18
ORGANIC SYNTHESIS—1995
I.A.5-10 Indolese, A.F. and Consiglio, G., OM, 13, 2230.
RMgBr +
|
Ph
X 2 N
0·
*
n
[a chiral phosphine]
yjn
n = l,2
0.5-99%, 8-93% ee
LA.5-11 Backvall, J.-E. et al., JOC, 59, 4126; Backvall, J.-E., van
Koten, G. et al., TL, 35, 5931.
Cf\
PhCu(X)MgBr
AcÖ ^ ^ ^
AcÖ
,\
v Ph
AcÖ
X = C1 9 : 91
X = Br 25 : 75
X = I 34 : 66
Ph
I.A.5-12 Kang, S.-K. et al., TA, 5, 21.
BnO.
EtMgBr, BF 3 »OEt 2
Cui, -78°C
BnO.
OH
84%, 100% ds
ORGANIC SYNTHESIS—1995
I.A.5-10 Indolese, A.F. and Consiglio, G., OM, 13, 2230.
RMgBr +
|
Ph
X 2 N
0·
*
n
[a chiral phosphine]
yjn
n = l,2
0.5-99%, 8-93% ee
LA.5-11 Backvall, J.-E. et al., JOC, 59, 4126; Backvall, J.-E., van
Koten, G. et al., TL, 35, 5931.
Cf\
PhCu(X)MgBr
AcÖ ^ ^ ^
AcÖ
,\
v Ph
AcÖ
X = C1 9 : 91
X = Br 25 : 75
X = I 34 : 66
Ph
I.A.5-12 Kang, S.-K. et al., TA, 5, 21.
BnO.
EtMgBr, BF 3 »OEt 2
Cui, -78°C
BnO.
OH
84%, 100% ds