185
inflammation on angiogenesis-induced tissue repair. Taken together, a tissue engineering approach to provascular therapies presents challenges that need to be overcome, before provascular materials are a valuable alternative for the clinical
treatment of brain damage.
References
1. Abe, K., Setoguchi, Y., Hayashi, T., & Itoyama, Y. (1997). Dissociative expression of adenoviralmediated E. coli LacZ gene between ischemic and reperfused rat brains. Neuroscience Letters,
226, 53–56.
2. Allen, C. M. (1984). Predicting the outcome of acute stroke: A prognostic score. Journal of
Neurology, Neurosurgery, and Psychiatry, 47, 475–480.
3. Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., et al. (2016).
Astrocyte scar formation aids central nervous system axon regeneration. Nature, 532,
195–200.
4. Anderson, S. M., Siegman, S. N., & Segura, T. (2011). The effect of vascular endothelial
growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching.
Biomaterials, 32, 7432–7443.
5. Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., et al. (2017).
Heart disease and stroke statistics-2017 update: A report from the American Heart Association.
Circulation, 135, e146–e603.
6. Bible, E., Qutachi, O., Chau, D. Y. S., Alexander, M. R., Shakesheff, K. M., & Modo, M.
(2012). Neo-vascularization of the stroke cavity by implantation of human neural stem cells
on VEGF-releasing PLGA microparticles. Biomaterials, 33, 7435–7346.
7. Castellanos, M., Sobrino, T., & Castillo, J. (2006). Evolving paradigms for neuroprotection:
Molecular identification of ischemic penumbra. Cerebrovascular Diseases, 21(Suppl 2),
71–79.
8. Chopp, M., Li, Y., & Zhang, J. (2008). Plasticity and remodeling of brain. Journal of the
Neurological Sciences, 265, 97–101.
9. del Zoppo, G. J., & Mabuchi, T. (2003). Cerebral microvessel responses to focal ischemia.
Journal of Cerebral Blood Flow and Metabolism, 23, 879–894.
10. Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999). Pathobiology of ischaemic stroke: An
integrated view. Trends in Neurosciences, 22, 391–397.
11. Emerich, D. F., Silva, E., Ali, O., Mooney, D., Bell, W., Yu, S. J., et al. (2010). Injectable VEGF
hydrogels produce near complete neurological and anatomical protection following cerebral
ischemia in rats. Cell Transplantation, 19, 1063–1071.
12. Granger, C. V., Hamilton, B. B., & Fiedler, R. C. (1992). Discharge outcome after stroke rehabilitation. Stroke, 23, 978–982.
13. Greenberg, D. A. (1998). Angiogenesis and stroke. Drug News & Perspectives, 11, 265–270.
14. Greenberg, D. A., & Jin, K. (2007). Regenerating the brain. International Review of
Neurobiology, 77, 1–29.
15. Hayashi, T., Abe, K., & Itoyama, Y. (1998). Reduction of ischemic damage by application of
vascular endothelial growth factor in rat brain after transient ischemia. Journal of Cerebral
Blood Flow and Metabolism, 18, 887–895.
16. Herz, J., Reitmeir, R., Hagen, S. I., Reinboth, B. S., Guo, Z., Zechariah, A., et al. (2012).
Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after
focal cerebral ischemia via mechanisms involving anti-inflammatory actions. Neurobiology of
Disease, 45, 1077–1085.
17. Issa, R., Krupinski, J., Bujny, T., Kumar, S., Kaluza, J., & Kumar, P. (1999). Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke.
Laboratory Investigation, 79, 417–425.
7 Pro-Angiogenic Regenerative Therapies for the Damaged Brain: A Tissue…
inflammation on angiogenesis-induced tissue repair. Taken together, a tissue engineering approach to provascular therapies presents challenges that need to be overcome, before provascular materials are a valuable alternative for the clinical
treatment of brain damage.
References
1. Abe, K., Setoguchi, Y., Hayashi, T., & Itoyama, Y. (1997). Dissociative expression of adenoviralmediated E. coli LacZ gene between ischemic and reperfused rat brains. Neuroscience Letters,
226, 53–56.
2. Allen, C. M. (1984). Predicting the outcome of acute stroke: A prognostic score. Journal of
Neurology, Neurosurgery, and Psychiatry, 47, 475–480.
3. Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., et al. (2016).
Astrocyte scar formation aids central nervous system axon regeneration. Nature, 532,
195–200.
4. Anderson, S. M., Siegman, S. N., & Segura, T. (2011). The effect of vascular endothelial
growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching.
Biomaterials, 32, 7432–7443.
5. Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., et al. (2017).
Heart disease and stroke statistics-2017 update: A report from the American Heart Association.
Circulation, 135, e146–e603.
6. Bible, E., Qutachi, O., Chau, D. Y. S., Alexander, M. R., Shakesheff, K. M., & Modo, M.
(2012). Neo-vascularization of the stroke cavity by implantation of human neural stem cells
on VEGF-releasing PLGA microparticles. Biomaterials, 33, 7435–7346.
7. Castellanos, M., Sobrino, T., & Castillo, J. (2006). Evolving paradigms for neuroprotection:
Molecular identification of ischemic penumbra. Cerebrovascular Diseases, 21(Suppl 2),
71–79.
8. Chopp, M., Li, Y., & Zhang, J. (2008). Plasticity and remodeling of brain. Journal of the
Neurological Sciences, 265, 97–101.
9. del Zoppo, G. J., & Mabuchi, T. (2003). Cerebral microvessel responses to focal ischemia.
Journal of Cerebral Blood Flow and Metabolism, 23, 879–894.
10. Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999). Pathobiology of ischaemic stroke: An
integrated view. Trends in Neurosciences, 22, 391–397.
11. Emerich, D. F., Silva, E., Ali, O., Mooney, D., Bell, W., Yu, S. J., et al. (2010). Injectable VEGF
hydrogels produce near complete neurological and anatomical protection following cerebral
ischemia in rats. Cell Transplantation, 19, 1063–1071.
12. Granger, C. V., Hamilton, B. B., & Fiedler, R. C. (1992). Discharge outcome after stroke rehabilitation. Stroke, 23, 978–982.
13. Greenberg, D. A. (1998). Angiogenesis and stroke. Drug News & Perspectives, 11, 265–270.
14. Greenberg, D. A., & Jin, K. (2007). Regenerating the brain. International Review of
Neurobiology, 77, 1–29.
15. Hayashi, T., Abe, K., & Itoyama, Y. (1998). Reduction of ischemic damage by application of
vascular endothelial growth factor in rat brain after transient ischemia. Journal of Cerebral
Blood Flow and Metabolism, 18, 887–895.
16. Herz, J., Reitmeir, R., Hagen, S. I., Reinboth, B. S., Guo, Z., Zechariah, A., et al. (2012).
Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after
focal cerebral ischemia via mechanisms involving anti-inflammatory actions. Neurobiology of
Disease, 45, 1077–1085.
17. Issa, R., Krupinski, J., Bujny, T., Kumar, S., Kaluza, J., & Kumar, P. (1999). Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke.
Laboratory Investigation, 79, 417–425.
7 Pro-Angiogenic Regenerative Therapies for the Damaged Brain: A Tissue…