16
ORGANIC SYNTHESIS—1995
I.A.5-4 Azzena, U. et al., TL, 35, 6759 and SC, 24, 591.
CH 3 (K
/OCH 3
1) Li, THF
Ε ^ /OCH 3
CR
►
CR
I
2) E X
I
Ar
Ar
52-92%
I.A.5-5 Narasaka, K. et al., BCJ, 67, 1156.
Cr(CO) 3
TIPS
RLi
THF, HMPA
-78°C
73-95%
I.A.5-6 Lautens, M. et al., CC, 1193; Arjona, O., Fernandez de la Prastilla,
R., Plumet, J. et al., JOC, 59, 3906; see also: Stille, J.R. et al., OM, 13,
1456.
OTBS
OTBS
V
RLi
pentane-hexane HO'
OTBS (-)-Sparteine
.»*
\
R
R
K
69%, 52% ee
OH
intramolecular S N 2 ' reactions also reported
ORGANIC SYNTHESIS—1995
I.A.5-4 Azzena, U. et al., TL, 35, 6759 and SC, 24, 591.
CH 3 (K
/OCH 3
1) Li, THF
Ε ^ /OCH 3
CR
►
CR
I
2) E X
I
Ar
Ar
52-92%
I.A.5-5 Narasaka, K. et al., BCJ, 67, 1156.
Cr(CO) 3
TIPS
RLi
THF, HMPA
-78°C
73-95%
I.A.5-6 Lautens, M. et al., CC, 1193; Arjona, O., Fernandez de la Prastilla,
R., Plumet, J. et al., JOC, 59, 3906; see also: Stille, J.R. et al., OM, 13,
1456.
OTBS
OTBS
V
RLi
pentane-hexane HO'
OTBS (-)-Sparteine
.»*
\
R
R
K
69%, 52% ee
OH
intramolecular S N 2 ' reactions also reported