CARBON-CARBON BOND FORMING REACTIONS
I.A.5-7 Kim, S. et al., CC, 1188.
17
TBSOTf
RMgX
Me 2 S
various other nucleophiles used
82-94%
I.A.5-8 Higashiyama, K. et al., T, 50, 1083; Pridgen, L.N. et al., TL, 35,
7489; Scialdone, M.A. and Meyers, A.I., TL, 35, 7533; Nishiyama, T. et
al., BCJ, 67, 1765; see also: Nakai, T. et al., TL, 35, 1913.
Eh
)Me
HN
>
MeO
A/
Ph
MgBr
HN^°
H
Ar
OMe
OMe 58-64%
similarly with organocerium or zinc species or with acetals
I.A.5-9 Pridgen, L.N. et al., TL, 35, 4267.
RMgX
1) R'l
►
2) H 3 0
+
R' = Me, allyl
70-87%, 74-99% ee
I.A.5-7 Kim, S. et al., CC, 1188.
17
TBSOTf
RMgX
Me 2 S
various other nucleophiles used
82-94%
I.A.5-8 Higashiyama, K. et al., T, 50, 1083; Pridgen, L.N. et al., TL, 35,
7489; Scialdone, M.A. and Meyers, A.I., TL, 35, 7533; Nishiyama, T. et
al., BCJ, 67, 1765; see also: Nakai, T. et al., TL, 35, 1913.
Eh
)Me
HN
>
MeO
A/
Ph
MgBr
HN^°
H
Ar
OMe
OMe 58-64%
similarly with organocerium or zinc species or with acetals
I.A.5-9 Pridgen, L.N. et al., TL, 35, 4267.
RMgX
1) R'l
►
2) H 3 0
+
R' = Me, allyl
70-87%, 74-99% ee