28
THOMAS S. ARGYRIS
show any obvious increase in mitotic activity. Also mitotic counts of the
remainder of the cortex reveal no general increase in mitotic activity
(Argyris, 1966b). To rule out the possibility that the lack of a proliferative response of the kidney cortical cells arises because they are incapacitated by the invading tumor, a number of experiments have been
performed.
The Ehrlich ascites tumor has been inoculated directly into the substance of kidney, thus damaging the kidney simultaneously with its
release. Within 2 days, there is a marked proliferative response by the
kidney cells adjacent to the areas of damage, as w
T
ell as tumor growth.
TABLE II
The Effect of Kidney Damage or Removal on the Mitotic Activity of Kidneys
Bearing Ehrlich Ascites Tumor
a
Kidney
Days postin which
kidneyNo. mitoses
mitotic
damage -
No. of
activity
or
100 000 cells
Treatment
mice
measured
removal
(Av. ± SE m )
c
Removal of the right kidney
13
Left kidney
2
53.7 ± 9.6
5 days after E.A.T.
6
inoculation into the left kidney
Damage to the right kidney
9
Left kidney
2
26.9 ± 4.5
5 days after E.A.T.
6
inoculation into the left kidney
° From Argyris and Trimble (1964b).
6
Ehrlich ascites tumor.
c
Average ± standard error of the mean.
Needle damage to a kidney in which the tumor has already been growing
for 5-7 days results in an increased mitotic activity on the part of the
kidney cells adjacent to the tumor and to the damage. Finally, we have
shown that the proliferative response of a kidney cortex bearing a tumor
implant to the removal of the contralateral kidney is as much as the
proliferative response of a normal kidney cortex to the removal of the
contralateral kidney (Table II).
Further support that the loss of mass is insufficient to initiate growth
is provided by the observation that needle damage to one kidney not only
results in mitotic activity in the damaged kidney, but also causes a
general increase in the cortical mitotic activity of the contralateral kidney
(Table III). But, the loss of mass equal or exceeding that produced by
THOMAS S. ARGYRIS
show any obvious increase in mitotic activity. Also mitotic counts of the
remainder of the cortex reveal no general increase in mitotic activity
(Argyris, 1966b). To rule out the possibility that the lack of a proliferative response of the kidney cortical cells arises because they are incapacitated by the invading tumor, a number of experiments have been
performed.
The Ehrlich ascites tumor has been inoculated directly into the substance of kidney, thus damaging the kidney simultaneously with its
release. Within 2 days, there is a marked proliferative response by the
kidney cells adjacent to the areas of damage, as w
T
ell as tumor growth.
TABLE II
The Effect of Kidney Damage or Removal on the Mitotic Activity of Kidneys
Bearing Ehrlich Ascites Tumor
a
Kidney
Days postin which
kidneyNo. mitoses
mitotic
damage -
No. of
activity
or
100 000 cells
Treatment
mice
measured
removal
(Av. ± SE m )
c
Removal of the right kidney
13
Left kidney
2
53.7 ± 9.6
5 days after E.A.T.
6
inoculation into the left kidney
Damage to the right kidney
9
Left kidney
2
26.9 ± 4.5
5 days after E.A.T.
6
inoculation into the left kidney
° From Argyris and Trimble (1964b).
6
Ehrlich ascites tumor.
c
Average ± standard error of the mean.
Needle damage to a kidney in which the tumor has already been growing
for 5-7 days results in an increased mitotic activity on the part of the
kidney cells adjacent to the tumor and to the damage. Finally, we have
shown that the proliferative response of a kidney cortex bearing a tumor
implant to the removal of the contralateral kidney is as much as the
proliferative response of a normal kidney cortex to the removal of the
contralateral kidney (Table II).
Further support that the loss of mass is insufficient to initiate growth
is provided by the observation that needle damage to one kidney not only
results in mitotic activity in the damaged kidney, but also causes a
general increase in the cortical mitotic activity of the contralateral kidney
(Table III). But, the loss of mass equal or exceeding that produced by