29
Beck-Sagué C, Dooley SW, Hutton MD et al (1992) Hospital outbreak of multidrug-resistant
Mycobacterium tuberculosis infections: factors in transmission to staff and HIV-infected
patients. JAMA 268:1280–1286
Bernier G, Girijavallabhan V, Murray A et al (2005) Desketoneoenactin-siderophore conjugates
for Candida: evidence of iron transport-dependent species selectivity. Antimicrob Agents
Chemother 49:241–248
Blatzer M, Schrettl M, Sarg B et al (2011) SidL an Aspergillus fumigatus transacetylase involved
in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl Environ Microbiol
77:4959–4966
Braun V, Pramanik A, Gwinner T et al (2009) Sideromycins: tools and antibiotics. Biometals
22:3–13
Chamilos G, Lewis RE, Kontoyiannis DP (2006) Lovastatin has significant activity against
zygomycetes and interacts synergistically with voriconazole. Antimicrob Agents Chemother
50:96–103
Chaudhary AS (2016) A review of global initiatives to fight antibiotic resistance and recent antibiotics’ discovery. Acta Pharm Sin B 6:552–556
Cisar JS, Ferreras JA, Soni RK et al (2007) Exploiting ligand conformation in selective inhibition
of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small
molecules. J Am Chem Soc 129:7752–7753
Clatworthy AE, Pierson E, Hung DT (2007) Targeting virulence: a new paradigm for antimicrobial
therapy. Nat Chem Biol 3:541–548
Cornelis P, Matthijs S (2002) Diversity of siderophore-mediated iron uptake systems in fluorescent
pseudomonads: not only pyoverdines. Environ Microbiol 4:787–798
da Silva ACR, Ferro JA, Reinach FC et al (2002) Comparison of the genomes of two Xanthomonas
pathogens with differing host specificities. Nature 417:459–463
Eisendle M, Oberegger H, Zadra I et al (2003) The siderophore system is essential for viability of
Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5- monooxygenase
(sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 49:359–375
Farkas V (1985) The fungal cell wall. In: Fungal protoplasts: applications in biochemistry genetics.
Marcel Dekker, New York/Basel, pp 3–29
Farkas E, Szabó O, Gyémánt G et al (2018) Complexation of hydroxamate-based siderophores
with cobalt (II/III): growth inhibitory effect of cobalt (III)-desferricoprogen complex on fungi.
Transit Met Chem 43:355–365
Ferreras JA, Ryu JS, Di Lello F et al (2005) Small-molecule inhibition of siderophore biosynthesis
in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol 1:29–32
Finking R, Neumüller A, Solsbacher J et al (2003) Aminoacyl adenylate substrate analogues for
the inhibition of adenylation domains of nonribosomal peptide synthetases. Chem Bio Chem
4:903–906
Galgóczy L, Nyilasi I, Papp T et al (2009) Are statins applicable for the prevention and treatment
of zygomycosis? Clin Infect Dis 49:483–484
Gootz TD (2010) The global problem of antibiotic resistance. Crit Rev Immunol 30:79–93
Górska A, Sloderbach A, Marszałł MP (2014) Siderophore–drug complexes: potential medicinal
applications of the ‘Trojan horse’ strategy. Trends Pharmacol Sci 35:442–449
Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62:316–330
Haas H, Petrik M, Decristoforo C (2015) An iron-mimicking, Trojan horse-entering fungi—has
the time come for molecular imaging of fungal infections? PLoS Pathog 11:e1004568
Hissen AHT, Wan ANC, Warwas ML et al (2005) The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence. Infect Immun
73:5493–5503
Horbach R, Graf A, Weihmann F et al (2009) Sfp-type 4′-phosphopantetheinyl transferase is indispensable for fungal pathogenicity. Plant Cell 21:3379–3396
2 Inhibition of Siderophores in Blocking Fungal Infection
Beck-Sagué C, Dooley SW, Hutton MD et al (1992) Hospital outbreak of multidrug-resistant
Mycobacterium tuberculosis infections: factors in transmission to staff and HIV-infected
patients. JAMA 268:1280–1286
Bernier G, Girijavallabhan V, Murray A et al (2005) Desketoneoenactin-siderophore conjugates
for Candida: evidence of iron transport-dependent species selectivity. Antimicrob Agents
Chemother 49:241–248
Blatzer M, Schrettl M, Sarg B et al (2011) SidL an Aspergillus fumigatus transacetylase involved
in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. Appl Environ Microbiol
77:4959–4966
Braun V, Pramanik A, Gwinner T et al (2009) Sideromycins: tools and antibiotics. Biometals
22:3–13
Chamilos G, Lewis RE, Kontoyiannis DP (2006) Lovastatin has significant activity against
zygomycetes and interacts synergistically with voriconazole. Antimicrob Agents Chemother
50:96–103
Chaudhary AS (2016) A review of global initiatives to fight antibiotic resistance and recent antibiotics’ discovery. Acta Pharm Sin B 6:552–556
Cisar JS, Ferreras JA, Soni RK et al (2007) Exploiting ligand conformation in selective inhibition
of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small
molecules. J Am Chem Soc 129:7752–7753
Clatworthy AE, Pierson E, Hung DT (2007) Targeting virulence: a new paradigm for antimicrobial
therapy. Nat Chem Biol 3:541–548
Cornelis P, Matthijs S (2002) Diversity of siderophore-mediated iron uptake systems in fluorescent
pseudomonads: not only pyoverdines. Environ Microbiol 4:787–798
da Silva ACR, Ferro JA, Reinach FC et al (2002) Comparison of the genomes of two Xanthomonas
pathogens with differing host specificities. Nature 417:459–463
Eisendle M, Oberegger H, Zadra I et al (2003) The siderophore system is essential for viability of
Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5- monooxygenase
(sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 49:359–375
Farkas V (1985) The fungal cell wall. In: Fungal protoplasts: applications in biochemistry genetics.
Marcel Dekker, New York/Basel, pp 3–29
Farkas E, Szabó O, Gyémánt G et al (2018) Complexation of hydroxamate-based siderophores
with cobalt (II/III): growth inhibitory effect of cobalt (III)-desferricoprogen complex on fungi.
Transit Met Chem 43:355–365
Ferreras JA, Ryu JS, Di Lello F et al (2005) Small-molecule inhibition of siderophore biosynthesis
in Mycobacterium tuberculosis and Yersinia pestis. Nat Chem Biol 1:29–32
Finking R, Neumüller A, Solsbacher J et al (2003) Aminoacyl adenylate substrate analogues for
the inhibition of adenylation domains of nonribosomal peptide synthetases. Chem Bio Chem
4:903–906
Galgóczy L, Nyilasi I, Papp T et al (2009) Are statins applicable for the prevention and treatment
of zygomycosis? Clin Infect Dis 49:483–484
Gootz TD (2010) The global problem of antibiotic resistance. Crit Rev Immunol 30:79–93
Górska A, Sloderbach A, Marszałł MP (2014) Siderophore–drug complexes: potential medicinal
applications of the ‘Trojan horse’ strategy. Trends Pharmacol Sci 35:442–449
Haas H (2003) Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl Microbiol Biotechnol 62:316–330
Haas H, Petrik M, Decristoforo C (2015) An iron-mimicking, Trojan horse-entering fungi—has
the time come for molecular imaging of fungal infections? PLoS Pathog 11:e1004568
Hissen AHT, Wan ANC, Warwas ML et al (2005) The Aspergillus fumigatus siderophore biosynthetic gene sidA, encoding L-ornithine N5-oxygenase, is required for virulence. Infect Immun
73:5493–5503
Horbach R, Graf A, Weihmann F et al (2009) Sfp-type 4′-phosphopantetheinyl transferase is indispensable for fungal pathogenicity. Plant Cell 21:3379–3396
2 Inhibition of Siderophores in Blocking Fungal Infection