G R O W T H I N D U C E D B Y D A M A G E
27
FIG. 11. The invasion of mouse skin b y a subcutaneous transplant of C-1498
leukemia tumor (from Argyris, 1966a).
subcutis does not result in the stimulation of growth of the adjacent connective tissue of the subcutis (Argyris, 1966b).
For the notion that the local loss of tissue mass does not result in
growth of the adjacent tissue to have general applicability, it is important
to demonstrate it in at least one other organ. Since we have previously
shown that damage to the mouse kidney b y the insertion of a needle
results in mitotic proliferation around the area of damage, we can
investigate if the loss of mass is responsible, in this case, for the stimulation of kidney mitotic activity (Argyris and Trimble, 1964b). T o determine if the loss of kidney cortical tissue is a sufficient stimulus for kidney
tissue proliferation, Argyris and Trimble (1964b) have inoculated a small
amount of Ehrlich ascites tumor under the right kidney capsule of a
mouse. T h e tumor grows and invades the kidney causing, within 5-7
days, a loss of kidney tissue equal to or exceeding that lost after needle
damage. In no case do the kidney cells bordering the growing tumor
27
FIG. 11. The invasion of mouse skin b y a subcutaneous transplant of C-1498
leukemia tumor (from Argyris, 1966a).
subcutis does not result in the stimulation of growth of the adjacent connective tissue of the subcutis (Argyris, 1966b).
For the notion that the local loss of tissue mass does not result in
growth of the adjacent tissue to have general applicability, it is important
to demonstrate it in at least one other organ. Since we have previously
shown that damage to the mouse kidney b y the insertion of a needle
results in mitotic proliferation around the area of damage, we can
investigate if the loss of mass is responsible, in this case, for the stimulation of kidney mitotic activity (Argyris and Trimble, 1964b). T o determine if the loss of kidney cortical tissue is a sufficient stimulus for kidney
tissue proliferation, Argyris and Trimble (1964b) have inoculated a small
amount of Ehrlich ascites tumor under the right kidney capsule of a
mouse. T h e tumor grows and invades the kidney causing, within 5-7
days, a loss of kidney tissue equal to or exceeding that lost after needle
damage. In no case do the kidney cells bordering the growing tumor