192
quorum sensing system might be a promising insight to prevent the virulent behavior of bacteria (Bzdrenga et al. 2017a).
With each passing year, antibiotic resistance is emerging as a major public health
concern which necessitates the need for novel therapeutic approaches to be developed. There is a multifaceted association between antibiotic resistance and quorum
sensing. Quorum quenching/ inhibition of pathogenic microbes is also called anti
Table 8.1 (continued)
Inhibitors
Target
Category
Species
Reference
Iberin
LasR and RhlR
Plant:
Horseradish
Armoracia
rusticana
Jakobsen
et al.
(2012a)
Malabaricone C
CviR
Plant:
Myristicaceae
Myristica
cinnamomea
Chong et al.
(2011)
A drimane
sesquiterpene
C. violaceum
Plant: Tree
Drimys winteri
Paza et al.
(2013)
Curcumin
CviR
Plant:
Turmeric
Curcuma longa
Packiavathy
et al. (2014)
2,5-di-O-galloyl-D
hamamelose
RNAIII
Plant: Witch
hazel
Hamamelis
virginiana
Kiran et al.
(2008)
p-Coumaric acid
PpuR, CviR and TraR Plants
Various plants
Bodini et al.
(2009)
Ellagitannins and
urolithins
P. aeruginosa and
Yersinia enterocolitica
Plants and
bacteria
Conocarpus
erectus
Adonizio
et al. (2008)
and
GiménezBastida et al.
(2012)
Floridoside,
betonicine and
isethionic acid
TraR
Red algae
Ahnfeltiopsis
flabelliformes
Liu et al.
(2008)
Exudates
LuxR
Roundworm
Caenorhabditis
elegans
Kaplan et al.
(2009)
Lumichrome
Sinorhizobiummeliloti Soilfreshwater
alga
Chlamydomonas
reinhardtii
Teplitski
et al. (2004)
and
Rajamani
et al. (2008)
Manoalide,
manoalide
monoacetate, and
secomanoalide
LuxR and LasR
Sponge
Luffareilla
variabilis
Skindersoe
et al. (2008)
Alkaloid
(hymenialdisin)
LuxR and LasR
Sponge
Hymeniacidon
aldis
Dobretsov
et al. (2010)
Emodin
P. aeruginosa and S.
maltophilia
TCMs
Rhubarb
Ding et al.
(2011)
Flavonoid
(baicalein)
TraR and RhlR
TCMs
Scutellaria
baicalensis
Zeng et al.
(2008)
S. Kumar et al.