27. Bruno JG, Carrillo MP, Phillips T, Edge A (2011) Discrimination of recombinant from natural
human growth hormone using DNA aptamers. J Biomol Tech 22(1):27–36
28. Kalra P, Dhiman A, Cho WC, Bruno JG, Sharma TK (2018) Simple methods and rational
design for enhancing aptamer sensitivity and specificity. Front Mol Biosci 5:1–16. https://doi.
org/10.3389/fmolb.2018.00041
29. Bruno JG, Kiel JL (2002) Use of magnetic beads in selection and detection of biotoxin aptamers
by electrochemiluminescence and enzymatic methods. Biotechniques 32(1):178–183. https://
doi.org/10.2144/02321dd04
30. Bruno JG, Phillips T, Montez T (2015) Preliminary development of DNA aptamers to inhibit
phospholipase A2 activity of bee and cobra venoms. J Bionanosci 9(4):270–275. https://doi.org/
10.1166/jbns.2015.1301
31. Bruno JG, Richarte AM, Carrillo MP, Edge A (2012) An aptamer beacon responsive
to botulinum toxins. Biosens Bioelectron 31(1):240–243. https://doi.org/10.1016/j.bios.2011.
10.024
32. Zhao L, Huang Y, Dong Y, Han X, Wang S, Liang X (2018) Aptamers and aptasensors for
highly specific recognition and sensitive detection of marine biotoxins: recent advances and
perspectives. Toxins 10(11):E427. https://doi.org/10.3390/toxins10110427
33. Bruno JG, Phillips T, Carrillo MP, Crowell R (2009) Plastic-adherent DNA aptamer-magnetic
bead and quantum dot sandwich assay for Campylobacter detection. J Fluoresc 19(3):427–435.
https://doi.org/10.1007/s10895-008-0429-8
34. Bruno JG, Sivils JC (2017) Further characterization and independent validation of a DNA
aptamer-quantum dot-based magnetic sandwich assay for Campylobacter. Folia Microbiol 62
(6):485–490. https://doi.org/10.1007/s12223-017-0520-0
35. Bruno JG (2017) Long shelf life of a lyophilized DNA aptamer beacon assay. J Fluoresc 27
(2):439–441. https://doi.org/10.1007/s10895-016-2014-x
Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics
209
human growth hormone using DNA aptamers. J Biomol Tech 22(1):27–36
28. Kalra P, Dhiman A, Cho WC, Bruno JG, Sharma TK (2018) Simple methods and rational
design for enhancing aptamer sensitivity and specificity. Front Mol Biosci 5:1–16. https://doi.
org/10.3389/fmolb.2018.00041
29. Bruno JG, Kiel JL (2002) Use of magnetic beads in selection and detection of biotoxin aptamers
by electrochemiluminescence and enzymatic methods. Biotechniques 32(1):178–183. https://
doi.org/10.2144/02321dd04
30. Bruno JG, Phillips T, Montez T (2015) Preliminary development of DNA aptamers to inhibit
phospholipase A2 activity of bee and cobra venoms. J Bionanosci 9(4):270–275. https://doi.org/
10.1166/jbns.2015.1301
31. Bruno JG, Richarte AM, Carrillo MP, Edge A (2012) An aptamer beacon responsive
to botulinum toxins. Biosens Bioelectron 31(1):240–243. https://doi.org/10.1016/j.bios.2011.
10.024
32. Zhao L, Huang Y, Dong Y, Han X, Wang S, Liang X (2018) Aptamers and aptasensors for
highly specific recognition and sensitive detection of marine biotoxins: recent advances and
perspectives. Toxins 10(11):E427. https://doi.org/10.3390/toxins10110427
33. Bruno JG, Phillips T, Carrillo MP, Crowell R (2009) Plastic-adherent DNA aptamer-magnetic
bead and quantum dot sandwich assay for Campylobacter detection. J Fluoresc 19(3):427–435.
https://doi.org/10.1007/s10895-008-0429-8
34. Bruno JG, Sivils JC (2017) Further characterization and independent validation of a DNA
aptamer-quantum dot-based magnetic sandwich assay for Campylobacter. Folia Microbiol 62
(6):485–490. https://doi.org/10.1007/s12223-017-0520-0
35. Bruno JG (2017) Long shelf life of a lyophilized DNA aptamer beacon assay. J Fluoresc 27
(2):439–441. https://doi.org/10.1007/s10895-016-2014-x
Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics
209