9 Natural Selection, Genetic Variation, and Human Diversity
217
Kimura et al. (2007)
1 M SNPs
LD (rMHH)
3 HapMap I
17 regions
DARC
SLC24A5
MATP
EDAR
Kimura et al. (2008)
500 K SNPs
LD (AREHH, rHH)
Melanesian, Polynesian
IGF1R
Lappalainen et al.
(2010)
250 K or 500 K SNPs
LD (iHS, rEHH) and
population differentiation
(FST)
Finnish, Swedish,
German,
British—100–350 each;
HapMap reference pops
60 regions
APOE
López Herráez et al.
(2009)
900 K SNPs
LD (ln[Rsb])
HGDP (5 ea. Of 51 pops)
100 per world
region considered
632 from all pops
SLC24A5
LCT
TRPV5
TRPV6
EDAR
Nielsen et al. (2009)
13,400 genes
(sequence)
Site Frequency Spectrum
(G2D, MWu-high,
MWu-low)
Pop diff (FST)
European Americans
African Americans
15 regions
SLC45A2
Nielsen et al. (2005)
HapMap II Chr. 2 and
148 genes from Seattle
SNPs resequencing
Site frequency Spectrum
(CLR, MWu)
SeattleSNPs – Europeans
and Afr. Amer.
3 HapMap II
LCT
O’Reilly et al. (2008)
1.6 M or 1 M SNPs
LD (Ped/pop)
HapMap, Perlegen
4 regions
CCR5
Oleksyk et al. (2008)
200 K SNPs
Population differentiation
(S 2
F
ST )
SFS (heterozygosity)
European-American,
African-American
180 regions
FOXP2
CCR5
(continued)