Reski R, Parsons J, Decker EL (2015) Moss-made pharmaceuticals: from bench to bedside. Plant
Biotechnol J 13(8):1191–1198. https://doi.org/10.1111/pbi.12401
Rios-Huerta R, Monreal-Escalante E, Govea-Alonso DO, Angulo C, Rosales-Mendoza S (2017)
Expression of an immunogenic LTB-based chimeric protein targeting Zaire ebolavirus
epitopes from GP1 in plant cells. Plant Cell Rep 36:355–365. https://doi.org/10.1007/s00299016-2088-6
Rodriguez M, Ramirez NI, Ayala M, Freyre F, Pérez L, Triguero A, Mateo C, Selman-Housein G,
Gavilondo JV, Pujol M (2005) Transient expression in tobacco leaves of an aglycosylated
recombinant antibody against the epidermal growth factor receptor. Biotechnol Bioeng
89(2):188–194. https://doi.org/10.1002/bit.20333
Rubio-Infante N, Govea-Alonso DO, Romero-Maldonado A, García-Hernández AL,
Ilhuicatzi-Alvarado D, Salazar-González JA, Korban SS, Rosales-Mendoza S,
Moreno-Fierros L (2015) A plant-derived multi-HIV antigen induces broad immune responses
in orally immunized mice. Mol Biotechnol 57(7):662–674. https://doi.org/10.1007/s12033-0159856-3
Rukavtsova EB, Rudenko NV, Puchko EN, Zakharchenko NS, Buryanov YI (2015) Study of the
immunogenicity of hepatitis B surface antigen synthesized in transgenic potato plants with
increased biosafety. J Biotechnol 203:84–88. https://doi.org/10.1016/j.jbiotec.2015.03.019
Rybicki EP (2010) Plant-made vaccines for humans and animals. Plant Biotechnol J 8(5):620–637.
https://doi.org/10.1111/j.1467-7652.2010.00507.x
Rybicki EP (2014) Plant-based vaccines against viruses. Virol J 11:205–225. https://doi.org/10.
1186/s12985-014-0205-0
Sabalza M, Vamvaka E, Christou P, Capell T (2013) Seeds as a production system for molecular
pharming applications: status and prospects. Curr Pharm Des 19(31):5543–5552
Sainsbury F, Thuenemann EC, Lomonossoff GP (2009) pEAQ: versatile expression vectors
for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol J
7(7):682–693. https://doi.org/10.1111/j.1467-7652.2009.00434.x
Sainsbury F, Sack M, Stadlmann J, Quendler H, Fischer R, Lomonossoff GP (2010) Rapid transient
production in plants by replicating and non-replicating vectors yields high quality functional
anti-HIV antibody. PLoS One 5(11):e13976. https://doi.org/10.1371/journal.pone.0013976
Salazar-González JA, Angulo C, Rosales-Mendoza S (2015) Chikungunya virus vaccines: current
strategies and prospects for developing plant-made vaccines. Vaccine 33(31):3650–3658.
https://doi.org/10.1016/j.vaccine.2015.05.104
Santos RB, Abranches R, Fischer R, Sack M, Holland T (2016) Putting the spotlight back on plant
suspension cultures. Front Plant Sci 7:60–72. https://doi.org/10.3389/fpls.2016.00297
Sarrion-Perdigones A, Falconi EE, Zandalinas SI, Juárez P, Fernández-del-Carmen A, Granell A,
Orzaez D (2011) GoldenBraid: an iterative cloning system for standardized assembly of
reusable genetic modules. PLoS One 6(7):e21622. https://doi.org/10.1371/journal.pone.
0021622
Schillberg S, Raven N, Fischer R, Twyman RM, Schiermeyer A (2013) Molecular farming
of pharmaceutical proteins using plant suspension cell and tissue cultures. Curr Pharm Des
19(31):5531–5542
Scotti N, Rybicki EP (2013) Virus-like particles produced in plants as potential vaccines. Expert
Rev Vaccines 12(2):211–224. https://doi.org/10.1586/erv.12.147
Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky
SA, Silman I, Sussman JL, Futerman AH, Aviezer D (2007) Production of glucocerebrosidase
with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a
plant cell system. Plant Biotechnol J 5(5):579–590. https://doi.org/10.1111/j.1467-7652.2007.
00263.x
Shaaltiel Y, Gingis-Velitski S, Tzaban S, Fiks N, Tekoah Y, Aviezer D (2015) Plant-based
oral delivery of β-glucocerebrosidase as an enzyme replacement therapy for Gaucher's disease.
Plant Biotechnol J 13(8):1033–1040. https://doi.org/10.1111/pbi.12366
Engineering Plants for the Future: Farming with Value-Added Harvest
105
Biotechnol J 13(8):1191–1198. https://doi.org/10.1111/pbi.12401
Rios-Huerta R, Monreal-Escalante E, Govea-Alonso DO, Angulo C, Rosales-Mendoza S (2017)
Expression of an immunogenic LTB-based chimeric protein targeting Zaire ebolavirus
epitopes from GP1 in plant cells. Plant Cell Rep 36:355–365. https://doi.org/10.1007/s00299016-2088-6
Rodriguez M, Ramirez NI, Ayala M, Freyre F, Pérez L, Triguero A, Mateo C, Selman-Housein G,
Gavilondo JV, Pujol M (2005) Transient expression in tobacco leaves of an aglycosylated
recombinant antibody against the epidermal growth factor receptor. Biotechnol Bioeng
89(2):188–194. https://doi.org/10.1002/bit.20333
Rubio-Infante N, Govea-Alonso DO, Romero-Maldonado A, García-Hernández AL,
Ilhuicatzi-Alvarado D, Salazar-González JA, Korban SS, Rosales-Mendoza S,
Moreno-Fierros L (2015) A plant-derived multi-HIV antigen induces broad immune responses
in orally immunized mice. Mol Biotechnol 57(7):662–674. https://doi.org/10.1007/s12033-0159856-3
Rukavtsova EB, Rudenko NV, Puchko EN, Zakharchenko NS, Buryanov YI (2015) Study of the
immunogenicity of hepatitis B surface antigen synthesized in transgenic potato plants with
increased biosafety. J Biotechnol 203:84–88. https://doi.org/10.1016/j.jbiotec.2015.03.019
Rybicki EP (2010) Plant-made vaccines for humans and animals. Plant Biotechnol J 8(5):620–637.
https://doi.org/10.1111/j.1467-7652.2010.00507.x
Rybicki EP (2014) Plant-based vaccines against viruses. Virol J 11:205–225. https://doi.org/10.
1186/s12985-014-0205-0
Sabalza M, Vamvaka E, Christou P, Capell T (2013) Seeds as a production system for molecular
pharming applications: status and prospects. Curr Pharm Des 19(31):5543–5552
Sainsbury F, Thuenemann EC, Lomonossoff GP (2009) pEAQ: versatile expression vectors
for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol J
7(7):682–693. https://doi.org/10.1111/j.1467-7652.2009.00434.x
Sainsbury F, Sack M, Stadlmann J, Quendler H, Fischer R, Lomonossoff GP (2010) Rapid transient
production in plants by replicating and non-replicating vectors yields high quality functional
anti-HIV antibody. PLoS One 5(11):e13976. https://doi.org/10.1371/journal.pone.0013976
Salazar-González JA, Angulo C, Rosales-Mendoza S (2015) Chikungunya virus vaccines: current
strategies and prospects for developing plant-made vaccines. Vaccine 33(31):3650–3658.
https://doi.org/10.1016/j.vaccine.2015.05.104
Santos RB, Abranches R, Fischer R, Sack M, Holland T (2016) Putting the spotlight back on plant
suspension cultures. Front Plant Sci 7:60–72. https://doi.org/10.3389/fpls.2016.00297
Sarrion-Perdigones A, Falconi EE, Zandalinas SI, Juárez P, Fernández-del-Carmen A, Granell A,
Orzaez D (2011) GoldenBraid: an iterative cloning system for standardized assembly of
reusable genetic modules. PLoS One 6(7):e21622. https://doi.org/10.1371/journal.pone.
0021622
Schillberg S, Raven N, Fischer R, Twyman RM, Schiermeyer A (2013) Molecular farming
of pharmaceutical proteins using plant suspension cell and tissue cultures. Curr Pharm Des
19(31):5531–5542
Scotti N, Rybicki EP (2013) Virus-like particles produced in plants as potential vaccines. Expert
Rev Vaccines 12(2):211–224. https://doi.org/10.1586/erv.12.147
Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky
SA, Silman I, Sussman JL, Futerman AH, Aviezer D (2007) Production of glucocerebrosidase
with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a
plant cell system. Plant Biotechnol J 5(5):579–590. https://doi.org/10.1111/j.1467-7652.2007.
00263.x
Shaaltiel Y, Gingis-Velitski S, Tzaban S, Fiks N, Tekoah Y, Aviezer D (2015) Plant-based
oral delivery of β-glucocerebrosidase as an enzyme replacement therapy for Gaucher's disease.
Plant Biotechnol J 13(8):1033–1040. https://doi.org/10.1111/pbi.12366
Engineering Plants for the Future: Farming with Value-Added Harvest
105