CARBON-CARBON BOND FORMING REACTIONS
35
I.A.7.a.3-4 Cohen, T. et al, T, 50, 11569 & 12793; Schmidt, U. and
Schmidt, J., S, 300; Yus, M. et al., TL, 35, 7643; Barluenga, J. et al., JOC,
59, 1586; Piers, E. et al., TL, 35, 8573; Shimano, M. and Meyers, A.L, TL,
35, 7727; Hu, C. et al., CC, 289.
1) LDBB, -78°C O
(y
2)DMF
SPh
80%
CHO
LDBB = 4,4*-di-tert-butylphenylide
various other routes to vinyl lithium (& Zn) species & reactions
with other electrophiles reported
I.A.7.a.3-5 Denmark, S.E. et al., JACS, 116, 8797; Matsubara, S.,
Utimoto, K. et al., CL, 831.
„OMe
OMe
R
1 ^ R
2
79-97%, 30-91% ee
R
J = Et, 'Bu
35
I.A.7.a.3-4 Cohen, T. et al, T, 50, 11569 & 12793; Schmidt, U. and
Schmidt, J., S, 300; Yus, M. et al., TL, 35, 7643; Barluenga, J. et al., JOC,
59, 1586; Piers, E. et al., TL, 35, 8573; Shimano, M. and Meyers, A.L, TL,
35, 7727; Hu, C. et al., CC, 289.
1) LDBB, -78°C O
(y
2)DMF
SPh
80%
CHO
LDBB = 4,4*-di-tert-butylphenylide
various other routes to vinyl lithium (& Zn) species & reactions
with other electrophiles reported
I.A.7.a.3-5 Denmark, S.E. et al., JACS, 116, 8797; Matsubara, S.,
Utimoto, K. et al., CL, 831.
„OMe
OMe
R
1 ^ R
2
79-97%, 30-91% ee
R
J = Et, 'Bu