71
100. Rosenbloom, J., Abrams, W. R., & Mecham, R. (1993). Extracellular matrix 4: The elastic
fiber. The FASEB Journal, 7(13), 1208–1218.
101. Ross, C. A., & Poirier, M. A. (2004). Protein aggregation and neurodegenerative disease.
Nature Medicine, 10(7), S10–S17.
102. Ryan, A. J., et al. (2016). Towards 3D in vitro models for the study of cardiovascular tissues
and disease. Drug Discovery Today, 21(9), 1437–1445.
103. Scaffidi, P., & Misteli, T. (2006). Lamin A-dependent nuclear defects in human aging.
Science, 312(5776), 1059–1063.
104. Schleicher, E. D., Wagner, E., & Nerlich, A. G. (1997). Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
The Journal of Clinical Investigation, 99(3), 457–468.
105. Schrage, W. G., Eisenach, J. H., & Joyner, M. J. (2007). Ageing reduces nitric-oxide- and
prostaglandin-mediated vasodilatation in exercising humans. The Journal of Physiology,
579(Pt 1), 227–236.
106. Seals, D. R., et al. (2006). Modulatory influences on ageing of the vasculature in healthy
humans. Experimental Gerontology, 41(5), 501–507.
107. Senatus, L. M., & Schmidt, A. M. (2017). The AGE-RAGE Axis: Implications for ageassociated arterial diseases. Frontiers in Genetics, 8, 187.
108. Shao, J., et al. (2009). Integrated microfluidic chip for endothelial cells culture and analysis
exposed to a pulsatile and oscillatory shear stress. Lab on a Chip, 9(21), 3118–3125.
109. Shi, Z. D., & Tarbell, J. M. (2011). Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts. Annals of Biomedical Engineering, 39(6), 1608–1619.
110. Song, J. W., et al. (2005). Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Analytical Chemistry, 77(13), 3993–3999.
111. Song, M. J., et al. (2014). Shear stress-induced mechanotransduction protein deregulation
and vasculopathy in a mouse model of progeria. Stem Cell Research & Therapy, 5(2), 41.
112. Stuehr, D., Pou, S., & Rosen, G. M. (2001). Oxygen reduction by nitric-oxide synthases. The
Journal of Biological Chemistry, 276(18), 14533–14536.
113. Taddei, S., et al. (1997). Hypertension causes premature aging of endothelial function in
humans. Hypertension, 29(3), 736–743.
114. Tam, J., et al. (2014). A microfluidic platform for correlative live-cell and super-resolution
microscopy. PLoS One, 9(12), e115512.
115. Tian, X. L., & Li, Y. (2014). Endothelial cell senescence and age-related vascular diseases.
Journal of Genetics and Genomics, 41(9), 485–495.
116. Toda, N. (2012). Age-related changes in endothelial function and blood flow regulation.
Pharmacology & Therapeutics, 133(2), 159–176.
117. Tsamis, A., Krawiec, J. T., & Vorp, D. A. (2013). Elastin and collagen fibre microstructure
of the human aorta in ageing and disease: A review. Journal of the Royal Society Interface,
10(83), 20121004.
118. Tsamis, A., Rachev, A., & Stergiopulos, N. (2011). A constituent-based model of agerelated changes in conduit arteries. American Journal of Physiology. Heart and Circulatory
Physiology, 301(4), H1286–H1301.
119. Tsioufis, C., et al. (2007). Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients. European Heart
Journal, 28(9), 1162–1169.
120. Ungvari, Z., et al. (2011). Vascular oxidative stress in aging: A homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. American Journal of Physiology. Heart
and Circulatory Physiology, 301(2), H363–H372.
121. United Nations, D.E.S.A.P.D. (2015). World Population Ageing 2015.
122. Valko, M., et al. (2007). Free radicals and antioxidants in normal physiological functions and
human disease. The International Journal of Biochemistry & Cell Biology, 39(1), 44–84.
123. van der Loo, B., et al. (2000). Enhanced peroxynitrite formation is associated with vascular
aging. The Journal of Experimental Medicine, 192(12), 1731–1744.
3 Physiological and Pathological Vascular Aging
100. Rosenbloom, J., Abrams, W. R., & Mecham, R. (1993). Extracellular matrix 4: The elastic
fiber. The FASEB Journal, 7(13), 1208–1218.
101. Ross, C. A., & Poirier, M. A. (2004). Protein aggregation and neurodegenerative disease.
Nature Medicine, 10(7), S10–S17.
102. Ryan, A. J., et al. (2016). Towards 3D in vitro models for the study of cardiovascular tissues
and disease. Drug Discovery Today, 21(9), 1437–1445.
103. Scaffidi, P., & Misteli, T. (2006). Lamin A-dependent nuclear defects in human aging.
Science, 312(5776), 1059–1063.
104. Schleicher, E. D., Wagner, E., & Nerlich, A. G. (1997). Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
The Journal of Clinical Investigation, 99(3), 457–468.
105. Schrage, W. G., Eisenach, J. H., & Joyner, M. J. (2007). Ageing reduces nitric-oxide- and
prostaglandin-mediated vasodilatation in exercising humans. The Journal of Physiology,
579(Pt 1), 227–236.
106. Seals, D. R., et al. (2006). Modulatory influences on ageing of the vasculature in healthy
humans. Experimental Gerontology, 41(5), 501–507.
107. Senatus, L. M., & Schmidt, A. M. (2017). The AGE-RAGE Axis: Implications for ageassociated arterial diseases. Frontiers in Genetics, 8, 187.
108. Shao, J., et al. (2009). Integrated microfluidic chip for endothelial cells culture and analysis
exposed to a pulsatile and oscillatory shear stress. Lab on a Chip, 9(21), 3118–3125.
109. Shi, Z. D., & Tarbell, J. M. (2011). Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts. Annals of Biomedical Engineering, 39(6), 1608–1619.
110. Song, J. W., et al. (2005). Computer-controlled microcirculatory support system for endothelial cell culture and shearing. Analytical Chemistry, 77(13), 3993–3999.
111. Song, M. J., et al. (2014). Shear stress-induced mechanotransduction protein deregulation
and vasculopathy in a mouse model of progeria. Stem Cell Research & Therapy, 5(2), 41.
112. Stuehr, D., Pou, S., & Rosen, G. M. (2001). Oxygen reduction by nitric-oxide synthases. The
Journal of Biological Chemistry, 276(18), 14533–14536.
113. Taddei, S., et al. (1997). Hypertension causes premature aging of endothelial function in
humans. Hypertension, 29(3), 736–743.
114. Tam, J., et al. (2014). A microfluidic platform for correlative live-cell and super-resolution
microscopy. PLoS One, 9(12), e115512.
115. Tian, X. L., & Li, Y. (2014). Endothelial cell senescence and age-related vascular diseases.
Journal of Genetics and Genomics, 41(9), 485–495.
116. Toda, N. (2012). Age-related changes in endothelial function and blood flow regulation.
Pharmacology & Therapeutics, 133(2), 159–176.
117. Tsamis, A., Krawiec, J. T., & Vorp, D. A. (2013). Elastin and collagen fibre microstructure
of the human aorta in ageing and disease: A review. Journal of the Royal Society Interface,
10(83), 20121004.
118. Tsamis, A., Rachev, A., & Stergiopulos, N. (2011). A constituent-based model of agerelated changes in conduit arteries. American Journal of Physiology. Heart and Circulatory
Physiology, 301(4), H1286–H1301.
119. Tsioufis, C., et al. (2007). Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients. European Heart
Journal, 28(9), 1162–1169.
120. Ungvari, Z., et al. (2011). Vascular oxidative stress in aging: A homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. American Journal of Physiology. Heart
and Circulatory Physiology, 301(2), H363–H372.
121. United Nations, D.E.S.A.P.D. (2015). World Population Ageing 2015.
122. Valko, M., et al. (2007). Free radicals and antioxidants in normal physiological functions and
human disease. The International Journal of Biochemistry & Cell Biology, 39(1), 44–84.
123. van der Loo, B., et al. (2000). Enhanced peroxynitrite formation is associated with vascular
aging. The Journal of Experimental Medicine, 192(12), 1731–1744.
3 Physiological and Pathological Vascular Aging