30
Ji C, Miller PA, Miller MJ (2012) Iron transport-mediated drug delivery: practical syntheses and
in vitro antibacterial studies of tris-catecholate siderophore–aminopenicillin conjugates reveals
selectively potent antipseudomonal activity. J Am Chem Soc 134:9898–9901
Kanoh K, Kamino K (2001) Effect of exogenous siderophores on iron uptake activity of marine
bacteria under iron-limited conditions. Appl Environ Microbiol 67:1710–1717
Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism—from biochemistry to
genomics. Nat Rev Microbiol 3:937–947
Leal SM Jr, Roy S, Vareechon C et al (2013) Targeting iron acquisition blocks infection with the
fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog 9:e1003436
Lee TV, Johnson LJ, Johnson RD et al (2010a) Structure of a eukaryotic nonribosomal peptide
synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore
biosynthesis. J Biol Chem 285:2415–2427
Lee TV, Lott JS, Johnson RD et al (2010b) Expression and purification of an adenylation domain
from a eukaryotic nonribosomal peptide synthetase: using structural genomics tools for a challenging target. Protein Expr Purif 74:162–168
Macreadie IG, Johnson G, Schlosser T et al (2006) Growth inhibition of Candida species and
Aspergillus fumigatus by statins. FEMS Microbiol Lett 262:9–13
Martín del Campo JS, Vogelaar N, Tolani K et al (2016) Inhibition of the flavin-dependent monooxygenase siderophore A (SidA) blocks siderophore biosynthesis and Aspergillus fumigatus
growth. ACS Chem Biol 11:3035–3042
McRose DL, Oliver B, Seyedsayamdost MR et al (2018) Quorum sensing and iron regulate a twofor- one siderophore gene cluster in Vibrio harveyi. Proc Natl Acad Sci U S A 115:7581–7586
Miethke M, Marahiel MA (2007) Siderophore-based iron acquisition and pathogen control.
Microbiol Mol Biol Rev 71:413–451
Möllmann U, Heinisch L, Bauernfeind A et al (2009) Siderophores as drug delivery agents: application of the “Trojan Horse” strategy. Biometals 22:615–624
Moore MM (2013) The crucial role of iron uptake in Aspergillus fumigatus virulence. Curr Opin
Microbiol 16:692–699
Mootz HD, Schwarzer D, Marahiel MA (2002) Ways of assembling complex natural products on
modular nonribosomal peptide synthetases. Chem Bio Chem 3:490–504
Neilands J (1995) Siderophores: structure and function of microbial iron transport compounds. J
Biol Chem 270:26723–26726
Obama B (2014) The White House Executive Order—combating antibiotic-resistant bacteria,
September, 18
Olucha J, Lamb AL (2011) Mechanistic and structural studies of the N-hydroxylating flavoprotein
monooxygenases. Bioorg Chem 39:171–177
Park BJ, Wannemuehler KA, Marston BJ et al (2009) Estimation of the current global burden of
Cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23:525–530
Pinto L, Moore M (2009) Screening method to identify inhibitors of siderophore biosynthesis in
the opportunistic fungal pathogen, Aspergillus fumigatus. Lett Appl Microbiol 49:8–13
Pramanik A, Stroeher UH, Krejci J et al (2007) Albomycin is an effective antibiotic, as exemplified
with Yersinia enterocolitica and Streptococcus pneumoniae. Int J Med Microbiol 297:459–469
Qi J, Kizjakina K, Robinson R et al (2012) A fluorescence polarization binding assay to identify
inhibitors of flavin-dependent monooxygenases. Anal Chem 425:80–87
Ravichandiran V, Shanmugam K, Anupama K et al (2012) Structure-based virtual screening for
plant-derived SdiA-selective ligands as potential antivirulent agents against uropathogenic
Escherichia coli. Eur J Med Chem 48:200–205
Raymond-Bouchard I, Carroll CS, Nesbitt JR et al (2012) Structural requirements for the activity
of the MirB ferrisiderophore transporter of Aspergillus fumigatus. Eukaryot Cell 11:1333–1344
Renshaw JC, Robson GD, Trinci APJ et al (2002) Fungal siderophores: structures, functions and
applications. Mycol Res 106:1123–1142
S. Bhatia and S. Singh
Ji C, Miller PA, Miller MJ (2012) Iron transport-mediated drug delivery: practical syntheses and
in vitro antibacterial studies of tris-catecholate siderophore–aminopenicillin conjugates reveals
selectively potent antipseudomonal activity. J Am Chem Soc 134:9898–9901
Kanoh K, Kamino K (2001) Effect of exogenous siderophores on iron uptake activity of marine
bacteria under iron-limited conditions. Appl Environ Microbiol 67:1710–1717
Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism—from biochemistry to
genomics. Nat Rev Microbiol 3:937–947
Leal SM Jr, Roy S, Vareechon C et al (2013) Targeting iron acquisition blocks infection with the
fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog 9:e1003436
Lee TV, Johnson LJ, Johnson RD et al (2010a) Structure of a eukaryotic nonribosomal peptide
synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore
biosynthesis. J Biol Chem 285:2415–2427
Lee TV, Lott JS, Johnson RD et al (2010b) Expression and purification of an adenylation domain
from a eukaryotic nonribosomal peptide synthetase: using structural genomics tools for a challenging target. Protein Expr Purif 74:162–168
Macreadie IG, Johnson G, Schlosser T et al (2006) Growth inhibition of Candida species and
Aspergillus fumigatus by statins. FEMS Microbiol Lett 262:9–13
Martín del Campo JS, Vogelaar N, Tolani K et al (2016) Inhibition of the flavin-dependent monooxygenase siderophore A (SidA) blocks siderophore biosynthesis and Aspergillus fumigatus
growth. ACS Chem Biol 11:3035–3042
McRose DL, Oliver B, Seyedsayamdost MR et al (2018) Quorum sensing and iron regulate a twofor- one siderophore gene cluster in Vibrio harveyi. Proc Natl Acad Sci U S A 115:7581–7586
Miethke M, Marahiel MA (2007) Siderophore-based iron acquisition and pathogen control.
Microbiol Mol Biol Rev 71:413–451
Möllmann U, Heinisch L, Bauernfeind A et al (2009) Siderophores as drug delivery agents: application of the “Trojan Horse” strategy. Biometals 22:615–624
Moore MM (2013) The crucial role of iron uptake in Aspergillus fumigatus virulence. Curr Opin
Microbiol 16:692–699
Mootz HD, Schwarzer D, Marahiel MA (2002) Ways of assembling complex natural products on
modular nonribosomal peptide synthetases. Chem Bio Chem 3:490–504
Neilands J (1995) Siderophores: structure and function of microbial iron transport compounds. J
Biol Chem 270:26723–26726
Obama B (2014) The White House Executive Order—combating antibiotic-resistant bacteria,
September, 18
Olucha J, Lamb AL (2011) Mechanistic and structural studies of the N-hydroxylating flavoprotein
monooxygenases. Bioorg Chem 39:171–177
Park BJ, Wannemuehler KA, Marston BJ et al (2009) Estimation of the current global burden of
Cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23:525–530
Pinto L, Moore M (2009) Screening method to identify inhibitors of siderophore biosynthesis in
the opportunistic fungal pathogen, Aspergillus fumigatus. Lett Appl Microbiol 49:8–13
Pramanik A, Stroeher UH, Krejci J et al (2007) Albomycin is an effective antibiotic, as exemplified
with Yersinia enterocolitica and Streptococcus pneumoniae. Int J Med Microbiol 297:459–469
Qi J, Kizjakina K, Robinson R et al (2012) A fluorescence polarization binding assay to identify
inhibitors of flavin-dependent monooxygenases. Anal Chem 425:80–87
Ravichandiran V, Shanmugam K, Anupama K et al (2012) Structure-based virtual screening for
plant-derived SdiA-selective ligands as potential antivirulent agents against uropathogenic
Escherichia coli. Eur J Med Chem 48:200–205
Raymond-Bouchard I, Carroll CS, Nesbitt JR et al (2012) Structural requirements for the activity
of the MirB ferrisiderophore transporter of Aspergillus fumigatus. Eukaryot Cell 11:1333–1344
Renshaw JC, Robson GD, Trinci APJ et al (2002) Fungal siderophores: structures, functions and
applications. Mycol Res 106:1123–1142
S. Bhatia and S. Singh