Chichester JA, Manceva SD, Rhee A, Coffin MV, Musiychuk K, Mett V, Shamloul M, Norikane J,
Streatfield SJ, Yusibov V (2013) A plant-produced protective antigen vaccine confers protection
in rabbits against a lethal aerosolized challenge with Bacillus anthracis Ames spores. Hum
Vaccin Immunother 9(3):544–552
Cho SW, Lee J, Carroll D, Kim JS, Lee J (2013) Heritable gene knockout in Caenorhabditis elegans
by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics 195(3):1177–1180. https://doi.
org/10.1534/genetics.113.155853
Clarke JL, Waheed MT, Lössl AG, Martinussen I, Daniell H (2013) How can plant genetic
engineering contribute to cost-effective fish vaccine development for promoting sustainable
aquaculture? Plant Mol Biol 83(1–2):33–40. https://doi.org/10.1007/s11103-013-0081-9
Cox KM, Sterling JD, Regan JT, Gasdaska JR, Frantz KK, Peele CG, Black A, Passmore D,
Moldovan-Loomis C, Srinivasan M, Cuison S, Cardarelli PM, Dickey LF (2006) Glycan
optimization of a human monoclonal antibody in the aquatic plant Lemna minor. Nat Biotechnol
24:1591–1597. https://doi.org/10.1038/nbt1260
Czyż M, Dembczyński R, Marecik R, Wojas-Turek J, Milczarek M, Pajtasz-Piasecka E, Wietrzyk J,
Pniewski T (2014) Freeze-drying of plant tissue containing HBV surface antigen for the oral
vaccine against hepatitis B. Biomed Res Int 2014:485689. https://doi.org/10.1155/2014/485689
Dafny-Yelin M, Tzfira T (2007) Delivery of multiple transgenes to plant cells. Plant Physiol
145(4):1118–1128
Daniell H (2003) Medical molecular pharming: expression of antibodies, biopharmaceuticals and
edible vaccines via the chloroplast genome. In: Plant biotechnology and beyond 2002. Springer,
Dordrecht, pp 371–376. https://doi.org/10.1007/978-94-017-2679-5_76
D'Aoust MA, Couture MM, Charland N, Trépanier S, Landry N, Ors F, Vézina LP (2010)
The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and
safe response to pandemic influenza. Plant Biotechnol J 8(5):607–619. https://doi.org/10.
1111/j.1467-7652.2009.00496.x
Davey RT Jr, Dodd L, Proschan MA, Neaton J, Nordwall JN, Koopmeiners JS, Beigel J, Tierney J,
Lane HC, Fauci AS, Massaquoi MBF, Sahr F, Malvy D (2016) A randomized, controlled trial of
ZMapp for Ebola virus infection. N Engl J Med 375:1448–1456. https://doi.org/10.1056/
NEJMoa1604330
Davies HM (2010) Commercialization of whole-plant systems for biomanufacturing of protein
products: evolution and prospects. Plant Biotechnol J 8(8):845–861. https://doi.org/10.1111/j.
1467-7652.2010.00550.x
Davis BTA, Grillo-Lopez AJ, White CA, Mclaughlin P, Czuczman MS, Link BK, Maloney DG,
Weaver RL, Rosenberg J, Levy R (2014) Rituximab anti-CD20 monoclonal antibody therapy in
non-Hodgkin’s lymphoma: safety and efficacy of re-treatment. J Clin Oncol 18:3135–3143.
https://doi.org/10.1200/JCO.2000.18.17.3135
De Muynck B, Navarre C, Boutry M (2010) Production of antibodies in plants: status after twenty
years. Plant Biotechnol J 8:529–563. https://doi.org/10.1111/j.1467-7652.2009.00494.x
Demurtas OC, Massa S, Ferrante P, Venuti A, Franconi R, Giuliano G (2013) A Chlamydomonasderived human papillomavirus 16 E7 vaccine induces specific tumor protection. PLoS One 8(4):
e61473. https://doi.org/10.1371/journal.pone.0061473
Demurtas OC, Massa S, Illiano E, De Martinis D, Chan PK, Di Bonito P, Franconi R (2016)
Antigen production in plant to tackle infectious diseases flare up: the case of SARS. Front Plant
Sci 7:54–66. https://doi.org/10.3389/fpls.2016.00054
Drake PM, de Moraes ML, Szeto TH, Ma JK (2013) Transformation of Althaea officinalis
L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the antiHIV microbicide cyanovirin-N. Transgenic Res 22(6):1225–1229. https://doi.org/10.1007/
s11248-013-9730-7
Drake PM, Szeto TH, Paul MJ, Teh AY, Ma JK (2017) Recombinant biologic products versus
nutraceuticals from plants - a regulatory choice? Br J Clin Pharmacol 83(1):82–87. https://doi.
org/10.1111/bcp.13041
Engineering Plants for the Future: Farming with Value-Added Harvest
99
Streatfield SJ, Yusibov V (2013) A plant-produced protective antigen vaccine confers protection
in rabbits against a lethal aerosolized challenge with Bacillus anthracis Ames spores. Hum
Vaccin Immunother 9(3):544–552
Cho SW, Lee J, Carroll D, Kim JS, Lee J (2013) Heritable gene knockout in Caenorhabditis elegans
by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics 195(3):1177–1180. https://doi.
org/10.1534/genetics.113.155853
Clarke JL, Waheed MT, Lössl AG, Martinussen I, Daniell H (2013) How can plant genetic
engineering contribute to cost-effective fish vaccine development for promoting sustainable
aquaculture? Plant Mol Biol 83(1–2):33–40. https://doi.org/10.1007/s11103-013-0081-9
Cox KM, Sterling JD, Regan JT, Gasdaska JR, Frantz KK, Peele CG, Black A, Passmore D,
Moldovan-Loomis C, Srinivasan M, Cuison S, Cardarelli PM, Dickey LF (2006) Glycan
optimization of a human monoclonal antibody in the aquatic plant Lemna minor. Nat Biotechnol
24:1591–1597. https://doi.org/10.1038/nbt1260
Czyż M, Dembczyński R, Marecik R, Wojas-Turek J, Milczarek M, Pajtasz-Piasecka E, Wietrzyk J,
Pniewski T (2014) Freeze-drying of plant tissue containing HBV surface antigen for the oral
vaccine against hepatitis B. Biomed Res Int 2014:485689. https://doi.org/10.1155/2014/485689
Dafny-Yelin M, Tzfira T (2007) Delivery of multiple transgenes to plant cells. Plant Physiol
145(4):1118–1128
Daniell H (2003) Medical molecular pharming: expression of antibodies, biopharmaceuticals and
edible vaccines via the chloroplast genome. In: Plant biotechnology and beyond 2002. Springer,
Dordrecht, pp 371–376. https://doi.org/10.1007/978-94-017-2679-5_76
D'Aoust MA, Couture MM, Charland N, Trépanier S, Landry N, Ors F, Vézina LP (2010)
The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and
safe response to pandemic influenza. Plant Biotechnol J 8(5):607–619. https://doi.org/10.
1111/j.1467-7652.2009.00496.x
Davey RT Jr, Dodd L, Proschan MA, Neaton J, Nordwall JN, Koopmeiners JS, Beigel J, Tierney J,
Lane HC, Fauci AS, Massaquoi MBF, Sahr F, Malvy D (2016) A randomized, controlled trial of
ZMapp for Ebola virus infection. N Engl J Med 375:1448–1456. https://doi.org/10.1056/
NEJMoa1604330
Davies HM (2010) Commercialization of whole-plant systems for biomanufacturing of protein
products: evolution and prospects. Plant Biotechnol J 8(8):845–861. https://doi.org/10.1111/j.
1467-7652.2010.00550.x
Davis BTA, Grillo-Lopez AJ, White CA, Mclaughlin P, Czuczman MS, Link BK, Maloney DG,
Weaver RL, Rosenberg J, Levy R (2014) Rituximab anti-CD20 monoclonal antibody therapy in
non-Hodgkin’s lymphoma: safety and efficacy of re-treatment. J Clin Oncol 18:3135–3143.
https://doi.org/10.1200/JCO.2000.18.17.3135
De Muynck B, Navarre C, Boutry M (2010) Production of antibodies in plants: status after twenty
years. Plant Biotechnol J 8:529–563. https://doi.org/10.1111/j.1467-7652.2009.00494.x
Demurtas OC, Massa S, Ferrante P, Venuti A, Franconi R, Giuliano G (2013) A Chlamydomonasderived human papillomavirus 16 E7 vaccine induces specific tumor protection. PLoS One 8(4):
e61473. https://doi.org/10.1371/journal.pone.0061473
Demurtas OC, Massa S, Illiano E, De Martinis D, Chan PK, Di Bonito P, Franconi R (2016)
Antigen production in plant to tackle infectious diseases flare up: the case of SARS. Front Plant
Sci 7:54–66. https://doi.org/10.3389/fpls.2016.00054
Drake PM, de Moraes ML, Szeto TH, Ma JK (2013) Transformation of Althaea officinalis
L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the antiHIV microbicide cyanovirin-N. Transgenic Res 22(6):1225–1229. https://doi.org/10.1007/
s11248-013-9730-7
Drake PM, Szeto TH, Paul MJ, Teh AY, Ma JK (2017) Recombinant biologic products versus
nutraceuticals from plants - a regulatory choice? Br J Clin Pharmacol 83(1):82–87. https://doi.
org/10.1111/bcp.13041
Engineering Plants for the Future: Farming with Value-Added Harvest
99