68
33. Duca, L., et al. (2016). Matrix ageing and vascular impacts: Focus on elastin fragmentation.
Cardiovascular Research, 110(3), 298–308.
34. Dudinskaya, E. N., et al. (2015). Short telomere length is associated with arterial aging in
patients with type 2 diabetes mellitus. Endocrine Connections, 4(3), 136–143.
35. El Assar, M., Angulo, J., & Rodriguez-Manas, L. (2013). Oxidative stress and vascular
inflammation in aging. Free Radical Biology & Medicine, 65, 380–401.
36. Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., et al. (2003).
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.
Nature, 423(6937), 293–298.
37. Esch, E. W., Bahinski, A., & Huh, D. (2015). Organs-on-chips at the frontiers of drug discovery. Nature Reviews. Drug Discovery, 14(4), 248–260.
38. Fitzgerald, K. A., et al. (2015). Life in 3D is never flat: 3D models to optimise drug delivery.
Journal of Controlled Release, 215, 39–54.
39. Fleenor, B. S., et al. (2010). Arterial stiffening with ageing is associated with transforming
growth factor-beta1-related changes in adventitial collagen: Reversal by aerobic exercise.
The Journal of Physiology, 588(Pt 20), 3971–3982.
40. Freund, A., et al. (2012). Lamin B1 loss is a senescence-associated biomarker. Molecular
Biology of the Cell, 23(11), 2066–2075.
41. Fujimoto, D. (1982). Aging and cross-linking in human aorta. Biochemical and Biophysical
Research Communications, 109(4), 1264–1269.
42. Fyhrquist, F., Saijonmaa, O., & Strandberg, T. (2013). The roles of senescence and telomere
shortening in cardiovascular disease. Nature Reviews. Cardiology, 10(5), 274–283.
43. Goldin, A., et al. (2006). Advanced glycation end products: Sparking the development of
diabetic vascular injury. Circulation, 114(6), 597–605.
44. Gonzalo, S., Kreienkamp, R., & Askjaer, P. (2017). Hutchinson-Gilford Progeria Syndrome:
A premature aging disease caused by LMNA gene mutations. Ageing Research Reviews, 33,
18–29.
45. Guzik, T. J., et al. (2002). Mechanisms of increased vascular superoxide production in
human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Circulation, 105(14), 1656–1662.
46. Hadden, W. J., et al. (2017). Stem cell migration and mechanotransduction on linear stiffness
gradient hydrogels. Proceedings of the National Academy of Sciences of the United States of
America, 114(22), 5647–5652.
47. Hamczyk, M. R., del Campo, L., & Andrés, V. (2017). Aging in the cardiovascular system:
Lessons from Hutchinson-Gilford progeria syndrome. Annual Review of Physiology, 80,
27–48.
48. Hamilton, C. A., et al. (2001). Superoxide excess in hypertension and aging: A common
cause of endothelial dysfunction. Hypertension, 37(2 Pt 2), 529–534.
49. Hampel, B., et al. (2006). Increased expression of extracellular proteins as a hallmark of
human endothelial cell in vitro senescence. Experimental Gerontology, 41(5), 474–481.
50. Harten, I. A., et al. (2011). Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome. Journals of Gerontology Series a-Biological Sciences and Medical Sciences,
66(11), 1201–1207.
51. Harvey, A., et al. (2016). Vascular fibrosis in aging and hypertension: Molecular mechanisms
and clinical implications. The Canadian Journal of Cardiology, 32(5), 659–668.
52. Hayflick, L. (2000). The illusion of cell immortality. British Journal of Cancer, 83(7),
841–846.
53. Hernandez, L., et al. (2010). Functional coupling between the extracellular matrix and
nuclear lamina by Wnt signaling in progeria. Developmental Cell, 19(3), 413–425.
54. Jacob, M. P. (2003). Extracellular matrix remodeling and matrix metalloproteinases in the
vascular wall during aging and in pathological conditions. Biomedicine & Pharmacotherapy,
57(5–6), 195–202.
55. Jin, K. (2010). Modern biological theories of aging. Aging and Disease, 1(2), 72–74.
P. R. Pitrez et al.
33. Duca, L., et al. (2016). Matrix ageing and vascular impacts: Focus on elastin fragmentation.
Cardiovascular Research, 110(3), 298–308.
34. Dudinskaya, E. N., et al. (2015). Short telomere length is associated with arterial aging in
patients with type 2 diabetes mellitus. Endocrine Connections, 4(3), 136–143.
35. El Assar, M., Angulo, J., & Rodriguez-Manas, L. (2013). Oxidative stress and vascular
inflammation in aging. Free Radical Biology & Medicine, 65, 380–401.
36. Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., et al. (2003).
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.
Nature, 423(6937), 293–298.
37. Esch, E. W., Bahinski, A., & Huh, D. (2015). Organs-on-chips at the frontiers of drug discovery. Nature Reviews. Drug Discovery, 14(4), 248–260.
38. Fitzgerald, K. A., et al. (2015). Life in 3D is never flat: 3D models to optimise drug delivery.
Journal of Controlled Release, 215, 39–54.
39. Fleenor, B. S., et al. (2010). Arterial stiffening with ageing is associated with transforming
growth factor-beta1-related changes in adventitial collagen: Reversal by aerobic exercise.
The Journal of Physiology, 588(Pt 20), 3971–3982.
40. Freund, A., et al. (2012). Lamin B1 loss is a senescence-associated biomarker. Molecular
Biology of the Cell, 23(11), 2066–2075.
41. Fujimoto, D. (1982). Aging and cross-linking in human aorta. Biochemical and Biophysical
Research Communications, 109(4), 1264–1269.
42. Fyhrquist, F., Saijonmaa, O., & Strandberg, T. (2013). The roles of senescence and telomere
shortening in cardiovascular disease. Nature Reviews. Cardiology, 10(5), 274–283.
43. Goldin, A., et al. (2006). Advanced glycation end products: Sparking the development of
diabetic vascular injury. Circulation, 114(6), 597–605.
44. Gonzalo, S., Kreienkamp, R., & Askjaer, P. (2017). Hutchinson-Gilford Progeria Syndrome:
A premature aging disease caused by LMNA gene mutations. Ageing Research Reviews, 33,
18–29.
45. Guzik, T. J., et al. (2002). Mechanisms of increased vascular superoxide production in
human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Circulation, 105(14), 1656–1662.
46. Hadden, W. J., et al. (2017). Stem cell migration and mechanotransduction on linear stiffness
gradient hydrogels. Proceedings of the National Academy of Sciences of the United States of
America, 114(22), 5647–5652.
47. Hamczyk, M. R., del Campo, L., & Andrés, V. (2017). Aging in the cardiovascular system:
Lessons from Hutchinson-Gilford progeria syndrome. Annual Review of Physiology, 80,
27–48.
48. Hamilton, C. A., et al. (2001). Superoxide excess in hypertension and aging: A common
cause of endothelial dysfunction. Hypertension, 37(2 Pt 2), 529–534.
49. Hampel, B., et al. (2006). Increased expression of extracellular proteins as a hallmark of
human endothelial cell in vitro senescence. Experimental Gerontology, 41(5), 474–481.
50. Harten, I. A., et al. (2011). Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome. Journals of Gerontology Series a-Biological Sciences and Medical Sciences,
66(11), 1201–1207.
51. Harvey, A., et al. (2016). Vascular fibrosis in aging and hypertension: Molecular mechanisms
and clinical implications. The Canadian Journal of Cardiology, 32(5), 659–668.
52. Hayflick, L. (2000). The illusion of cell immortality. British Journal of Cancer, 83(7),
841–846.
53. Hernandez, L., et al. (2010). Functional coupling between the extracellular matrix and
nuclear lamina by Wnt signaling in progeria. Developmental Cell, 19(3), 413–425.
54. Jacob, M. P. (2003). Extracellular matrix remodeling and matrix metalloproteinases in the
vascular wall during aging and in pathological conditions. Biomedicine & Pharmacotherapy,
57(5–6), 195–202.
55. Jin, K. (2010). Modern biological theories of aging. Aging and Disease, 1(2), 72–74.
P. R. Pitrez et al.