Olinger GG Jr, Pettitt J, Kim D, Working C, Bohorov O, Bratcher B, Hiatt E, Hume SD,
Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L,
Zeitlin L (2012) Delayed treatment of Ebola virus infection with plant-derived monoclonal
antibodies provides protection in rhesus macaques. PNAS 109:18030–18035. https://doi.org/10.
1073/pnas.1213709109
Oliphant T, Engle M, Nybakken GE, Doane C, Johnson S, Huang L, Gorlatov S, Mehlhop E,
Marri A, Chung KM, Ebel GD, Kramer LD, Fremont DH, Diamond MS (2005) Development of
a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med
11:522–530. https://doi.org/10.1038/nm1240
Paul M, Reljic R, Klein K, Drake PM, van Dolleweerd C, Pabst M, Windwarder M, Arcalis E,
Stoger E, Altmann F, Cosgrove C, Bartolf A, Baden S, Ma JK (2014) Characterization of a
plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV.
mAbs 6:1585–1597. https://doi.org/10.4161/mabs.36336
Pellegrino E, Bedini S, Nuti M, Ercoli L (2018) Impact of genetically engineered maize on
agronomic, environmental and toxicological traits: a meta-analysis of 21 years of field data.
Sci Rep 8(1):3113–3124. https://doi.org/10.1038/s41598-018-21284-2
Peréz Aguirreburualde MS, Gómez MC, Ostachuk A, Wolman F, Albanesi G, Pecora A, Odeon A,
Ardila F, Escribano JM, Dus Santos MJ, Wigdorovitz A (2013) Efficacy of a BVDV subunit
vaccine produced in alfalfa transgenic plants. Vet Immunol Immunopathol 151(3–4):315–324.
https://doi.org/10.1016/j.vetimm.2012.12.004
Pérez Filgueira D, Zamorano P, Domínguez M, Taboga O, Del Médico ZM, Puntel M, Romera SA,
Morris TJ, Borca MV, Sadir AM (2003) Bovine herpes virus gD protein produced in plants
using a recombinant tobacco mosaic virus (TMV) vector possesses authentic antigenicity.
Vaccine 21:4201–4209
Peyret H, Lomonossoff GP (2015) When plant virology met Agrobacterium: the rise of the
deconstructed clones. Plant Biotechnol J 13(8):1121–1135. https://doi.org/10.1111/pbi.12412
Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS (2011) Expression
of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol J
9(7):807–816. https://doi.org/10.1111/j.1467-7652.2011.00593.x
Pillet S, Aubin É, Trépanier S, Bussière D, Dargis M, Poulin JF, Yassine-Diab B, Ward BJ,
Landry N (2016) A plant-derived quadrivalent virus like particle influenza vaccine induces
cross-reactive antibody and T cell response in healthy adults. Clin Immunol 168:72–87. https://
doi.org/10.1016/j.clim.2016.03.008
Plosker GL, Figgitt DP (2003) Rituximab: a review of its use in non-Hodgkin’s lymphoma and
chronic lymphocytic leukaemia. Drugs 63:803–843
Pua TL, Chan XY, Loh HS, Omar AR, Yusibov V, Musiychuk K, Hall AC, Coffin MV, Shoji Y,
Chichester JA, Bi H, Streatfield SJ (2017) Purification and immunogenicity of hemagglutinin
from highly pathogenic avian influenza virus H5N1 expressed in Nicotiana benthamiana. Hum
Vaccin Immunother 13:306–313. https://doi.org/10.1080/21645515.2017.1264783
Pujol M, Gavilondo J, Ayala M, Rodríguez M, González EM, Pérez L (2007) Fighting cancer with
plant-expressed pharmaceuticals. Trends Biotechnol 25(10):455–459. https://doi.org/10.1016/j.
tibtech.2007.09.001
Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti JB, Fausther-Bovendo H, Wei H, Aviles J,
Hiatt E, Johnson A, Morton J, Swope K, Bohorov O, Bohorova N, Goodman C, Kim D,
Pauly MH, Velasco J, Pettitt J, Olinger GG, Whaley K, Xu B, Strong JE, Zeitlin L,
Kobinger GP (2014) Reversion of advanced Ebola virus disease in nonhuman primates with
ZMapp. Nature 514:47–53. https://doi.org/10.1038/nature13777
Rademacher T (2013) Method for the generation and cultivation of a plant cell pack. Patent WO
2013113504
Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N,
Anderson DR (1994) Depletion of B cells in vivo by a chimeric mouse human monoclonal
antibody to CD20. Blood 83(2):435–445
104
S. Massa et al.
Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L,
Zeitlin L (2012) Delayed treatment of Ebola virus infection with plant-derived monoclonal
antibodies provides protection in rhesus macaques. PNAS 109:18030–18035. https://doi.org/10.
1073/pnas.1213709109
Oliphant T, Engle M, Nybakken GE, Doane C, Johnson S, Huang L, Gorlatov S, Mehlhop E,
Marri A, Chung KM, Ebel GD, Kramer LD, Fremont DH, Diamond MS (2005) Development of
a humanized monoclonal antibody with therapeutic potential against West Nile virus. Nat Med
11:522–530. https://doi.org/10.1038/nm1240
Paul M, Reljic R, Klein K, Drake PM, van Dolleweerd C, Pabst M, Windwarder M, Arcalis E,
Stoger E, Altmann F, Cosgrove C, Bartolf A, Baden S, Ma JK (2014) Characterization of a
plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV.
mAbs 6:1585–1597. https://doi.org/10.4161/mabs.36336
Pellegrino E, Bedini S, Nuti M, Ercoli L (2018) Impact of genetically engineered maize on
agronomic, environmental and toxicological traits: a meta-analysis of 21 years of field data.
Sci Rep 8(1):3113–3124. https://doi.org/10.1038/s41598-018-21284-2
Peréz Aguirreburualde MS, Gómez MC, Ostachuk A, Wolman F, Albanesi G, Pecora A, Odeon A,
Ardila F, Escribano JM, Dus Santos MJ, Wigdorovitz A (2013) Efficacy of a BVDV subunit
vaccine produced in alfalfa transgenic plants. Vet Immunol Immunopathol 151(3–4):315–324.
https://doi.org/10.1016/j.vetimm.2012.12.004
Pérez Filgueira D, Zamorano P, Domínguez M, Taboga O, Del Médico ZM, Puntel M, Romera SA,
Morris TJ, Borca MV, Sadir AM (2003) Bovine herpes virus gD protein produced in plants
using a recombinant tobacco mosaic virus (TMV) vector possesses authentic antigenicity.
Vaccine 21:4201–4209
Peyret H, Lomonossoff GP (2015) When plant virology met Agrobacterium: the rise of the
deconstructed clones. Plant Biotechnol J 13(8):1121–1135. https://doi.org/10.1111/pbi.12412
Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS (2011) Expression
of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol J
9(7):807–816. https://doi.org/10.1111/j.1467-7652.2011.00593.x
Pillet S, Aubin É, Trépanier S, Bussière D, Dargis M, Poulin JF, Yassine-Diab B, Ward BJ,
Landry N (2016) A plant-derived quadrivalent virus like particle influenza vaccine induces
cross-reactive antibody and T cell response in healthy adults. Clin Immunol 168:72–87. https://
doi.org/10.1016/j.clim.2016.03.008
Plosker GL, Figgitt DP (2003) Rituximab: a review of its use in non-Hodgkin’s lymphoma and
chronic lymphocytic leukaemia. Drugs 63:803–843
Pua TL, Chan XY, Loh HS, Omar AR, Yusibov V, Musiychuk K, Hall AC, Coffin MV, Shoji Y,
Chichester JA, Bi H, Streatfield SJ (2017) Purification and immunogenicity of hemagglutinin
from highly pathogenic avian influenza virus H5N1 expressed in Nicotiana benthamiana. Hum
Vaccin Immunother 13:306–313. https://doi.org/10.1080/21645515.2017.1264783
Pujol M, Gavilondo J, Ayala M, Rodríguez M, González EM, Pérez L (2007) Fighting cancer with
plant-expressed pharmaceuticals. Trends Biotechnol 25(10):455–459. https://doi.org/10.1016/j.
tibtech.2007.09.001
Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti JB, Fausther-Bovendo H, Wei H, Aviles J,
Hiatt E, Johnson A, Morton J, Swope K, Bohorov O, Bohorova N, Goodman C, Kim D,
Pauly MH, Velasco J, Pettitt J, Olinger GG, Whaley K, Xu B, Strong JE, Zeitlin L,
Kobinger GP (2014) Reversion of advanced Ebola virus disease in nonhuman primates with
ZMapp. Nature 514:47–53. https://doi.org/10.1038/nature13777
Rademacher T (2013) Method for the generation and cultivation of a plant cell pack. Patent WO
2013113504
Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N,
Anderson DR (1994) Depletion of B cells in vivo by a chimeric mouse human monoclonal
antibody to CD20. Blood 83(2):435–445
104
S. Massa et al.