Index
A
Adenovirus, 196
Affinity
biophysical binding parameters, 2
constant, 11–13
equilibrium-binding, 8
steady-state, 6
Affinity chromatography
advent, 98–108
aptamer-and antibody-based, 126–129
aptamer grafting methods, 112–116
biological samples, 125
blood proteins, 117–122
DNA-related proteins, 122
enantiomers, 125
field, 108–110
group-specific proteins, 122–124
milestones, 95–97
RNA vs. DNA aptamer ligands, 111–112
single-step purification, 124
subject focus, 94–95
TTF1, 124
Anthracycline, 63
Antibiotics, 27, 47, 62, 63, 125
Aptamer
comparison, 32–36
detection strategies, 22–32
gold nanoparticles (see Aptamer-modified
gold nanoparticles)
hydrolysis, 125–126
sanitization, 125–126
target interactions
binding parameters, 2–3
biophysical techniques, 3–11
Aptamer-modified gold nanoparticles
colorimetric assays, 166, 168–169
LFAs, 165–167
therapeutic applications, 184–187
Aptamer-modified nanoparticles
AuNPs, 172–175
cell detection, 171
dendrimers, 179, 181
drug delivery, 172–181
electrochemical sensors, 170
fluorescence biosensors, 169–170
liposomes, 175–177
micelles, 175–177
MSNs, 178–180
polymer nanoparticles, 177–178
PTT and photodynamic therapy, 181–184
therapeutic applications, 171–172
virus capsids, 181
Aptamers-based diagnostics
in vitro applications, 146–148
in vivo aptamer, 148–149
probe design, 144–146
Aptasensor
bacteria and toxins, 65
benefits and challenges, 78–81
drug residues, 63
faradaic impedimetric, 22–28
food control
ELISAs, 68
microorganisms, 73–77
mycotoxins, 69–73
health care applications (see Health care)
impedimetric measurement techniques,
20–22
influenza virus, 147
non-faradaic systems, 28–32
211
A
Adenovirus, 196
Affinity
biophysical binding parameters, 2
constant, 11–13
equilibrium-binding, 8
steady-state, 6
Affinity chromatography
advent, 98–108
aptamer-and antibody-based, 126–129
aptamer grafting methods, 112–116
biological samples, 125
blood proteins, 117–122
DNA-related proteins, 122
enantiomers, 125
field, 108–110
group-specific proteins, 122–124
milestones, 95–97
RNA vs. DNA aptamer ligands, 111–112
single-step purification, 124
subject focus, 94–95
TTF1, 124
Anthracycline, 63
Antibiotics, 27, 47, 62, 63, 125
Aptamer
comparison, 32–36
detection strategies, 22–32
gold nanoparticles (see Aptamer-modified
gold nanoparticles)
hydrolysis, 125–126
sanitization, 125–126
target interactions
binding parameters, 2–3
biophysical techniques, 3–11
Aptamer-modified gold nanoparticles
colorimetric assays, 166, 168–169
LFAs, 165–167
therapeutic applications, 184–187
Aptamer-modified nanoparticles
AuNPs, 172–175
cell detection, 171
dendrimers, 179, 181
drug delivery, 172–181
electrochemical sensors, 170
fluorescence biosensors, 169–170
liposomes, 175–177
micelles, 175–177
MSNs, 178–180
polymer nanoparticles, 177–178
PTT and photodynamic therapy, 181–184
therapeutic applications, 171–172
virus capsids, 181
Aptamers-based diagnostics
in vitro applications, 146–148
in vivo aptamer, 148–149
probe design, 144–146
Aptasensor
bacteria and toxins, 65
benefits and challenges, 78–81
drug residues, 63
faradaic impedimetric, 22–28
food control
ELISAs, 68
microorganisms, 73–77
mycotoxins, 69–73
health care applications (see Health care)
impedimetric measurement techniques,
20–22
influenza virus, 147
non-faradaic systems, 28–32
211