121
Notch Signaling in Early Embryogenesis
variability of expression profles of homeologous genes for
Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus
laevis. Dev. Biol. 426, 270–290. https://doi.org/10.1016/j.
ydbio.2016.12.006
Milet, C., Maczkowiak, F., Roche, D.D., Monsoro-Burq, A.H.,
2013. Pax3 and Zic1 drive induction and differentiation
of multipotent, migratory, and functional neural crest in
Xenopus embryos. Proc. Natl. Acad. Sci. U. S. A. 110, 5528–
5533. https://doi.org/10.1073/pnas.1219124110
Minsuk, S.B., Keller, R.E., 1997. Surface mesoderm in Xenopus:
A revision of the stage 10 fate map. Dev. Genes Evol. 207,
389–401. https://doi.org/10.1007/s004270050128
Mir, A., Kofron, M., Heasman, J., Mogle, M., Lang, S., Birsoy, B.,
Wylie, C., 2008. Long- and short-range signals control the
dynamic expression of an animal hemisphere-specifc gene in
Xenopus. Dev. Biol. 315, 161–172. https://doi.org/10.1016/j.
ydbio.2007.12.022
Mohr, O.L., 1919. Character changes caused by mutation of an
entire region of a chromosome in Drosophila. Genetics 4,
275–282.
Moody, S.A., 1987a. Fates of the blastomeres of the 16-cell stage
Xenopus embryo. Dev. Biol. 119, 560–578. https://doi.
org/10.1016/0012-1606(87)90059-5
Moody, S.A., 1987b. Fates of the blastomeres of the 32-cell-stage
Xenopus embryo. Dev. Biol. 122, 300–319. https://doi.
org/10.1016/0012-1606(87)90296-x
Moreno, T.A., Kintner, C., 2004. Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis. Dev. Cell 6, 205–218. https://doi.org/10.1016/
S1534-5807(04)00026-7
Morgan, T.H., 1917. The theory of the gene. Am. Nat. 51, 513–544.
https://doi.org/10.1086/279629
Muñoz-Descalzo, S., Sanders, P.G.T., Montagne, C., Johnson, R.I.,
Balayo, T., Martinez Arias, A., 2010. Wingless modulates
the ligand independent traffc of Notch through Dishevelled.
Fly (Austin). 4, 182–193. https://doi.org/10.4161/fly.4.3.
11998
Murai, K., Philpott, A., Jones, P.H., 2011. Hes6 is required for the
neurogenic activity of neurogenin and NeuroD. PLoS One 6,
e27880. https://doi.org/10.1371/journal.pone.0027880
Murai, K., Vernon, A.E., Philpott, A., Jones, P., 2007. Hes6 is
required for MyoD induction during gastrulation. Dev. Biol.
312, 61–76. https://doi.org/10.1016/j.ydbio.2007.09.011
Murato, Y., Hashimoto, C., 2009. Xhairy2 functions in Xenopus
lens development by regulating p27(xic1) expression. Dev.
Dyn. 238, 2179–2192. https://doi.org/10.1002/dvdy.21883
Murato, Y., Nagatomo, K., Yamaguti, M., Hashimoto, C., 2007.
Two alloalleles of Xenopus laevis hairy2 gene: Evolution
of duplicated gene function from a developmental perspective. Dev. Genes Evol. 217, 665–673. https://doi.org/10.1007/
s00427-007-0176-x
Murato, Y., Yamaguti, M., Katamura, M., Cho, K.W.Y., Hashimoto,
C., 2006. Two modes of action by which Xenopus hairy2b
establishes tissue demarcation in the Spemann-Mangold
organizer. Int. J. Dev. Biol. 50, 463–471. https://doi.org/
10.1387/ijdb.052106ym
Murgan, S., Castro Colabianchi, A.M., Monti, R.J., Boyadjián
López, L.E., Aguirre, C.E., Stivala, E.G., Carrasco, A.E.,
López, S.L., 2014. FoxA4 favours notochord formation by
inhibiting contiguous mesodermal fates and restricts anterior neural development in Xenopus embryos. PLoS One 9,
e110559. https://doi.org/10.1371/journal.pone.0110559
Nagano, T., Takehara, S., Takahashi, M., Aizawa, S., Yamamoto,
A., 2006. Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos.
Development 133, 4643–4654. https://doi.org/10.1242/
dev.02657
Nagatomo, K., Hashimoto, C., 2007. Xenopus hairy2 functions in
neural crest formation by maintaining cells in a mitotic and
undifferentiated state. Dev. Dyn. 236, 1475–1483. https://doi.
org/10.1002/dvdy.21152
Nakata, K., Nagai, T., Aruga, J., Mikoshiba, K., 1998. Xenopus
Zic family and its role in neural and neural crest development. Mech. Dev. 75, 43–51. https://doi.org/10.1016/S09254773(98)00073-2
Naoki, H., Matsui, T., 2020. Somite boundary determination in normal and clock-less vertebrate embryos. Dev. Growth Differ.
62, 177–187. https://doi.org/10.1111/dgd.12655
Nichane, M., de Crozé, N., Ren, X., Souopgui, J., Monsoro-Burq,
A.H., Bellefroid, E.J., 2008a. Hairy2-Id3 interactions play
an essential role in Xenopus neural crest progenitor specif cation. Dev. Biol. 322, 355–367. https://doi.org/10.1016/j.
ydbio.2008.08.003
Nichane, M., Ren, X., Bellefroid, E.J., 2010. Self-regulation of
Stat3 activity coordinates cell-cycle progression and neural crest specif cation. EMBO J. 29, 55–67. https://doi.
org/10.1038/emboj.2009.313
Nichane, M., Ren, X., Souopgui, J., Bellefroid, E.J., 2008b. Hairy2
functions through both DNA-binding and non DNA-binding
mechanisms at the neural plate border in Xenopus. Dev. Biol.
322, 368–380. https://doi.org/10.1016/j.ydbio.2008.07.026
Nieber, F., Hedderich, M., Jahn, O., Pieler, T., Henningfeld,
K.A., 2013. NumbL is essential for Xenopus primary neurogenesis. BMC Dev. Biol. 13, 36. https://doi.org/10.1186/
1471-213X-13-36
Nimmo, R., Ciau-Uitz, A., Ruiz-Herguido, C., Soneji, S., Bigas, A.,
Patient, R., Enver, T., 2013. MiR-142–3p controls the specif -
cation of defnitive hemangioblasts during ontogeny. Dev. Cell
26, 237–249. https://doi.org/10.1016/j.devcel.2013.06.023
Oates, A.C., Morelli, L.G., Ares, S., 2012. Patterning embryos
with oscillations: Structure, function and dynamics of the
vertebrate segmentation clock. Development 139, 625–639.
https://doi.org/10.1242/dev.063735
Ogino, H., Fisher, M., Grainger, R.M., 2008. Convergence of a
head-feld selector Otx2 and Notch signaling: A mechanism
for lens specif cation. Development 135, 249–258. https://
doi.org/10.1242/dev.009548
Olson, E.C., Schinder, A.F., Dantzker, J.L., Marcus, E.A., Spitzer,
N.C., Harris, W.A., 1998. Properties of ectopic neurons
induced by Xenopus neurogenin1 misexpression. Mol.
Cell. Neurosci. 12, 281–299. https://doi.org/10.1006/mcne.
1998.0712
Onai, T., Aramaki, T., Inomata, H., Hirai, T., Kuratani, S., 2015. On
the origin of vertebrate somites. Zool. Lett. 1, 33. https://doi.
org/10.1186/s40851-015-0033-0
Oswald, F., Rodriguez, P., Giaimo, B.D., Antonello, Z.A., Mira, L.,
Mittler, G., Thiel, V.N., Collins, K.J., Tabaja, N., Cizelsky,
W., Rothe, M., Kühl, S.J., Kühl, M., Ferrante, F., Hein, K.,
Kovall, R.A., Dominguez, M., Borggrefe, T., 2016. A phospho-dependent mechanism involving NCoR and KMT2D
controls a permissive chromatin state at Notch target genes.
Nucleic Acids Res. 44, 4703–4720. https://doi.org/10.1093/
nar/gkw105
Paganelli, A.R., Ocaña, O.H., Prat, M.I., Franco, P.G., López, S.L.,
Morelli, L., Adamo, A.M., Riccomagno, M.M., Matsubara,
E., Shoji, M., Affranchino, J.L., Castaño, E.M., Carrasco,
A.E., 2001. The Alzheimer-related gene presenilin-1 facilitates Sonic hedgehog expression in Xenopus primary neurogenesis. Mech. Dev. 107, 119–131. https://doi.org/10.1016/
s0925-4773(01)00458-0
Notch Signaling in Early Embryogenesis
variability of expression profles of homeologous genes for
Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus
laevis. Dev. Biol. 426, 270–290. https://doi.org/10.1016/j.
ydbio.2016.12.006
Milet, C., Maczkowiak, F., Roche, D.D., Monsoro-Burq, A.H.,
2013. Pax3 and Zic1 drive induction and differentiation
of multipotent, migratory, and functional neural crest in
Xenopus embryos. Proc. Natl. Acad. Sci. U. S. A. 110, 5528–
5533. https://doi.org/10.1073/pnas.1219124110
Minsuk, S.B., Keller, R.E., 1997. Surface mesoderm in Xenopus:
A revision of the stage 10 fate map. Dev. Genes Evol. 207,
389–401. https://doi.org/10.1007/s004270050128
Mir, A., Kofron, M., Heasman, J., Mogle, M., Lang, S., Birsoy, B.,
Wylie, C., 2008. Long- and short-range signals control the
dynamic expression of an animal hemisphere-specifc gene in
Xenopus. Dev. Biol. 315, 161–172. https://doi.org/10.1016/j.
ydbio.2007.12.022
Mohr, O.L., 1919. Character changes caused by mutation of an
entire region of a chromosome in Drosophila. Genetics 4,
275–282.
Moody, S.A., 1987a. Fates of the blastomeres of the 16-cell stage
Xenopus embryo. Dev. Biol. 119, 560–578. https://doi.
org/10.1016/0012-1606(87)90059-5
Moody, S.A., 1987b. Fates of the blastomeres of the 32-cell-stage
Xenopus embryo. Dev. Biol. 122, 300–319. https://doi.
org/10.1016/0012-1606(87)90296-x
Moreno, T.A., Kintner, C., 2004. Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis. Dev. Cell 6, 205–218. https://doi.org/10.1016/
S1534-5807(04)00026-7
Morgan, T.H., 1917. The theory of the gene. Am. Nat. 51, 513–544.
https://doi.org/10.1086/279629
Muñoz-Descalzo, S., Sanders, P.G.T., Montagne, C., Johnson, R.I.,
Balayo, T., Martinez Arias, A., 2010. Wingless modulates
the ligand independent traffc of Notch through Dishevelled.
Fly (Austin). 4, 182–193. https://doi.org/10.4161/fly.4.3.
11998
Murai, K., Philpott, A., Jones, P.H., 2011. Hes6 is required for the
neurogenic activity of neurogenin and NeuroD. PLoS One 6,
e27880. https://doi.org/10.1371/journal.pone.0027880
Murai, K., Vernon, A.E., Philpott, A., Jones, P., 2007. Hes6 is
required for MyoD induction during gastrulation. Dev. Biol.
312, 61–76. https://doi.org/10.1016/j.ydbio.2007.09.011
Murato, Y., Hashimoto, C., 2009. Xhairy2 functions in Xenopus
lens development by regulating p27(xic1) expression. Dev.
Dyn. 238, 2179–2192. https://doi.org/10.1002/dvdy.21883
Murato, Y., Nagatomo, K., Yamaguti, M., Hashimoto, C., 2007.
Two alloalleles of Xenopus laevis hairy2 gene: Evolution
of duplicated gene function from a developmental perspective. Dev. Genes Evol. 217, 665–673. https://doi.org/10.1007/
s00427-007-0176-x
Murato, Y., Yamaguti, M., Katamura, M., Cho, K.W.Y., Hashimoto,
C., 2006. Two modes of action by which Xenopus hairy2b
establishes tissue demarcation in the Spemann-Mangold
organizer. Int. J. Dev. Biol. 50, 463–471. https://doi.org/
10.1387/ijdb.052106ym
Murgan, S., Castro Colabianchi, A.M., Monti, R.J., Boyadjián
López, L.E., Aguirre, C.E., Stivala, E.G., Carrasco, A.E.,
López, S.L., 2014. FoxA4 favours notochord formation by
inhibiting contiguous mesodermal fates and restricts anterior neural development in Xenopus embryos. PLoS One 9,
e110559. https://doi.org/10.1371/journal.pone.0110559
Nagano, T., Takehara, S., Takahashi, M., Aizawa, S., Yamamoto,
A., 2006. Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos.
Development 133, 4643–4654. https://doi.org/10.1242/
dev.02657
Nagatomo, K., Hashimoto, C., 2007. Xenopus hairy2 functions in
neural crest formation by maintaining cells in a mitotic and
undifferentiated state. Dev. Dyn. 236, 1475–1483. https://doi.
org/10.1002/dvdy.21152
Nakata, K., Nagai, T., Aruga, J., Mikoshiba, K., 1998. Xenopus
Zic family and its role in neural and neural crest development. Mech. Dev. 75, 43–51. https://doi.org/10.1016/S09254773(98)00073-2
Naoki, H., Matsui, T., 2020. Somite boundary determination in normal and clock-less vertebrate embryos. Dev. Growth Differ.
62, 177–187. https://doi.org/10.1111/dgd.12655
Nichane, M., de Crozé, N., Ren, X., Souopgui, J., Monsoro-Burq,
A.H., Bellefroid, E.J., 2008a. Hairy2-Id3 interactions play
an essential role in Xenopus neural crest progenitor specif cation. Dev. Biol. 322, 355–367. https://doi.org/10.1016/j.
ydbio.2008.08.003
Nichane, M., Ren, X., Bellefroid, E.J., 2010. Self-regulation of
Stat3 activity coordinates cell-cycle progression and neural crest specif cation. EMBO J. 29, 55–67. https://doi.
org/10.1038/emboj.2009.313
Nichane, M., Ren, X., Souopgui, J., Bellefroid, E.J., 2008b. Hairy2
functions through both DNA-binding and non DNA-binding
mechanisms at the neural plate border in Xenopus. Dev. Biol.
322, 368–380. https://doi.org/10.1016/j.ydbio.2008.07.026
Nieber, F., Hedderich, M., Jahn, O., Pieler, T., Henningfeld,
K.A., 2013. NumbL is essential for Xenopus primary neurogenesis. BMC Dev. Biol. 13, 36. https://doi.org/10.1186/
1471-213X-13-36
Nimmo, R., Ciau-Uitz, A., Ruiz-Herguido, C., Soneji, S., Bigas, A.,
Patient, R., Enver, T., 2013. MiR-142–3p controls the specif -
cation of defnitive hemangioblasts during ontogeny. Dev. Cell
26, 237–249. https://doi.org/10.1016/j.devcel.2013.06.023
Oates, A.C., Morelli, L.G., Ares, S., 2012. Patterning embryos
with oscillations: Structure, function and dynamics of the
vertebrate segmentation clock. Development 139, 625–639.
https://doi.org/10.1242/dev.063735
Ogino, H., Fisher, M., Grainger, R.M., 2008. Convergence of a
head-feld selector Otx2 and Notch signaling: A mechanism
for lens specif cation. Development 135, 249–258. https://
doi.org/10.1242/dev.009548
Olson, E.C., Schinder, A.F., Dantzker, J.L., Marcus, E.A., Spitzer,
N.C., Harris, W.A., 1998. Properties of ectopic neurons
induced by Xenopus neurogenin1 misexpression. Mol.
Cell. Neurosci. 12, 281–299. https://doi.org/10.1006/mcne.
1998.0712
Onai, T., Aramaki, T., Inomata, H., Hirai, T., Kuratani, S., 2015. On
the origin of vertebrate somites. Zool. Lett. 1, 33. https://doi.
org/10.1186/s40851-015-0033-0
Oswald, F., Rodriguez, P., Giaimo, B.D., Antonello, Z.A., Mira, L.,
Mittler, G., Thiel, V.N., Collins, K.J., Tabaja, N., Cizelsky,
W., Rothe, M., Kühl, S.J., Kühl, M., Ferrante, F., Hein, K.,
Kovall, R.A., Dominguez, M., Borggrefe, T., 2016. A phospho-dependent mechanism involving NCoR and KMT2D
controls a permissive chromatin state at Notch target genes.
Nucleic Acids Res. 44, 4703–4720. https://doi.org/10.1093/
nar/gkw105
Paganelli, A.R., Ocaña, O.H., Prat, M.I., Franco, P.G., López, S.L.,
Morelli, L., Adamo, A.M., Riccomagno, M.M., Matsubara,
E., Shoji, M., Affranchino, J.L., Castaño, E.M., Carrasco,
A.E., 2001. The Alzheimer-related gene presenilin-1 facilitates Sonic hedgehog expression in Xenopus primary neurogenesis. Mech. Dev. 107, 119–131. https://doi.org/10.1016/
s0925-4773(01)00458-0