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7(1):9–14. https://doi.org/10.4161/19420862.2015.989042
European Medicines Agency (EMA) (2008) Guideline on the quality of biological active substances produced by stable transgene expression in higher plants (EMEA/CHMP/BWP/48316/
2006). European Medicines Agency, London
Fox JL (2012) First plant-made biologic approved. Nat Biotechnol 30:472 https://www.nature.com/
articles/nbt0612-472
Franconi R, Demurtas OC, Massa S (2010) Plant-derived vaccines and other therapeutics produced
in contained systems. Expert Rev Vaccines 9(8):877–892. https://doi.org/10.1586/erv.10.91
Gasdaska JR, Sherwood S, Regan JT, Dickey LF (2012) An afucosylated anti-CD20 monoclonal
antibody with greater antibody-dependent cellular cytotoxicity and B-cell depletion and lower
complement dependent cytotoxicity than rituximab. Mol Immunol 50:134–141. https://doi.org/
10.1016/j.molimm.2012.01.001
Gaughan CL (2016) The present state of the art in expression, production and characterization of
monoclonal antibodies. Mol Divers 20(1):255–270. https://doi.org/10.1007/s11030-015-9625-z
Giritch A, Marillonnet S, Engler C, van Eldik G, Botterman J, Klimyuk V, Gleba Y (2006)
Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting
viral vectors. PNAS 103(40):14701–14706. https://doi.org/10.1073/pnas.0606631103
Gleba Y, Klimyuk V, Marillonnet S (2005) Magnifection: a new platform for expressing
recombinant vaccines in plants. Vaccine 23:2042–2048. https://doi.org/10.1016/j.vaccine.
2005.01.006
Goodin MM, Zaitlin D, Naidu RA, Lommel SA (2008) Nicotiana benthamiana: its history and
future as a model for plant-pathogen interactions. Mol Plant Microbe Interact 21(8):1015–1026.
https://doi.org/10.1094/MPMI-21-8-1015
Gorantala J, Grover S, Rahi A, Chaudhary P, Rajwanshi R, Sarin NB, Bhatnagar R (2014)
Generation of protective immune response against anthrax by oral immunization with protective
antigen plant-based vaccine. J Biotechnol 176:1–10. https://doi.org/10.1016/j.jbiotec.2014.01.
033
Govea-Alonso DO, Rubio-Infante N, García-Hernández AL, Varona-Santos JT, Korban SS,
Moreno-Fierros L, Rosales-Mendoza S (2013) Immunogenic properties of a lettuce-derived
C4(V3)6 multiepitopic HIV protein. Planta 238(4):785–792. https://doi.org/10.1007/s00425013-1932-y
Grohs BM, Niu Y, Veldhuis LJ, Trabelsi S, Garabagi F, Hassell JA, McLean MD, Hall JC (2010)
Plant-produced trastuzumab inhibits the growth of HER2 positive cancer cells. J Agric Food
Chem 58(18):10056–10063. https://doi.org/10.1021/jf102284f
Guerrero-Andrade O, Loza-Rubio E, Olivera-Flores T, Fehérvári-Bone T, Gómez-Lim M (2006)
Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological
studies. Transgenic Res 15:455–463. https://doi.org/10.1007/s11248-006-0017-0
Guillon S, Trémouillaux-Guiller J, Pati PK, Rideau M, Gantet P (2006) Hairy root research: recent
scenario and exciting prospects. Curr Opin Plant Biol 9(3):341–346. https://doi.org/10.1016/j.
pbi.2006.03.008
Haq TA, Mason HS, Clements JD, Arntzen CJ (1995) Oral immunization with a recombinant
bacterial antigen produced in transgenic plants. Science 268(5211):714–716
Havenith H, Raven N, Di Fiore S, Fischer R, Schillberg S (2014) Image-based analysis of
cell-specific productivity for plant cell suspension cultures. Plant Cell Tissue Organ Cult
117:393–399. https://doi.org/10.1007/s11240-014-0448-x
He J, Lai H, Engle M, Gorlatov S, Gruber C, Steinkellner H, Diamond MS, Chen Q (2014)
Generation and analysis of novel plant-derived antibody-based therapeutic molecules against
West Nile virus. PLoS One 9:e93541. https://doi.org/10.1371/journal.pone.0093541
Hellwig S, Drossard J, Twyman RM, Fischer R (2004) Plant cell cultures for the production of
recombinant proteins. Nat Biotechnol 22(11):1415–1422. https://doi.org/10.1038/nbt1027
Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN, Koff WC, Watkins DI,
Burton DR (2009) Broadly neutralizing human anti-HIV antibody 2G12 is effective in
100
S. Massa et al.
7(1):9–14. https://doi.org/10.4161/19420862.2015.989042
European Medicines Agency (EMA) (2008) Guideline on the quality of biological active substances produced by stable transgene expression in higher plants (EMEA/CHMP/BWP/48316/
2006). European Medicines Agency, London
Fox JL (2012) First plant-made biologic approved. Nat Biotechnol 30:472 https://www.nature.com/
articles/nbt0612-472
Franconi R, Demurtas OC, Massa S (2010) Plant-derived vaccines and other therapeutics produced
in contained systems. Expert Rev Vaccines 9(8):877–892. https://doi.org/10.1586/erv.10.91
Gasdaska JR, Sherwood S, Regan JT, Dickey LF (2012) An afucosylated anti-CD20 monoclonal
antibody with greater antibody-dependent cellular cytotoxicity and B-cell depletion and lower
complement dependent cytotoxicity than rituximab. Mol Immunol 50:134–141. https://doi.org/
10.1016/j.molimm.2012.01.001
Gaughan CL (2016) The present state of the art in expression, production and characterization of
monoclonal antibodies. Mol Divers 20(1):255–270. https://doi.org/10.1007/s11030-015-9625-z
Giritch A, Marillonnet S, Engler C, van Eldik G, Botterman J, Klimyuk V, Gleba Y (2006)
Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting
viral vectors. PNAS 103(40):14701–14706. https://doi.org/10.1073/pnas.0606631103
Gleba Y, Klimyuk V, Marillonnet S (2005) Magnifection: a new platform for expressing
recombinant vaccines in plants. Vaccine 23:2042–2048. https://doi.org/10.1016/j.vaccine.
2005.01.006
Goodin MM, Zaitlin D, Naidu RA, Lommel SA (2008) Nicotiana benthamiana: its history and
future as a model for plant-pathogen interactions. Mol Plant Microbe Interact 21(8):1015–1026.
https://doi.org/10.1094/MPMI-21-8-1015
Gorantala J, Grover S, Rahi A, Chaudhary P, Rajwanshi R, Sarin NB, Bhatnagar R (2014)
Generation of protective immune response against anthrax by oral immunization with protective
antigen plant-based vaccine. J Biotechnol 176:1–10. https://doi.org/10.1016/j.jbiotec.2014.01.
033
Govea-Alonso DO, Rubio-Infante N, García-Hernández AL, Varona-Santos JT, Korban SS,
Moreno-Fierros L, Rosales-Mendoza S (2013) Immunogenic properties of a lettuce-derived
C4(V3)6 multiepitopic HIV protein. Planta 238(4):785–792. https://doi.org/10.1007/s00425013-1932-y
Grohs BM, Niu Y, Veldhuis LJ, Trabelsi S, Garabagi F, Hassell JA, McLean MD, Hall JC (2010)
Plant-produced trastuzumab inhibits the growth of HER2 positive cancer cells. J Agric Food
Chem 58(18):10056–10063. https://doi.org/10.1021/jf102284f
Guerrero-Andrade O, Loza-Rubio E, Olivera-Flores T, Fehérvári-Bone T, Gómez-Lim M (2006)
Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological
studies. Transgenic Res 15:455–463. https://doi.org/10.1007/s11248-006-0017-0
Guillon S, Trémouillaux-Guiller J, Pati PK, Rideau M, Gantet P (2006) Hairy root research: recent
scenario and exciting prospects. Curr Opin Plant Biol 9(3):341–346. https://doi.org/10.1016/j.
pbi.2006.03.008
Haq TA, Mason HS, Clements JD, Arntzen CJ (1995) Oral immunization with a recombinant
bacterial antigen produced in transgenic plants. Science 268(5211):714–716
Havenith H, Raven N, Di Fiore S, Fischer R, Schillberg S (2014) Image-based analysis of
cell-specific productivity for plant cell suspension cultures. Plant Cell Tissue Organ Cult
117:393–399. https://doi.org/10.1007/s11240-014-0448-x
He J, Lai H, Engle M, Gorlatov S, Gruber C, Steinkellner H, Diamond MS, Chen Q (2014)
Generation and analysis of novel plant-derived antibody-based therapeutic molecules against
West Nile virus. PLoS One 9:e93541. https://doi.org/10.1371/journal.pone.0093541
Hellwig S, Drossard J, Twyman RM, Fischer R (2004) Plant cell cultures for the production of
recombinant proteins. Nat Biotechnol 22(11):1415–1422. https://doi.org/10.1038/nbt1027
Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN, Koff WC, Watkins DI,
Burton DR (2009) Broadly neutralizing human anti-HIV antibody 2G12 is effective in
100
S. Massa et al.