113
Table 7.4 (continued)
Sl.
no. Area
Description
4. Nuclear fuel
reprocessing
Desferrioxamine B (hydroxamate and catecholate
functionalities) is supposed to form strong complexes and have
high-stability constants due to hard oxygen anions which help in
separation of contaminants (acetanilide) during Purex process
(fuel reprocessing)
5. Bioremediation of
environmental pollutant
Due to high affinity of siderophore towards metal ions such as
Cd, Zn, Cu, Ni, and Pb, siderophores are extremely effective in
solubilizing and increasing mobility of these metals and possess
strong affinity to form stable complexes, thus making it useful in
bioremediation
6. Bio-bleaching of pulps
Siderophore (isolated from Gloeophyllum trabeum) effectively
reduces the proportion of chemical used in bleaching process
and can be an environment-friendly approach
7. Siderophore promotes
plant growth
Siderophores provide nutrition in form of iron to support their
growth when the bioavailability of iron is low
8. Soil mineral weathering Siderophores help in protecting microbes against environmental
stress by adhering to mineral surfaces
9. Biogeochemical cycling
of iron in the ocean
Siderophores make the iron available to phytoplankton in
marine waters which plays an important role in their growth
Biomedical applications
10. Selective drug deliveryTrojan Horse strategy
Development of siderophore-antibiotic conjugates called
‘sideromycins’
11. Treatment of disease
condition with iron
overloading
Effective in conditions like haemochromatosis, sickle cell
disease and thalassemia (major)
12. Management of Malaria Siderophore (such as desferrioxamine B) produced by
Streptomyces pilosus has activity against P. falciparum (in vitro
and in vivo)
13. Removal of overload of
transuranic elements like
aluminium and
vanadium
Siderophore named Desferal interacts with aluminium and
vanadium ions and forms complexes which are readily excreted
from the body via urine and faeces
14. Cancer therapy
Several siderophores such as dexrazoxane, O-trensox,
desferriexochelins and desferrithiocin are found to be effective
in cancer therapy
15. Antidote for iron
poisoning
Deferoxamine B is used as antidote in acute iron poisoning and
high iron loading conditions such as thalassaemia major and
aluminium poisoning in chronic renal dialysis. Deferoxamine B
is considered to have a high binding affinity for ferric form of
iron that helps in removing excess iron from tissues and
circulatory system
7 Contrasting Role of Fungal Siderophore in Metal Ion Complex Formation
Table 7.4 (continued)
Sl.
no. Area
Description
4. Nuclear fuel
reprocessing
Desferrioxamine B (hydroxamate and catecholate
functionalities) is supposed to form strong complexes and have
high-stability constants due to hard oxygen anions which help in
separation of contaminants (acetanilide) during Purex process
(fuel reprocessing)
5. Bioremediation of
environmental pollutant
Due to high affinity of siderophore towards metal ions such as
Cd, Zn, Cu, Ni, and Pb, siderophores are extremely effective in
solubilizing and increasing mobility of these metals and possess
strong affinity to form stable complexes, thus making it useful in
bioremediation
6. Bio-bleaching of pulps
Siderophore (isolated from Gloeophyllum trabeum) effectively
reduces the proportion of chemical used in bleaching process
and can be an environment-friendly approach
7. Siderophore promotes
plant growth
Siderophores provide nutrition in form of iron to support their
growth when the bioavailability of iron is low
8. Soil mineral weathering Siderophores help in protecting microbes against environmental
stress by adhering to mineral surfaces
9. Biogeochemical cycling
of iron in the ocean
Siderophores make the iron available to phytoplankton in
marine waters which plays an important role in their growth
Biomedical applications
10. Selective drug deliveryTrojan Horse strategy
Development of siderophore-antibiotic conjugates called
‘sideromycins’
11. Treatment of disease
condition with iron
overloading
Effective in conditions like haemochromatosis, sickle cell
disease and thalassemia (major)
12. Management of Malaria Siderophore (such as desferrioxamine B) produced by
Streptomyces pilosus has activity against P. falciparum (in vitro
and in vivo)
13. Removal of overload of
transuranic elements like
aluminium and
vanadium
Siderophore named Desferal interacts with aluminium and
vanadium ions and forms complexes which are readily excreted
from the body via urine and faeces
14. Cancer therapy
Several siderophores such as dexrazoxane, O-trensox,
desferriexochelins and desferrithiocin are found to be effective
in cancer therapy
15. Antidote for iron
poisoning
Deferoxamine B is used as antidote in acute iron poisoning and
high iron loading conditions such as thalassaemia major and
aluminium poisoning in chronic renal dialysis. Deferoxamine B
is considered to have a high binding affinity for ferric form of
iron that helps in removing excess iron from tissues and
circulatory system
7 Contrasting Role of Fungal Siderophore in Metal Ion Complex Formation