36
ORGANIC SYNTHESIS—1995
I.A.7.a.3-6 Yus, M. et al., T, 50, 3447 & 13269, TL, 35, 4831, see
also: TL, 35, 253; Yoshikawa, M. et al., CPB, 42, 994; Sarangi, C, Das,
N.B. and Sharma, R.P., JCR(S), 398.
Λ
ϋ powder
O H
A
R 2 DTBB,THF
R ^ ^ R
2
R
21-62%
various other Barbier-type reactions explored
I.A.7.a.3-7 Yus, M. et al., T, 50, 3437.
° \ ^ 0
ff
1) Li powder
JL
f i l
+
R ^ R
2
DTBB,THF*
|
|
R i
I
y
2) aq. HC1
Γ^"
OH
33-40% R
2
I.A.7.a.3-8 Zadel, G. and Breitmaier, E., CB, 127, 1323; Marko, I.E. et
al., TA, 5, 569.
ff
3
THF
R 3
R
1
R i / \ R 2
diamine
A T ~
O H
51-95%, 37-97% ee
ÌnP =
L Γ
diamine =
TL·^
ORGANIC SYNTHESIS—1995
I.A.7.a.3-6 Yus, M. et al., T, 50, 3447 & 13269, TL, 35, 4831, see
also: TL, 35, 253; Yoshikawa, M. et al., CPB, 42, 994; Sarangi, C, Das,
N.B. and Sharma, R.P., JCR(S), 398.
Λ
ϋ powder
O H
A
R 2 DTBB,THF
R ^ ^ R
2
R
21-62%
various other Barbier-type reactions explored
I.A.7.a.3-7 Yus, M. et al., T, 50, 3437.
° \ ^ 0
ff
1) Li powder
JL
f i l
+
R ^ R
2
DTBB,THF*
|
|
R i
I
y
2) aq. HC1
Γ^"
OH
33-40% R
2
I.A.7.a.3-8 Zadel, G. and Breitmaier, E., CB, 127, 1323; Marko, I.E. et
al., TA, 5, 569.
ff
3
THF
R 3
R
1
R i / \ R 2
diamine
A T ~
O H
51-95%, 37-97% ee
ÌnP =
L Γ
diamine =
TL·^