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chronic oxidative stress and their potential therapeutic implications in humans. Experimental
Physiology, 94(3), 305–310.
125. Vanhoutte, P. M., Feletou, M., & Taddei, S. (2005). Endothelium-dependent contractions in
hypertension. British Journal of Pharmacology, 144(4), 449–458.
126. Varga, R., et al. (2006). Progressive vascular smooth muscle cell defects in a mouse model of
Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences of
the United States of America, 103(9), 3250–3255.
127. Victorelli, S., & Passos, J. F. (2017). Telomeres and cell senescence - size matters not. eBioMedicine, 21, 14–20.
128. Villa-Bellosta, R., et al. (2013). Defective extracellular pyrophosphate metabolism promotes
vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is
ameliorated on pyrophosphate treatment. Circulation, 127(24), 2442–2451.
129. Wagenseil, J. E., & Mecham, R. P. (2009). Vascular extracellular matrix and arterial mechanics. Physiological Reviews, 89(3), 957–989.
130. Wang, M., et al. (2006). Matrix metalloproteinase 2 activation of transforming growth factorbeta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall.
Arteriosclerosis, Thrombosis, and Vascular Biology, 26(7), 1503–1509.
131. Wang, M., et al. (2014). Proinflammation: The key to arterial aging. Trends in Endocrinology
and Metabolism, 25(2), 72–79.
132. Wang, M., et al. (2015). Matrix metalloproteinases promote arterial remodeling in aging,
hypertension, and atherosclerosis. Hypertension, 65(4), 698–703.
133. Wong, A. D., & Searson, P. C. (2014). Live-cell imaging of invasion and intravasation in an
artificial microvessel platform. Cancer Research, 74(17), 4937–4945.
134. Wu, Z., et al. (2015). Role of p38 mitogen-activated protein kinase in vascular endothelial
aging: Interaction with Arginase-II and S6K1 signaling pathway. Aging (Albany NY), 7(1),
70–81.
135. Wynn, T. A. (2008). Cellular and molecular mechanisms of fibrosis. The Journal of Pathology,
214(2), 199–210.
136. Xu, J., & Shi, G. P. (2014). Vascular wall extracellular matrix proteins and vascular diseases.
Biochimica et Biophysica Acta, 1842(11), 2106–2119.
137. Yang, S. H., et al. (2005). Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
Proceedings of the National Academy of Sciences of the United States of America, 102(29),
10291–10296.
138. Zhang, H. Y., Xiong, Z. M., & Cao, K. (2014). Mechanisms controlling the smooth muscle
cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. Proceedings of
the National Academy of Sciences of the United States of America, 111(22), E2261–E2270.
139. Zhang, J., et al. (2011). A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell, 8(1), 31–45.
P. R. Pitrez et al.
124. van der Loo, B., et al. (2009). Signalling processes in endothelial ageing in relation to
chronic oxidative stress and their potential therapeutic implications in humans. Experimental
Physiology, 94(3), 305–310.
125. Vanhoutte, P. M., Feletou, M., & Taddei, S. (2005). Endothelium-dependent contractions in
hypertension. British Journal of Pharmacology, 144(4), 449–458.
126. Varga, R., et al. (2006). Progressive vascular smooth muscle cell defects in a mouse model of
Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences of
the United States of America, 103(9), 3250–3255.
127. Victorelli, S., & Passos, J. F. (2017). Telomeres and cell senescence - size matters not. eBioMedicine, 21, 14–20.
128. Villa-Bellosta, R., et al. (2013). Defective extracellular pyrophosphate metabolism promotes
vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is
ameliorated on pyrophosphate treatment. Circulation, 127(24), 2442–2451.
129. Wagenseil, J. E., & Mecham, R. P. (2009). Vascular extracellular matrix and arterial mechanics. Physiological Reviews, 89(3), 957–989.
130. Wang, M., et al. (2006). Matrix metalloproteinase 2 activation of transforming growth factorbeta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall.
Arteriosclerosis, Thrombosis, and Vascular Biology, 26(7), 1503–1509.
131. Wang, M., et al. (2014). Proinflammation: The key to arterial aging. Trends in Endocrinology
and Metabolism, 25(2), 72–79.
132. Wang, M., et al. (2015). Matrix metalloproteinases promote arterial remodeling in aging,
hypertension, and atherosclerosis. Hypertension, 65(4), 698–703.
133. Wong, A. D., & Searson, P. C. (2014). Live-cell imaging of invasion and intravasation in an
artificial microvessel platform. Cancer Research, 74(17), 4937–4945.
134. Wu, Z., et al. (2015). Role of p38 mitogen-activated protein kinase in vascular endothelial
aging: Interaction with Arginase-II and S6K1 signaling pathway. Aging (Albany NY), 7(1),
70–81.
135. Wynn, T. A. (2008). Cellular and molecular mechanisms of fibrosis. The Journal of Pathology,
214(2), 199–210.
136. Xu, J., & Shi, G. P. (2014). Vascular wall extracellular matrix proteins and vascular diseases.
Biochimica et Biophysica Acta, 1842(11), 2106–2119.
137. Yang, S. H., et al. (2005). Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.
Proceedings of the National Academy of Sciences of the United States of America, 102(29),
10291–10296.
138. Zhang, H. Y., Xiong, Z. M., & Cao, K. (2014). Mechanisms controlling the smooth muscle
cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. Proceedings of
the National Academy of Sciences of the United States of America, 111(22), E2261–E2270.
139. Zhang, J., et al. (2011). A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell, 8(1), 31–45.
P. R. Pitrez et al.