186
18. Jin, K., Mao, X. O., & Greenberg, D. A. (2006). Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via rho kinase signaling. Journal of
Neurobiology, 66, 236–242.
19. Ju, R., Wen, Y., Gou, R., Wang, Y., & Xu, Q. (2014). The experimental therapy on brain
ischemia by improvement of local angiogenesis with tissue engineering in the mouse. Cell
Transplantation, 23(Suppl 1), S83–S95.
20. Krupinski, J., Kaluza, J., Kumar, P., Kumar, S., & Wang, J. M. (1994). Role of angiogenesis in
patients with cerebral ischemic stroke. Stroke, 25, 1794–1798.
21. Ma, Y., Zechariah, A., Qu, Y., & Hermann, D. M. (2012). Effects of vascular endothelial
growth factor in ischemic stroke. Journal of Neuroscience Research, 90, 1873–1882.
22. Manoonkitiwongsa, P. S., Jackson-Friedman, C., McMillan, P. J., Schultz, R. L., Lyden, P. D.,
et al. (2001). Angiogenesis after stroke is correlated with increased numbers of macrophages:
The clean-up hypothesis. Journal of Cerebral Blood Flow and Metabolism, 21, 1223–1231.
23. Moshayedi, P., Nih, L. R., Llorente, I. L., Berg, A. R., Cinkornpumin, J., Lowry, W. E., et al.
(2016). Systematic optimization of an engineered hydrogel allows for selective control of
human neural stem cell survival and differentiation after transplantation in the stroke brain.
Biomaterials, 105, 145–155.
24. Nih, L. R., Deroide, N., Leré-Déan, C., Lerouet, D., Soustrat, M., Levy, B. I., et al. (2012).
Neuroblast survival depends on mature vascular network formation after mouse stroke: Role
of endothelial and smooth muscle progenitor cell co-administration. The European Journal of
Neuroscience, 35, 1208–1217.
25. Nih, L. R., Gojgini, S., Carmichael, S. T., & Segura, T. (2018). Dual-function injectable
angiogenic biomaterial for the repair of brain tissue following stroke. Nature Materials, 17,
642–651.
26. Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006). A neurovascular niche for
neurogenesis after stroke. The Journal of Neuroscience, 26, 13007–13016.
27. Oshikawa, M., Okada, K., Kaneko, N., Sawamoto, K., Ajioka, I., et al. (2017). Affinityimmobilization of VEGF on laminin porous sponge enhances angiogenesis in the ischemic
brain. Advanced Healthcare Materials, 6(11), 28488337.
28. Rodriguez-Yanez, M., Castellanos, M., Blanco, M., Mosquera, E., & Castillo, J. (2006).
Vascular protection in brain ischemia. Cerebrovascular Diseases, 21(Suppl 2), 21–29.
29. Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., et al. (2002).
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel
branching morphogenesis. Genes & Development, 16, 2684–2698.
30. Schmidt, R., Schmidt, H., & Fazekas, F. (2000). Vascular risk factors in dementia. Journal of
Neurology, 247, 81–87.
31. Slevin, M., Krupinski, J., Slowik, A., Kumar, P., Szczudlik, A., & Gaffney, J. (2000). Serial
measurement of vascular endothelial growth factor and transforming growth factor-beta1 in
serum of patients with acute ischemic stroke. Stroke, 31, 1863–1870.
32. Slevin, M., Kumar, P., Gaffney, J., Kumar, S., & Krupinski, J. (2006). Can angiogenesis be
exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clinical Science,
111, 171–183.
33. Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., et al. (2003). VEGF-induced
neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. The Journal of
Clinical Investigation, 111, 1843–1851.
34. Szpak, G. M., Lechowicz, W., Lewandowska, E., Bertrand, E., Wierzba-Bobrowicz, T.,
& Dymecki, J. (1999). Border zone neovascularization in cerebral ischemic infarct. Folia
Neuropathologica, 37, 264–268.
35. van Bruggen, N., Thibodeaux, H., Palmer, J. T., Lee, W. P., Fu, L., Cairns, B., et al. (1999).
VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion
injury in the mouse brain. The Journal of Clinical Investigation, 104, 1613–1620.
36. Wang, Y., Kilic, E., Kilic, U., Weber, B., Bassetti, C. L., Marti, H. H., et al. (2005). VEGF
overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal
phenomena. Brain, 128, 52–63.
L. R. Nih et al.
18. Jin, K., Mao, X. O., & Greenberg, D. A. (2006). Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via rho kinase signaling. Journal of
Neurobiology, 66, 236–242.
19. Ju, R., Wen, Y., Gou, R., Wang, Y., & Xu, Q. (2014). The experimental therapy on brain
ischemia by improvement of local angiogenesis with tissue engineering in the mouse. Cell
Transplantation, 23(Suppl 1), S83–S95.
20. Krupinski, J., Kaluza, J., Kumar, P., Kumar, S., & Wang, J. M. (1994). Role of angiogenesis in
patients with cerebral ischemic stroke. Stroke, 25, 1794–1798.
21. Ma, Y., Zechariah, A., Qu, Y., & Hermann, D. M. (2012). Effects of vascular endothelial
growth factor in ischemic stroke. Journal of Neuroscience Research, 90, 1873–1882.
22. Manoonkitiwongsa, P. S., Jackson-Friedman, C., McMillan, P. J., Schultz, R. L., Lyden, P. D.,
et al. (2001). Angiogenesis after stroke is correlated with increased numbers of macrophages:
The clean-up hypothesis. Journal of Cerebral Blood Flow and Metabolism, 21, 1223–1231.
23. Moshayedi, P., Nih, L. R., Llorente, I. L., Berg, A. R., Cinkornpumin, J., Lowry, W. E., et al.
(2016). Systematic optimization of an engineered hydrogel allows for selective control of
human neural stem cell survival and differentiation after transplantation in the stroke brain.
Biomaterials, 105, 145–155.
24. Nih, L. R., Deroide, N., Leré-Déan, C., Lerouet, D., Soustrat, M., Levy, B. I., et al. (2012).
Neuroblast survival depends on mature vascular network formation after mouse stroke: Role
of endothelial and smooth muscle progenitor cell co-administration. The European Journal of
Neuroscience, 35, 1208–1217.
25. Nih, L. R., Gojgini, S., Carmichael, S. T., & Segura, T. (2018). Dual-function injectable
angiogenic biomaterial for the repair of brain tissue following stroke. Nature Materials, 17,
642–651.
26. Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006). A neurovascular niche for
neurogenesis after stroke. The Journal of Neuroscience, 26, 13007–13016.
27. Oshikawa, M., Okada, K., Kaneko, N., Sawamoto, K., Ajioka, I., et al. (2017). Affinityimmobilization of VEGF on laminin porous sponge enhances angiogenesis in the ischemic
brain. Advanced Healthcare Materials, 6(11), 28488337.
28. Rodriguez-Yanez, M., Castellanos, M., Blanco, M., Mosquera, E., & Castillo, J. (2006).
Vascular protection in brain ischemia. Cerebrovascular Diseases, 21(Suppl 2), 21–29.
29. Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., et al. (2002).
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel
branching morphogenesis. Genes & Development, 16, 2684–2698.
30. Schmidt, R., Schmidt, H., & Fazekas, F. (2000). Vascular risk factors in dementia. Journal of
Neurology, 247, 81–87.
31. Slevin, M., Krupinski, J., Slowik, A., Kumar, P., Szczudlik, A., & Gaffney, J. (2000). Serial
measurement of vascular endothelial growth factor and transforming growth factor-beta1 in
serum of patients with acute ischemic stroke. Stroke, 31, 1863–1870.
32. Slevin, M., Kumar, P., Gaffney, J., Kumar, S., & Krupinski, J. (2006). Can angiogenesis be
exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clinical Science,
111, 171–183.
33. Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., et al. (2003). VEGF-induced
neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. The Journal of
Clinical Investigation, 111, 1843–1851.
34. Szpak, G. M., Lechowicz, W., Lewandowska, E., Bertrand, E., Wierzba-Bobrowicz, T.,
& Dymecki, J. (1999). Border zone neovascularization in cerebral ischemic infarct. Folia
Neuropathologica, 37, 264–268.
35. van Bruggen, N., Thibodeaux, H., Palmer, J. T., Lee, W. P., Fu, L., Cairns, B., et al. (1999).
VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion
injury in the mouse brain. The Journal of Clinical Investigation, 104, 1613–1620.
36. Wang, Y., Kilic, E., Kilic, U., Weber, B., Bassetti, C. L., Marti, H. H., et al. (2005). VEGF
overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal
phenomena. Brain, 128, 52–63.
L. R. Nih et al.