87
hey1
hes7.3/esr5
dlc/
Positive in somitogenesis.
notch/
RBPJ
notch1
Positive.
notch1/
Negative during mesoderm induction.
hes5.1
dlc overexpression or RBPJ-Ank: expanded hes7.3/esr5
expression into the gaps of the somitomeric region (ISH
late neurula/early tailbud) ( Jen et al., 1999 ).
NICD1: ↑hes7.3/esr5 (NF28, microarray analysis) ( Vasiliu
et al., 2015 ).
NICD1: unable to induce hes7.3/esr5 in naive animal caps.
NICD1 or hes5.1: inhibited the induction of hes7.3/esr5 by
the mesodermal inducer nodal2 in animal caps (NF10.5,
sqRT-PCR).
hes5.1 overexpression : ↓hes7.3/esr5 in the IMZ (NF10.5,
ISH) ( Kinoshita et al., 2011 ).
RBPJ DBM : ↓hes7.3/esr5 in the somitomeric region and
the TZ but not in the TBD (ISH late neurula/early
tailbud) ( Jen et al., 1999 ).
hes5.1 ΔWRPW: ↑hes7.3/esr5 in animal caps
mesodermalized by nodal2 (NF10.5, sqRT-PCR)
( Kinoshita et al., 2011 ).
notch1/
Positive.
RBPJ
notch1/
Positive (head, somites, pronephros).
RBPJ
notch1
Positive.
RBPJ-Ank or NICD1: ectopic hey1 in whole embryos and
ectodermal explants (neurula) ( Pichon et al., 2002 ).
GR-NICD1 or GR-RBPJ-VP16, Dex NF11–13 or
NF15–19, ISH NF24–30:
↑hey1 in all domains, except in the pronephros with the
early Dex treatment (↓hey1) ( Rones et al., 2002 ).
NICD1: ↑hey1 (NF18, NF28, microarray analysis) ( Vasiliu
et al., 2015 ).
RBPJ DBM : ↓NICD1’s ability to induce ectopic hey1 in whole
embryos and ectodermal explants ( Pichon et al., 2002 ).
GR-RBPJ DBM, Dex NF11–13 or NF15–19
ISH NF24–30: ↓hey1 ( Rones et al., 2002 ).
Notch Signaling in Early Embryogenesis