70
79. Meschiari, C. A., et al. (2017). The impact of aging on cardiac extracellular matrix.
Geroscience, 39(1), 7–18.
80. Minamino, T. (2002). Endothelial cell senescence in human atherosclerosis: Role of telomere
in endothelial dysfunction. Circulation, 105(13), 1541–1544.
81. Monaco, C., et al. (2004). Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America, 101(15),
5634–5639.
82. Nakano-Kurimoto, R., et al. (2009). Replicative senescence of vascular smooth muscle cells
enhances the calcification through initiating the osteoblastic transition. American Journal of
Physiology. Heart and Circulatory Physiology, 297(5), H1673–H1684.
83. Newaz, M. A., Yousefipour, Z., & Oyekan, A. (2006). Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent. Journal of
Cardiovascular Pharmacology, 48(3), 88–94.
84. Niccoli, T., & Partridge, L. (2012). Ageing as a risk factor for disease. Current Biology,
22(17), R741–R752.
85. O'Connell, M. K., et al. (2008). The three-dimensional micro- and nanostructure of the aortic
medial lamellar unit measured using 3D confocal and electron microscopy imaging. Matrix
Biology, 27(3), 171–181.
86. Olive, M., et al. (2010). Cardiovascular pathology in Hutchinson-Gilford progeria:
Correlation with the vascular pathology of aging. Arteriosclerosis Thrombosis and Vascular
Biology, 30(11), 2301–U636.
87. Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C.,
et al. (2011). Splicing-directed therapy in a new mouse model of human accelerated aging.
Science Translational Medicine, 3(106), 106ra107.
88. Paneni, F., et al. (2017). The aging cardiovascular system understanding it at the cellular and
clinical levels. Journal of the American College of Cardiology, 69(15), 1952–1967.
89. Petersen-Jones, H. G., et al. (2015). Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. American Journal of
Physiology. Heart and Circulatory Physiology, 308(6), H592–H602.
90. Philip, J. T., & Dahl, K. N. (2008). Nuclear mechanotransduction: Response of the lamina to
extracellular stress with implications in aging. Journal of Biomechanics, 41(15), 3164–3170.
91. Prakobwong, S., et al. (2010). Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model. International Journal
of Cancer, 127(11), 2576–2587.
92. Price, G. M., & Tien, J. (2011). Methods for forming human microvascular tubes in vitro and
measuring their macromolecular permeability. Methods in Molecular Biology, 671, 281–293.
93. Prinzinger, R. (2005). Programmed ageing: The theory of maximal metabolic scope. How
does the biological clock tick? EMBO Reports, 6(Suppl 1), S14–S19.
94. Qin, X., et al. (2006). Matrix metalloproteinase inhibition attenuates aortic calcification.
Arteriosclerosis Thrombosis and Vascular Biology, 26(7), 1510–1516.
95. Redon, C. E., et al. (2011). Recent developments in the use of γ -H2AX as a quantitative
DNA double-strand break biomarker. Aging, 3(2), 168–174.
96. Reiser, K., McCormick, R. J., & Rucker, R. B. (1992). Enzymatic and nonenzymatic crosslinking of collagen and elastin. The FASEB Journal, 6(7), 2439–2449.
97. Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J., Miscuglio, M., Rouwkema, J., et al. (2017).
Biomechanical strain exacerbates inflammation on a progeria-on-a-chip model. Small,
13(15). https://doi.org/10.1002/smll.201603737
98. Rice, K. M., et al. (2005). Effects of aging on pressure-induced MAPK activation in the rat
aorta. Pflügers Archiv, 450(3), 192–199.
99. Rodriguez-Manas, L., et al. (2009). Endothelial dysfunction in aged humans is related with
oxidative stress and vascular inflammation. Aging Cell, 8(3), 226–238.
P. R. Pitrez et al.
79. Meschiari, C. A., et al. (2017). The impact of aging on cardiac extracellular matrix.
Geroscience, 39(1), 7–18.
80. Minamino, T. (2002). Endothelial cell senescence in human atherosclerosis: Role of telomere
in endothelial dysfunction. Circulation, 105(13), 1541–1544.
81. Monaco, C., et al. (2004). Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America, 101(15),
5634–5639.
82. Nakano-Kurimoto, R., et al. (2009). Replicative senescence of vascular smooth muscle cells
enhances the calcification through initiating the osteoblastic transition. American Journal of
Physiology. Heart and Circulatory Physiology, 297(5), H1673–H1684.
83. Newaz, M. A., Yousefipour, Z., & Oyekan, A. (2006). Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent. Journal of
Cardiovascular Pharmacology, 48(3), 88–94.
84. Niccoli, T., & Partridge, L. (2012). Ageing as a risk factor for disease. Current Biology,
22(17), R741–R752.
85. O'Connell, M. K., et al. (2008). The three-dimensional micro- and nanostructure of the aortic
medial lamellar unit measured using 3D confocal and electron microscopy imaging. Matrix
Biology, 27(3), 171–181.
86. Olive, M., et al. (2010). Cardiovascular pathology in Hutchinson-Gilford progeria:
Correlation with the vascular pathology of aging. Arteriosclerosis Thrombosis and Vascular
Biology, 30(11), 2301–U636.
87. Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C.,
et al. (2011). Splicing-directed therapy in a new mouse model of human accelerated aging.
Science Translational Medicine, 3(106), 106ra107.
88. Paneni, F., et al. (2017). The aging cardiovascular system understanding it at the cellular and
clinical levels. Journal of the American College of Cardiology, 69(15), 1952–1967.
89. Petersen-Jones, H. G., et al. (2015). Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. American Journal of
Physiology. Heart and Circulatory Physiology, 308(6), H592–H602.
90. Philip, J. T., & Dahl, K. N. (2008). Nuclear mechanotransduction: Response of the lamina to
extracellular stress with implications in aging. Journal of Biomechanics, 41(15), 3164–3170.
91. Prakobwong, S., et al. (2010). Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model. International Journal
of Cancer, 127(11), 2576–2587.
92. Price, G. M., & Tien, J. (2011). Methods for forming human microvascular tubes in vitro and
measuring their macromolecular permeability. Methods in Molecular Biology, 671, 281–293.
93. Prinzinger, R. (2005). Programmed ageing: The theory of maximal metabolic scope. How
does the biological clock tick? EMBO Reports, 6(Suppl 1), S14–S19.
94. Qin, X., et al. (2006). Matrix metalloproteinase inhibition attenuates aortic calcification.
Arteriosclerosis Thrombosis and Vascular Biology, 26(7), 1510–1516.
95. Redon, C. E., et al. (2011). Recent developments in the use of γ -H2AX as a quantitative
DNA double-strand break biomarker. Aging, 3(2), 168–174.
96. Reiser, K., McCormick, R. J., & Rucker, R. B. (1992). Enzymatic and nonenzymatic crosslinking of collagen and elastin. The FASEB Journal, 6(7), 2439–2449.
97. Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J., Miscuglio, M., Rouwkema, J., et al. (2017).
Biomechanical strain exacerbates inflammation on a progeria-on-a-chip model. Small,
13(15). https://doi.org/10.1002/smll.201603737
98. Rice, K. M., et al. (2005). Effects of aging on pressure-induced MAPK activation in the rat
aorta. Pflügers Archiv, 450(3), 192–199.
99. Rodriguez-Manas, L., et al. (2009). Endothelial dysfunction in aged humans is related with
oxidative stress and vascular inflammation. Aging Cell, 8(3), 226–238.
P. R. Pitrez et al.