in the Data Set with degree 12. This global distribution means that
the degrees are driven by a normal distribution to have a majority of
moderate degrees and not too many high or low degrees. While
each node could control the 2D, 3D, and/or 4D structures of the
protein, the normal distribution of degrees masks the role of each
node (that is, we are not able to predict the structural role of each
amino just by looking at its degree).
5.2 Degree
Distribution in Hot
Spot Network
The Hot Spot Network is constructed by adjacent amino acids in
two different chains and compose the interfaces of the protein. We
remark that this network between two chains is bipartite: that is
between two chains the first neighbors of a given Hot Spot are Hot
Spots of the other chain (Fig. 14). Indeed, two nodes of a link in
this network fall by construction in two distinct chains. We first
Fig. 12 Degree distribution of PCN for the Cholera Toxin
Fig. 13 Degree distribution of PCN on the whole Data Set
Topology Results on Adjacent Amino Acid Networks of Oligomeric Proteins
125