protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog
5:e1000433. https://doi.org/10.1371/journal.ppat.1000433
Hiatt A, Cafferkey R, Bowdish K (1989) Production of antibodies in transgenic plants. Nature
342(6245):76–78. https://doi.org/10.1038/342076a0
Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ,
Piedra PA, Gilbert BE, Zeitlin L (2014) Glycan variants of a respiratory syncytial virus antibody
with enhanced effector function and in vivo efficacy. PNAS 111:5992–5997. https://doi.org/10.
1073/pnas.1402458111
Hongli L, Xukui L, Ting L, Wensheng L, Lusheng S, Jin Z (2013) Transgenic tobacco expressed
HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune
responses in mice. Hum Vaccin Immunother 9:83–89. https://doi.org/10.4161/hv.22292
Huang Z, Santi L, LePore K, Kilbourne J, Arntzen CJ, Mason HS (2006) Rapid, high-level
production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine
24(14):2506–2513. https://doi.org/10.1016/j.vaccine.2005.12.024
Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ,
Mason HS, Chen Q (2010) High-level rapid production of full-size monoclonal antibodies in
plants by a single-vector DNA replicon system. Biotechnol Bioeng 106(1):9–17. https://doi.org/
10.1002/bit.22652
Joensuu JJ, Verdonck F, Ehrström A, Peltola M, Siljander-Rasi H, Nuutila AM, Oksman-Caldentey
KM, Teeri TH, Cox E, Goddeeris BM, Niklander-Teeri V (2006) F4 (K88) fimbrial adhesin
FaeG expressed in alfalfa reduces F4+ enterotoxigenic Escherichia coli excretion in weaned
piglets. Vaccine 24(13):2387–2394. https://doi.org/10.1016/j.vaccine.2005.11.056
Kapusta J, Modelska A, Figlerowicz M, Pniewski T, Letellier M, Lisowa O, Yusibov V,
Koprowski H, Plucienniczak A, Legocki AB (1999) A plant-derived edible vaccine against
hepatitis B virus. FASEB J 13(13):1796–1799 Erratum in: FASEB J 1999 13(15):2339
Katsnelson A, Ransom J, Vermij P, Waltz E (2006) News in brief: USDA approves the first plantbased vaccine. Nat Biotechnol 24(3):233–234 http://www.nature.com/articles/nbt0306-233#t1
Kessans SA, Linhart MD, Meador LR, Kilbourne J, Hogue BG, Fromme P, Matoba N, Mor TS
(2016) Immunological characterization of plant-based HIV-1 Gag/Dgp41 virus-like particles.
PLoS One 11(3):e0151842. https://doi.org/10.1371/journal.pone.0151842
Khandelwal A, Lakshmi Sita G, Shaila MS (2003) Oral immunization of cattle with hemagglutinin
protein of rinderpest virus expressed in transgenic peanut induces specific immune responses.
Vaccine 21(23):3282–3289
Kim S, Kim D, Cho SW, Kim J, Kim JS (2014) Highly efficient RNA-guided genome editing in
human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res 24(6):1012–1019.
https://doi.org/10.1101/gr.171322.113
Kim MY, Reljic R, Kilbourne J, Ceballos-Olvera I, Yang MS, Reyes-Del Valle J, Mason HS (2015)
Novel vaccination approach for dengue infection based on recombinant immune complex
universal platform. Vaccine 33:1830–1880. https://doi.org/10.1016/j.vaccine.2015.02.036
Klein C, Lammens A, Schäfer W, Georges G, Schwaiger M, Mössner E, Hopfner KP, Umaña P,
Niederfellner G (2013) MAbs 5(1):22–33. https://doi.org/10.4161/mabs.22771
Ko K, Steplewski Z, Glogowska M, Koprowski H (2005) Inhibition of tumor growth by
plant-derived mAb. Proc Natl Acad Sci U S A 102(19):7026–7030. https://doi.org/10.1073/
pnas.0502533102
Kolotilin I, Kaldis A, Devriendt B, Joensuu J, Cox E, Menassa R (2012) Production of a subunit
vaccine candidate against porcine postweaning diarrhea in high-biomass transplastomic
tobacco. PLoS One 7:e42405. https://doi.org/10.1371/journal.pone.0042405
Komarova TV, Baschieri S, Donini M, Marusic C, Benvenuto E, Dorokhov YL (2010) Transient
expression systems for plant-derived biopharmaceuticals. Expert Rev Vaccines 9(8):859–876.
https://doi.org/10.1586/erv.10.85
Komarova TV, Kosorukov VS, Frolova OY, Petrunia IV, Skrypnik KA, Gleba YY, Dorokhov YL
(2011) Plant-made trastuzumab (herceptin) inhibits HER2/Neu+ cell proliferation and retards
tumor growth. PLoS One 6(3):e17541. https://doi.org/10.1371/journal.pone.0017541
Engineering Plants for the Future: Farming with Value-Added Harvest
101
5:e1000433. https://doi.org/10.1371/journal.ppat.1000433
Hiatt A, Cafferkey R, Bowdish K (1989) Production of antibodies in transgenic plants. Nature
342(6245):76–78. https://doi.org/10.1038/342076a0
Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ,
Piedra PA, Gilbert BE, Zeitlin L (2014) Glycan variants of a respiratory syncytial virus antibody
with enhanced effector function and in vivo efficacy. PNAS 111:5992–5997. https://doi.org/10.
1073/pnas.1402458111
Hongli L, Xukui L, Ting L, Wensheng L, Lusheng S, Jin Z (2013) Transgenic tobacco expressed
HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune
responses in mice. Hum Vaccin Immunother 9:83–89. https://doi.org/10.4161/hv.22292
Huang Z, Santi L, LePore K, Kilbourne J, Arntzen CJ, Mason HS (2006) Rapid, high-level
production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine
24(14):2506–2513. https://doi.org/10.1016/j.vaccine.2005.12.024
Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ,
Mason HS, Chen Q (2010) High-level rapid production of full-size monoclonal antibodies in
plants by a single-vector DNA replicon system. Biotechnol Bioeng 106(1):9–17. https://doi.org/
10.1002/bit.22652
Joensuu JJ, Verdonck F, Ehrström A, Peltola M, Siljander-Rasi H, Nuutila AM, Oksman-Caldentey
KM, Teeri TH, Cox E, Goddeeris BM, Niklander-Teeri V (2006) F4 (K88) fimbrial adhesin
FaeG expressed in alfalfa reduces F4+ enterotoxigenic Escherichia coli excretion in weaned
piglets. Vaccine 24(13):2387–2394. https://doi.org/10.1016/j.vaccine.2005.11.056
Kapusta J, Modelska A, Figlerowicz M, Pniewski T, Letellier M, Lisowa O, Yusibov V,
Koprowski H, Plucienniczak A, Legocki AB (1999) A plant-derived edible vaccine against
hepatitis B virus. FASEB J 13(13):1796–1799 Erratum in: FASEB J 1999 13(15):2339
Katsnelson A, Ransom J, Vermij P, Waltz E (2006) News in brief: USDA approves the first plantbased vaccine. Nat Biotechnol 24(3):233–234 http://www.nature.com/articles/nbt0306-233#t1
Kessans SA, Linhart MD, Meador LR, Kilbourne J, Hogue BG, Fromme P, Matoba N, Mor TS
(2016) Immunological characterization of plant-based HIV-1 Gag/Dgp41 virus-like particles.
PLoS One 11(3):e0151842. https://doi.org/10.1371/journal.pone.0151842
Khandelwal A, Lakshmi Sita G, Shaila MS (2003) Oral immunization of cattle with hemagglutinin
protein of rinderpest virus expressed in transgenic peanut induces specific immune responses.
Vaccine 21(23):3282–3289
Kim S, Kim D, Cho SW, Kim J, Kim JS (2014) Highly efficient RNA-guided genome editing in
human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res 24(6):1012–1019.
https://doi.org/10.1101/gr.171322.113
Kim MY, Reljic R, Kilbourne J, Ceballos-Olvera I, Yang MS, Reyes-Del Valle J, Mason HS (2015)
Novel vaccination approach for dengue infection based on recombinant immune complex
universal platform. Vaccine 33:1830–1880. https://doi.org/10.1016/j.vaccine.2015.02.036
Klein C, Lammens A, Schäfer W, Georges G, Schwaiger M, Mössner E, Hopfner KP, Umaña P,
Niederfellner G (2013) MAbs 5(1):22–33. https://doi.org/10.4161/mabs.22771
Ko K, Steplewski Z, Glogowska M, Koprowski H (2005) Inhibition of tumor growth by
plant-derived mAb. Proc Natl Acad Sci U S A 102(19):7026–7030. https://doi.org/10.1073/
pnas.0502533102
Kolotilin I, Kaldis A, Devriendt B, Joensuu J, Cox E, Menassa R (2012) Production of a subunit
vaccine candidate against porcine postweaning diarrhea in high-biomass transplastomic
tobacco. PLoS One 7:e42405. https://doi.org/10.1371/journal.pone.0042405
Komarova TV, Baschieri S, Donini M, Marusic C, Benvenuto E, Dorokhov YL (2010) Transient
expression systems for plant-derived biopharmaceuticals. Expert Rev Vaccines 9(8):859–876.
https://doi.org/10.1586/erv.10.85
Komarova TV, Kosorukov VS, Frolova OY, Petrunia IV, Skrypnik KA, Gleba YY, Dorokhov YL
(2011) Plant-made trastuzumab (herceptin) inhibits HER2/Neu+ cell proliferation and retards
tumor growth. PLoS One 6(3):e17541. https://doi.org/10.1371/journal.pone.0017541
Engineering Plants for the Future: Farming with Value-Added Harvest
101