51. P. Vader, X.O. Breakefield, M.J. Wood, Extracellular vesicles: emerging targets for cancer
therapy. Trends Mol. Med. 20(7), 385–393 (2014)
52. A. Thind, C. Wilson, Exosomal miRNAs as cancer biomarkers and therapeutic targets.
J. Extracell Vesicles. 5, 31292 (2016)
53. A. Sharma, Z. Khatun, A. Shiras, Tumor exosomes: cellular postmen of cancer diagnosis and
personalized therapy. Nanomedicine Lond. 11(4), 421–437 (2016)
54. M. Hosseini, S. Khatamianfar, S.M. Hassanian, R. Nedaeinia, M. Shafiee, M. Maftouh et al.,
Exosome-encapsulated microRNAs as potential circulating biomarkers in colon cancer. Curr.
Pharm. Des. 23(11), 1705–1709 (2017)
55. S.N. Hurwitz, M.A. Rider, J.L. Bundy, X. Liu, R.K. Singh, D.G. Meckes Jr., Proteomic
profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer
type-specific biomarkers. Oncotarget 7(52), 86999–87015 (2016)
56. X. Zhou, W. Wen, X. Shan, W. Zhu, J. Xu, R. Guo et al., A six-microRNA panel in plasma
was identified as a potential biomarker for lung adenocarcinoma diagnosis. Oncotarget 8(4),
6513–6525 (2017)
57. Y. Tanaka, H. Kamohara, K. Kinoshita, J. Kurashige, T. Ishimoto, M. Iwatsuki et al., Clinical
impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal
squamous cell carcinoma. Cancer 119(6), 1159–1167 (2013)
58. M. Verma, T.K. Lam, E. Hebert, R.L. Divi, Extracellular vesicles: potential applications in
cancer diagnosis, prognosis, and epidemiology. BMC Clin. Pathol. 15, 6 (2015)
59. L. Alvarez-Erviti, Y. Seow, H. Yin, C. Betts, S. Lakhal, M.J. Wood, Delivery of siRNA to the
mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29(4), 341–345
(2011)
60. T.A. Shtam, R.A. Kovalev, E.Y. Varfolomeeva, E.M. Makarov, Y.V. Kil, M.V. Filatov,
Exosomes are natural carriers of exogenous siRNA to human cells in vitro. Cell Commun.
Signal. 11, 88 (2013)
61. M.C. Deregibus, V. Cantaluppi, R. Calogero, M. Lo Iacono, C. Tetta, L. Biancone et al.,
Endothelial progenitor cell derived microvesicles activate an angiogenic program in
endothelial cells by a horizontal transfer of mRNA. Blood 110(7), 2440–2448 (2007)
62. S. Ela, I. Mager, X.O. Breakefield, M.J. Wood, Extracellular vesicles: biology and emerging
therapeutic opportunities. Nat. Rev. Drug Discov. 12(5), 347–357 (2013)
63. S. Gatti, S. Bruno, M.C. Deregibus, A. Sordi, V. Cantaluppi, C. Tetta et al., Microvesicles
derived
from
human
adult
mesenchymal
stem
cells
protect
against
ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol. Dial. Transplant.
26(5), 1474–1483 (2011)
64. M.B. Herrera, V. Fonsato, S. Gatti, M.C. Deregibus, A. Sordi, D. Cantarella et al., Human
liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats.
J. Cell Mol. Med. 14(6B), 1605–1618 (2010)
65. C. Lee, S.A. Mitsialis, M. Aslam, S.H. Vitali, E. Vergadi, G. Konstantinou et al., Exosomes
mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced
pulmonary hypertension. Circulation 126(22), 2601–2611 (2012)
66. R.C. Lai, F. Arslan, M.M. Lee, N.S. Sze, A. Choo, T.S. Chen et al., Exosome secreted by
MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 4(3), 214–222 (2010)
67. S. Bruno, C. Grange, M.C. Deregibus, R.A. Calogero, S. Saviozzi, F. Collino et al.,
Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J. Am.
Soc. Nephrol. 20(5), 1053–1067 (2009)
68. J. Kim, C. Han, W. Jo, S. Kang, S. Cho, D. Jeong et al., Cell-engineered nanovesicle as a
surrogate inducer of contact-dependent stimuli. Adv. Healthc. Mater. 6(17) (2017)
69. S.C. Jang, O.Y. Kim, C.M. Yoon, D.S. Choi, T.Y. Roh, J. Park et al., Bioinspired
exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant
tumors. ACS Nano. 7(9), 7698–7710 (2013)
70. S.C. Jang, Y.S. Gho, Could bioengineered exosome-mimetic nanovesicles be an efficient
strategy for the delivery of chemotherapeutics? Nanomed. Lond. 9(2), 177–180 (2014)
6 Endogenous Radionanomedicine: Extracellular Vesicles
139
therapy. Trends Mol. Med. 20(7), 385–393 (2014)
52. A. Thind, C. Wilson, Exosomal miRNAs as cancer biomarkers and therapeutic targets.
J. Extracell Vesicles. 5, 31292 (2016)
53. A. Sharma, Z. Khatun, A. Shiras, Tumor exosomes: cellular postmen of cancer diagnosis and
personalized therapy. Nanomedicine Lond. 11(4), 421–437 (2016)
54. M. Hosseini, S. Khatamianfar, S.M. Hassanian, R. Nedaeinia, M. Shafiee, M. Maftouh et al.,
Exosome-encapsulated microRNAs as potential circulating biomarkers in colon cancer. Curr.
Pharm. Des. 23(11), 1705–1709 (2017)
55. S.N. Hurwitz, M.A. Rider, J.L. Bundy, X. Liu, R.K. Singh, D.G. Meckes Jr., Proteomic
profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer
type-specific biomarkers. Oncotarget 7(52), 86999–87015 (2016)
56. X. Zhou, W. Wen, X. Shan, W. Zhu, J. Xu, R. Guo et al., A six-microRNA panel in plasma
was identified as a potential biomarker for lung adenocarcinoma diagnosis. Oncotarget 8(4),
6513–6525 (2017)
57. Y. Tanaka, H. Kamohara, K. Kinoshita, J. Kurashige, T. Ishimoto, M. Iwatsuki et al., Clinical
impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal
squamous cell carcinoma. Cancer 119(6), 1159–1167 (2013)
58. M. Verma, T.K. Lam, E. Hebert, R.L. Divi, Extracellular vesicles: potential applications in
cancer diagnosis, prognosis, and epidemiology. BMC Clin. Pathol. 15, 6 (2015)
59. L. Alvarez-Erviti, Y. Seow, H. Yin, C. Betts, S. Lakhal, M.J. Wood, Delivery of siRNA to the
mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29(4), 341–345
(2011)
60. T.A. Shtam, R.A. Kovalev, E.Y. Varfolomeeva, E.M. Makarov, Y.V. Kil, M.V. Filatov,
Exosomes are natural carriers of exogenous siRNA to human cells in vitro. Cell Commun.
Signal. 11, 88 (2013)
61. M.C. Deregibus, V. Cantaluppi, R. Calogero, M. Lo Iacono, C. Tetta, L. Biancone et al.,
Endothelial progenitor cell derived microvesicles activate an angiogenic program in
endothelial cells by a horizontal transfer of mRNA. Blood 110(7), 2440–2448 (2007)
62. S. Ela, I. Mager, X.O. Breakefield, M.J. Wood, Extracellular vesicles: biology and emerging
therapeutic opportunities. Nat. Rev. Drug Discov. 12(5), 347–357 (2013)
63. S. Gatti, S. Bruno, M.C. Deregibus, A. Sordi, V. Cantaluppi, C. Tetta et al., Microvesicles
derived
from
human
adult
mesenchymal
stem
cells
protect
against
ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol. Dial. Transplant.
26(5), 1474–1483 (2011)
64. M.B. Herrera, V. Fonsato, S. Gatti, M.C. Deregibus, A. Sordi, D. Cantarella et al., Human
liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats.
J. Cell Mol. Med. 14(6B), 1605–1618 (2010)
65. C. Lee, S.A. Mitsialis, M. Aslam, S.H. Vitali, E. Vergadi, G. Konstantinou et al., Exosomes
mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced
pulmonary hypertension. Circulation 126(22), 2601–2611 (2012)
66. R.C. Lai, F. Arslan, M.M. Lee, N.S. Sze, A. Choo, T.S. Chen et al., Exosome secreted by
MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 4(3), 214–222 (2010)
67. S. Bruno, C. Grange, M.C. Deregibus, R.A. Calogero, S. Saviozzi, F. Collino et al.,
Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J. Am.
Soc. Nephrol. 20(5), 1053–1067 (2009)
68. J. Kim, C. Han, W. Jo, S. Kang, S. Cho, D. Jeong et al., Cell-engineered nanovesicle as a
surrogate inducer of contact-dependent stimuli. Adv. Healthc. Mater. 6(17) (2017)
69. S.C. Jang, O.Y. Kim, C.M. Yoon, D.S. Choi, T.Y. Roh, J. Park et al., Bioinspired
exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant
tumors. ACS Nano. 7(9), 7698–7710 (2013)
70. S.C. Jang, Y.S. Gho, Could bioengineered exosome-mimetic nanovesicles be an efficient
strategy for the delivery of chemotherapeutics? Nanomed. Lond. 9(2), 177–180 (2014)
6 Endogenous Radionanomedicine: Extracellular Vesicles
139