Kerhornou A, Nie X, Hall N, Anjard C,
Hemphill L, Bason N, Farbrother P,
Desany B, Just E, Morio T, Rost R,
Churcher C, Cooper J, Haydock S,
Driessche N, Cronin A, Goodhead I,
Muzny D, Mourier T, Pain A, Lu M,
Harper D, Lindsay R, Hauser H, James K,
Quiles M, Babu MM, Saito T, Buchrieser C,
Wardroper A, Felder M, Thangavelu M,
Johnson D, Knights A, Loulseged H,
Mungall K, Oliver K, Price C, Quail MA,
Urushihara
H,
Hernandez
J,
Rabbinowitsch E, Steffen D, Sanders M,
Ma J, Kohara Y, Sharp S, Simmonds M,
Spiegler S, Tivey A, Sugano S, White B,
Walker D, Woodward J, Winckler T,
Tanaka Y, Shaulsky G, Schleicher M,
Weinstock G, Rosenthal A, Cox EC, Chisholm
RL, Gibbs R, Loomis WF, Platzer M, Kay RR,
Williams J, Dear PH, Noegel AA, Barrell B,
Kuspa A (2005) The genome of the social
amoeba Dictyostelium discoideum. Nature 435
(7038):43–57.
https://doi.org/10.1038/
nature03481
4. Iriki H, Kawata T, Muramoto T (2019) Generation of deletions and precise point mutations
in Dictyostelium discoideum using the
CRISPR nickase. PLoS One 14(10):
e0224128. https://doi.org/10.1371/journal.
pone.0224128
5. Sekine R, Kawata T, Muramoto T (2018)
CRISPR/Cas9 mediated targeting of multiple
genes in Dictyostelium. Sci Rep 8(1):1–11.
https://doi.org/10.1038/s41598-01826756-z
6. Phillips JE, Huang E, Shaulsky G, Gomer RH
(2011) The putative bZIP transcripton factor
BzpN slows proliferation and functions in the
regulation of cell density by autocrine signals in
Dictyostelium. PLoS One 6(7). https://doi.
org/10.1371/journal.pone.0021765
7. Stinear TP, Seemann T, Harrison PF, Jenkin
GA, Davies JK, Johnson PD, Abdellah Z,
Arrowsmith C, Chillingworth T, Churcher C,
Clarke K, Cronin A, Davis P, Goodhead I,
Holroyd N, Jagels K, Lord A, Moule S,
Mungall K, Norbertczak H, Quail MA,
Rabbinowitsch E, Walker D, White B,
Whitehead S, Small PL, Brosch R,
Ramakrishnan L, Fischbach MA, Parkhill J,
Cole ST (2008) Insights from the complete
genome sequence of Mycobacterium marinum
on the evolution of Mycobacterium tuberculosis. Genome Res 18(5):729–741. https://doi.
org/10.1101/gr.075069.107
8. Cambier CJ, Falkow S, Ramakrishnan L
(2014) Host evasion and exploitation schemes
of Mycobacterium tuberculosis. Cell 159
(7):1497–1509. https://doi.org/10.1016/j.
cell.2014.11.024
9. Tobin DM, Ramakrishnan L (2008) Comparative pathogenesis of Mycobacterium marinum
and Mycobacterium tuberculosis. Cell Microbiol 10(5):1027–1039. https://doi.org/10.
1111/j.1462-5822.2008.01133.x
10. Cardenal-Mun ˜oz E, Barisch C, Lefranc ¸ois LH,
Lo ´ pez-Jime ´nez AT, Soldati T (2018) When
Dicty Met Myco, a (not so) romantic story
about one amoeba and its intracellular pathogen. Front Cell Infect Microbiol 7. https://
doi.org/10.3389/fcimb.2017.00529
11. Russell DG (2007) Who puts the tubercle in
tuberculosis? Nat Rev Microbiol 5(1):39–47.
https://doi.org/10.1038/nrmicro1538
12. Sturgill-Koszycki
S,
Schlesinger
PH,
Chakraborty P, Haddix PL, Collins HL, Fok
AK, Allen RD, Gluck SL, Heuser J, Russell DG
(1994) Lack of acidification in Mycobacterium
phagosomes produced by exclusion of the
vesicular
proton-ATPase.
Science
263
(5147):678–681. https://doi.org/10.1126/
science.8303277
13. Wong D, Bach H, Sun J, Hmama Z, Av-Gay Y
(2011) Mycobacterium tuberculosis protein
tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification. Proc Natl Acad Sci U S A 108
(48):19371–19376.
https://doi.org/10.
1073/pnas.1109201108
14. Dhar N, McKinney J, Manina G (2016) Phenotypic heterogeneity in Mycobacterium
tuberculosis. Microbiol Spectr 4(6). https://
doi.org/10.1128/microbiolspec.TBTB20021-2016
15. Dhar N, McKinney JD (2007) Microbial phenotypic heterogeneity and antibiotic tolerance.
Curr Opin Microbiol 10(1):30–38. https://
doi.org/10.1016/j.mib.2006.12.007
16. Delince ´ MJ, Bureau J-B, Lo ´ pez-Jime ´nez AT,
Cosson P, Soldati T, McKinney JD (2016) A
microfluidic cell-trapping device for single-cell
tracking of host–microbe interactions. Lab
Chip 16(17):3276–3285. https://doi.org/
10.1039/C6LC00649C
17. Lo ´ pez-Jime ´nez AT, Hagedorn M, Delince ´ MJ,
McKinney J, Soldati T (2019) The developmental cycle of Dictyostelium discoideum
ensures curing of a mycobacterial infection at
both cell-autonomous level and by collaborative exclusion. bioRxiv:586263. https://doi.
org/10.1101/586263
18. Trofimov V, Kicka S, Mucaria S, Hanna N,
Ramon-Olayo F, Del Peral LV-G, Lelie `vre J,
Ballell L, Scapozza L, Besra GS, Cox JAG,
Soldati T (2018) Antimycobacterial drug
202
Manon Mottet et al.
Hemphill L, Bason N, Farbrother P,
Desany B, Just E, Morio T, Rost R,
Churcher C, Cooper J, Haydock S,
Driessche N, Cronin A, Goodhead I,
Muzny D, Mourier T, Pain A, Lu M,
Harper D, Lindsay R, Hauser H, James K,
Quiles M, Babu MM, Saito T, Buchrieser C,
Wardroper A, Felder M, Thangavelu M,
Johnson D, Knights A, Loulseged H,
Mungall K, Oliver K, Price C, Quail MA,
Urushihara
H,
Hernandez
J,
Rabbinowitsch E, Steffen D, Sanders M,
Ma J, Kohara Y, Sharp S, Simmonds M,
Spiegler S, Tivey A, Sugano S, White B,
Walker D, Woodward J, Winckler T,
Tanaka Y, Shaulsky G, Schleicher M,
Weinstock G, Rosenthal A, Cox EC, Chisholm
RL, Gibbs R, Loomis WF, Platzer M, Kay RR,
Williams J, Dear PH, Noegel AA, Barrell B,
Kuspa A (2005) The genome of the social
amoeba Dictyostelium discoideum. Nature 435
(7038):43–57.
https://doi.org/10.1038/
nature03481
4. Iriki H, Kawata T, Muramoto T (2019) Generation of deletions and precise point mutations
in Dictyostelium discoideum using the
CRISPR nickase. PLoS One 14(10):
e0224128. https://doi.org/10.1371/journal.
pone.0224128
5. Sekine R, Kawata T, Muramoto T (2018)
CRISPR/Cas9 mediated targeting of multiple
genes in Dictyostelium. Sci Rep 8(1):1–11.
https://doi.org/10.1038/s41598-01826756-z
6. Phillips JE, Huang E, Shaulsky G, Gomer RH
(2011) The putative bZIP transcripton factor
BzpN slows proliferation and functions in the
regulation of cell density by autocrine signals in
Dictyostelium. PLoS One 6(7). https://doi.
org/10.1371/journal.pone.0021765
7. Stinear TP, Seemann T, Harrison PF, Jenkin
GA, Davies JK, Johnson PD, Abdellah Z,
Arrowsmith C, Chillingworth T, Churcher C,
Clarke K, Cronin A, Davis P, Goodhead I,
Holroyd N, Jagels K, Lord A, Moule S,
Mungall K, Norbertczak H, Quail MA,
Rabbinowitsch E, Walker D, White B,
Whitehead S, Small PL, Brosch R,
Ramakrishnan L, Fischbach MA, Parkhill J,
Cole ST (2008) Insights from the complete
genome sequence of Mycobacterium marinum
on the evolution of Mycobacterium tuberculosis. Genome Res 18(5):729–741. https://doi.
org/10.1101/gr.075069.107
8. Cambier CJ, Falkow S, Ramakrishnan L
(2014) Host evasion and exploitation schemes
of Mycobacterium tuberculosis. Cell 159
(7):1497–1509. https://doi.org/10.1016/j.
cell.2014.11.024
9. Tobin DM, Ramakrishnan L (2008) Comparative pathogenesis of Mycobacterium marinum
and Mycobacterium tuberculosis. Cell Microbiol 10(5):1027–1039. https://doi.org/10.
1111/j.1462-5822.2008.01133.x
10. Cardenal-Mun ˜oz E, Barisch C, Lefranc ¸ois LH,
Lo ´ pez-Jime ´nez AT, Soldati T (2018) When
Dicty Met Myco, a (not so) romantic story
about one amoeba and its intracellular pathogen. Front Cell Infect Microbiol 7. https://
doi.org/10.3389/fcimb.2017.00529
11. Russell DG (2007) Who puts the tubercle in
tuberculosis? Nat Rev Microbiol 5(1):39–47.
https://doi.org/10.1038/nrmicro1538
12. Sturgill-Koszycki
S,
Schlesinger
PH,
Chakraborty P, Haddix PL, Collins HL, Fok
AK, Allen RD, Gluck SL, Heuser J, Russell DG
(1994) Lack of acidification in Mycobacterium
phagosomes produced by exclusion of the
vesicular
proton-ATPase.
Science
263
(5147):678–681. https://doi.org/10.1126/
science.8303277
13. Wong D, Bach H, Sun J, Hmama Z, Av-Gay Y
(2011) Mycobacterium tuberculosis protein
tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification. Proc Natl Acad Sci U S A 108
(48):19371–19376.
https://doi.org/10.
1073/pnas.1109201108
14. Dhar N, McKinney J, Manina G (2016) Phenotypic heterogeneity in Mycobacterium
tuberculosis. Microbiol Spectr 4(6). https://
doi.org/10.1128/microbiolspec.TBTB20021-2016
15. Dhar N, McKinney JD (2007) Microbial phenotypic heterogeneity and antibiotic tolerance.
Curr Opin Microbiol 10(1):30–38. https://
doi.org/10.1016/j.mib.2006.12.007
16. Delince ´ MJ, Bureau J-B, Lo ´ pez-Jime ´nez AT,
Cosson P, Soldati T, McKinney JD (2016) A
microfluidic cell-trapping device for single-cell
tracking of host–microbe interactions. Lab
Chip 16(17):3276–3285. https://doi.org/
10.1039/C6LC00649C
17. Lo ´ pez-Jime ´nez AT, Hagedorn M, Delince ´ MJ,
McKinney J, Soldati T (2019) The developmental cycle of Dictyostelium discoideum
ensures curing of a mycobacterial infection at
both cell-autonomous level and by collaborative exclusion. bioRxiv:586263. https://doi.
org/10.1101/586263
18. Trofimov V, Kicka S, Mucaria S, Hanna N,
Ramon-Olayo F, Del Peral LV-G, Lelie `vre J,
Ballell L, Scapozza L, Besra GS, Cox JAG,
Soldati T (2018) Antimycobacterial drug
202
Manon Mottet et al.