31. Lee S, Song KM, Jeon W, Jo H, Shim YB, Ban C (2012) A highly sensitive aptasensor towards
plasmodium lactate dehydrogenase for the diagnosis of malaria. Biosens Bioelectron 35
(1):291–296. https://doi.org/10.1016/j.bios.2012.03.003
32. Figueroa-Miranda G, Feng L, Shiu SC-C, Dirkzwager RM, Cheung Y-W, Tanner JA,
Schöning MJ, Offenhäusser A, Mayer D (2018) Aptamer-based electrochemical biosensor
for highly sensitive and selective malaria detection with adjustable dynamic response range
and reusability. Sensors Actuators B Chem 255:235–243. https://doi.org/10.1016/j.snb.2017.
07.117
33. Kiilerich-Pedersen K, Daprà J, Cherré S, Rozlosnik N (2013) High sensitivity point-of-care
device for direct virus diagnostics. Biosens Bioelectron 49:374–379. https://doi.org/10.1016/j.
bios.2013.05.046
34. Otero C, Penaloza JP, Rodas PI, Fernandez-Ramires R, Velasquez L, Jung JE (2014) Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases. Fundam Clin Pharmacol 28(6):593–607. https://doi.org/10.1111/fcp.12080
35. Zhao F, Xie Q, Xu M, Wang S, Zhou J, Liu F (2015) RNA aptamer based electrochemical
biosensor for sensitive and selective detection of cAMP. Biosens Bioelectron 66:238–243.
https://doi.org/10.1016/j.bios.2014.11.024
36. Wang Y, Feng J, Tan Z, Wang H (2014) Electrochemical impedance spectroscopy aptasensor
for ultrasensitive detection of adenosine with dual backfillers. Biosens Bioelectron
60:218–223. https://doi.org/10.1016/j.bios.2014.04.022
37. Feng L, Chen Y, Ren J, Qu X (2011) A graphene functionalized electrochemical aptasensor for
selective label-free detection of cancer cells. Biomaterials 32(11):2930–2937. https://doi.org/
10.1016/j.biomaterials.2011.01.002
38. Kashefi-Kheyrabadi L, Mehrgardi MA, Wiechec E, Turner AP, Tiwari A (2014) Ultrasensitive
detection of human liver hepatocellular carcinoma cells using a label-free aptasensor. Anal
Chem 86(10):4956–4960. https://doi.org/10.1021/ac500375p
39. Hashkavayi AB, Raoof JB, Ojani R, Kavoosian S (2017) Ultrasensitive electrochemical
aptasensor based on sandwich architecture for selective label-free detection of colorectal
cancer (CT26) cells. Biosens Bioelectron 92:630–637. https://doi.org/10.1016/j.bios.2016.
10.042
40. Shen H, Yang J, Chen Z, Chen X, Wang L, Hu J, Ji F, Xie G, Feng W (2016) A novel labelfree and reusable electrochemical cytosensor for highly sensitive detection and specific
collection of CTCs. Biosens Bioelectron 81:495–502. https://doi.org/10.1016/j.bios.2016.03.
048
41. Tsuchiya N, Sawada Y, Endo I, Saito K, Uemura Y, Nakatsura T (2015) Biomarkers for the
early diagnosis of hepatocellular carcinoma. World J Gastroenterol 21(37):10573–10583.
https://doi.org/10.3748/wjg.v21.i37.10573
42. Laboria N, Fragoso A, Kemmner W, Latta D, Nilsson O, Botero ML, Drese K, O’Sullivan CK
(2010) Amperometric immunosensor for carcinoembryonic antigen in colon cancer samples
based on monolayers of dendritic bipodal scaffolds. Anal Chem 82(5):1712–1719. https://doi.
org/10.1021/ac902162e
43. Shekari Z, Zare HR, Falahati A (2017) Developing an impedimetric aptasensor for selective
label–free detection of CEA as a cancer biomarker based on gold nanoparticles loaded in
functionalized mesoporous silica films. J Electrochem Soc 164(13):B739–B745. https://doi.
org/10.1149/2.1991713jes
44. Wang W, Ge L, Sun X, Hou T, Li F (2015) Graphene-assisted label-free homogeneous
electrochemical biosensing strategy based on aptamer-switched bidirectional DNA polymerization. ACS Appl Mater Interfaces 7(51):28566–28575. https://doi.org/10.1021/acsami.
5b09932
45. Guo C, Su F, Song Y, Hu B, Wang M, He L, Peng D, Zhang Z (2017) Aptamer-templated
silver nanoclusters embedded in zirconium metal-organic framework for bifunctional electrochemical and SPR aptasensors toward carcinoembryonic antigen. ACS Appl Mater Interfaces
9(47):41188–41199. https://doi.org/10.1021/acsami.7b14952
Impedimetric Aptamer-Based Biosensors: Applications
83
plasmodium lactate dehydrogenase for the diagnosis of malaria. Biosens Bioelectron 35
(1):291–296. https://doi.org/10.1016/j.bios.2012.03.003
32. Figueroa-Miranda G, Feng L, Shiu SC-C, Dirkzwager RM, Cheung Y-W, Tanner JA,
Schöning MJ, Offenhäusser A, Mayer D (2018) Aptamer-based electrochemical biosensor
for highly sensitive and selective malaria detection with adjustable dynamic response range
and reusability. Sensors Actuators B Chem 255:235–243. https://doi.org/10.1016/j.snb.2017.
07.117
33. Kiilerich-Pedersen K, Daprà J, Cherré S, Rozlosnik N (2013) High sensitivity point-of-care
device for direct virus diagnostics. Biosens Bioelectron 49:374–379. https://doi.org/10.1016/j.
bios.2013.05.046
34. Otero C, Penaloza JP, Rodas PI, Fernandez-Ramires R, Velasquez L, Jung JE (2014) Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases. Fundam Clin Pharmacol 28(6):593–607. https://doi.org/10.1111/fcp.12080
35. Zhao F, Xie Q, Xu M, Wang S, Zhou J, Liu F (2015) RNA aptamer based electrochemical
biosensor for sensitive and selective detection of cAMP. Biosens Bioelectron 66:238–243.
https://doi.org/10.1016/j.bios.2014.11.024
36. Wang Y, Feng J, Tan Z, Wang H (2014) Electrochemical impedance spectroscopy aptasensor
for ultrasensitive detection of adenosine with dual backfillers. Biosens Bioelectron
60:218–223. https://doi.org/10.1016/j.bios.2014.04.022
37. Feng L, Chen Y, Ren J, Qu X (2011) A graphene functionalized electrochemical aptasensor for
selective label-free detection of cancer cells. Biomaterials 32(11):2930–2937. https://doi.org/
10.1016/j.biomaterials.2011.01.002
38. Kashefi-Kheyrabadi L, Mehrgardi MA, Wiechec E, Turner AP, Tiwari A (2014) Ultrasensitive
detection of human liver hepatocellular carcinoma cells using a label-free aptasensor. Anal
Chem 86(10):4956–4960. https://doi.org/10.1021/ac500375p
39. Hashkavayi AB, Raoof JB, Ojani R, Kavoosian S (2017) Ultrasensitive electrochemical
aptasensor based on sandwich architecture for selective label-free detection of colorectal
cancer (CT26) cells. Biosens Bioelectron 92:630–637. https://doi.org/10.1016/j.bios.2016.
10.042
40. Shen H, Yang J, Chen Z, Chen X, Wang L, Hu J, Ji F, Xie G, Feng W (2016) A novel labelfree and reusable electrochemical cytosensor for highly sensitive detection and specific
collection of CTCs. Biosens Bioelectron 81:495–502. https://doi.org/10.1016/j.bios.2016.03.
048
41. Tsuchiya N, Sawada Y, Endo I, Saito K, Uemura Y, Nakatsura T (2015) Biomarkers for the
early diagnosis of hepatocellular carcinoma. World J Gastroenterol 21(37):10573–10583.
https://doi.org/10.3748/wjg.v21.i37.10573
42. Laboria N, Fragoso A, Kemmner W, Latta D, Nilsson O, Botero ML, Drese K, O’Sullivan CK
(2010) Amperometric immunosensor for carcinoembryonic antigen in colon cancer samples
based on monolayers of dendritic bipodal scaffolds. Anal Chem 82(5):1712–1719. https://doi.
org/10.1021/ac902162e
43. Shekari Z, Zare HR, Falahati A (2017) Developing an impedimetric aptasensor for selective
label–free detection of CEA as a cancer biomarker based on gold nanoparticles loaded in
functionalized mesoporous silica films. J Electrochem Soc 164(13):B739–B745. https://doi.
org/10.1149/2.1991713jes
44. Wang W, Ge L, Sun X, Hou T, Li F (2015) Graphene-assisted label-free homogeneous
electrochemical biosensing strategy based on aptamer-switched bidirectional DNA polymerization. ACS Appl Mater Interfaces 7(51):28566–28575. https://doi.org/10.1021/acsami.
5b09932
45. Guo C, Su F, Song Y, Hu B, Wang M, He L, Peng D, Zhang Z (2017) Aptamer-templated
silver nanoclusters embedded in zirconium metal-organic framework for bifunctional electrochemical and SPR aptasensors toward carcinoembryonic antigen. ACS Appl Mater Interfaces
9(47):41188–41199. https://doi.org/10.1021/acsami.7b14952
Impedimetric Aptamer-Based Biosensors: Applications
83