
J. Biol. Chem. 166(1), 189–197 (1946)
13. P. Wolf, The nature and significance of platelet products in human plasma. Br. J. Haematol.
13(3), 269–288 (1967)
14. H.C. Anderson, Vesicles associated with calcification in the matrix of epiphyseal cartilage.
J. Cell Biol. 41(1), 59–72 (1969)
15. B. Stegmayr, G. Ronquist, Promotive effect on human sperm progressive motility by
prostasomes. Urol. Res. 10(5), 253–257 (1982)
16. G. Ronquist, I. Brody, A. Gottfries, B. Stegmayr, An Mg
2+ and Ca
2+ —stimulated adenosine
triphosphatase in human prostatic fluid–part II. Andrologia 10(6), 427–433 (1978)
17. H.F. Dvorak, S.C. Quay, N.S. Orenstein, A.M. Dvorak, P. Hahn, A.M. Bitzer et al., Tumor
shedding and coagulation. Science 212(4497), 923–924 (1981)
18. C. Harding, J. Heuser, P. Stahl, Endocytosis and intracellular processing of transferrin and
colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor
shedding. Eur. J. Cell Biol. 35(2), 256–263 (1984)
19. R.M. Johnstone, M. Adam, J.R. Hammond, L. Orr, C. Turbide, Vesicle formation during
reticulocyte maturation. Association of plasma membrane activities with released vesicles
(exosomes). J. Biol. Chem. 262(19), 9412–9420 (1987)
20. G. Raposo, H.W. Nijman, W. Stoorvogel, R. Liejendekker, C.V. Harding, C.J. Melief et al.,
B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183(3), 1161–1172 (1996)
21. C.W. Kim, H.M. Lee, T.H. Lee, C. Kang, H.K. Kleinman, Y.S. Gho, Extracellular membrane
vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res. 62(21),
6312–6317 (2002)
22. H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J.J. Lee, J.O. Lotvall, Exosome-mediated
transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat. Cell Biol. 9(6), 654–659 (2007)
23. M.P. Hunter, N. Ismail, X. Zhang, B.D. Aguda, E.J. Lee, L. Yu et al., Detection of microRNA
expression in human peripheral blood microvesicles. PLoS One 3(11), e3694 (2008)
24. J. Ratajczak, K. Miekus, M. Kucia, J. Zhang, R. Reca, P. Dvorak et al., Embryonic stem
cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal
transfer of mRNA and protein delivery. Leukemia 20(5), 847–856 (2006)
25. J. Skog, T. Wurdinger, S. van Rijn, D.H. Meijer, L. Gainche, M. Sena-Esteves et al.,
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and
provide diagnostic biomarkers. Nat. Cell Biol. 10(12), 1470–1476 (2008)
26. E.N. Nolte-’t Hoen, M. Waasdorp, W. Stoorvogel, M.H. Wauben, P.A. t Hoen, Deep
sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation
of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Res. 40
(18), 9272–9285 (2012)
27. M. Colombo, G. Raposo, C. Thery, Biogenesis, secretion, and intercellular interactions of
exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014)
28. G. Raposo, W. Stoorvogel, Extracellular vesicles: exosomes, microvesicles, and friends.
J. Cell Biol. 200(4), 373–383 (2013)
29. M. Simons, G. Raposo, Exosomes–vesicular carriers for intercellular communication. Curr.
Opin. Cell Biol. 21(4), 575–581 (2009)
30. R.J. Simpson, S.S. Jensen, J.W. Lim, Proteomic profiling of exosomes: current perspectives.
Proteomics 8(19), 4083–4099 (2008)
31. C. Thery, M. Ostrowski, E. Segura, Membrane vesicles as conveyors of immune responses.
Nat. Rev. Immunol. 9(8), 581–593 (2009)
6 Endogenous Radionanomedicine: Extracellular Vesicles
137