Tang G, Galili G, Zhuang X (2007) RNAi and microRNA: breakthrough technologies for the
improvement of plant nutritional value and metabolic engineering. Metabolomics 3:357–369
Tissot G, Canard H, Nadai M, Martone A, Botterman J, Dubald M (2008) Translocation of
aprotinin, a therapeutic protease inhibitor, into the thylakoid lumen of genetically engineered
tobacco chloroplasts. Plant Biotechnol J 6:309–320
Tran M, Zhou B, Pettersson PL, Gonzalez MJ, Mayfield SP (2009) Synthesis and assembly of a
full-length human monoclonal antibody in algal chloroplasts. Biotechnol Bioeng 104:663–673
Turpen TH, Reinl SJ, Charoenvit Y, Hoffman SL, Fallarme V, Grill LK (1995) Malaria epitopes
expressed on the surface of recombinant tobacco mosaic virus. Nat Biotechnol 13:53–57
Twyman RM, Christou P, Stoger E (2002) Genetic transformation of plants and their cells. Plant
Biotechnol and Transgenic Plants. Marcel Dekker Inc, New York, pp 111–141
Valderrama F, Arango I, Afanador K (2005) Plant transformation mediated by Agrobacterium:
applied natural genetic engineering. Rev Fac Nal Agr Medellín 59:2569–2585
Van Erp H, Bates PD, Burgal J, Shockey J, Browse J (2011) Castor phospholipid: diacylglycerol
acyltransferase facilitates efficient metabolism of hydroxy fatty acids in transgenic
Arabidopsis. Plant Physiol 155:683–693
Vasil IK (1990) The realities and challenges of plant biotechnology. Bio/Technology 8:231–296
Verpoorte R, Memelink J (2002) Engineering secondary metabolite production in plants. Curr
Opin Biotechnol 13:181–187
Wada N, Kajiyama SI, Akiyama Y, Kawakami S, No D, Uchiyama S, Otani M, Shimada T, Nose
N, Suzuki G, Mukai Y, Fukui K (2009) Bioactive beads-mediated transformation of rice with
large DNA fragments containing Aegilops tauschii genes. Plant Cell Rep 28:759–768
Walker TL, Purton S, Becker DK, Collet C (2005) Microalgae as bioreactors. Plant Cell Rep
24:629–641
Welle R, Grisbach J (1988) Isolation of anobel NADPH-dependent reductase wihich co-acts with
chalcone synthase in the biosynthesis of 6’-deoxychalcone. FEBS Left 236:221–225
Wiechert W (2001)
13
C metabolic flux analysis. Metab Eng 3:195–206
Wijffels RH, Barbosa MJ (2010) An outlook on microalgal biofuels. Science 329:796–799
Woolston BM, Edgar S, Stephanopoulos G (2013) Metabolic engineering: past and future. Ann
Rev Chem Biomol Eng 4:259–288
Wu G, Truksa M, Datla N, Vrinten P, Bauer J, Zank T, Cirpus P, Heinz E, Qiu X (2005) Stepwise
engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants.
Nat Biotechnol 23:1013–1017
Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P, Potrykus I (2000) Engineering the
provitamin A (b-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm.
Science 287:303–305
Yokotani N, Ichikawa T, Kondou Y, Iwabuchi M, Matsui M, Hirochika H, Oda K (2013) Role of
the rice transcription factor JAmyb in abiotic stress response. J Plant Res 126:131–139
Yonekura-Sakakibara K, Fukushima A, Saito K (2013) Transcriptome data modeling for targeted
plant metabolic engineering. Curr Opin Biotech 24:285–290
Yu W, Han F, Gao Z, Vega JM, Birchler JA (2007) Construction and behavior of engineered
minichromosomes in maize. Proc Nat Acad Sci USA 104:8924–8929
Yu A, Lepère G, Jay F, Wang J, Bapaume L, Wang Y, Navarro L (2013) Dynamics and
biological relevance of DNA demethylation in Arabidopsis antibacterial defense. Proc Nat
Acad Sci USA 110:2389–2394
Zhang G, Chen M, Li L, Xu Z, Chen X, Guo J, Ma Y (2009) Overexpression of the soybean
GmERF3 gene, an AP2/ERF type transcription factor for increased tolerances to salt, drought,
and diseases in transgenic tobacco. J Exp Bot 60:3781–3796
Zhang Y, Yan YP, Wang ZZ (2010) The Arabidopsis PAP1transcription factor plays an important
role in the enrichment of phenolic acids in Salvia miltiorrhiza. J Agric Food Chem
58:12168–12175
Zhang L, Wang Y, Zhang X, Zhang M, Han D, Qiu C, Ha Z (2012) Dynamics of phytohormone and
DNA methylation patterns changes during dormancy induction in strawberry (Fragaria
9 ananassa Duch.). Plant Cell Rep 31:155–165
15 Plants as Bioreactors for Human Health Nutrients
453
improvement of plant nutritional value and metabolic engineering. Metabolomics 3:357–369
Tissot G, Canard H, Nadai M, Martone A, Botterman J, Dubald M (2008) Translocation of
aprotinin, a therapeutic protease inhibitor, into the thylakoid lumen of genetically engineered
tobacco chloroplasts. Plant Biotechnol J 6:309–320
Tran M, Zhou B, Pettersson PL, Gonzalez MJ, Mayfield SP (2009) Synthesis and assembly of a
full-length human monoclonal antibody in algal chloroplasts. Biotechnol Bioeng 104:663–673
Turpen TH, Reinl SJ, Charoenvit Y, Hoffman SL, Fallarme V, Grill LK (1995) Malaria epitopes
expressed on the surface of recombinant tobacco mosaic virus. Nat Biotechnol 13:53–57
Twyman RM, Christou P, Stoger E (2002) Genetic transformation of plants and their cells. Plant
Biotechnol and Transgenic Plants. Marcel Dekker Inc, New York, pp 111–141
Valderrama F, Arango I, Afanador K (2005) Plant transformation mediated by Agrobacterium:
applied natural genetic engineering. Rev Fac Nal Agr Medellín 59:2569–2585
Van Erp H, Bates PD, Burgal J, Shockey J, Browse J (2011) Castor phospholipid: diacylglycerol
acyltransferase facilitates efficient metabolism of hydroxy fatty acids in transgenic
Arabidopsis. Plant Physiol 155:683–693
Vasil IK (1990) The realities and challenges of plant biotechnology. Bio/Technology 8:231–296
Verpoorte R, Memelink J (2002) Engineering secondary metabolite production in plants. Curr
Opin Biotechnol 13:181–187
Wada N, Kajiyama SI, Akiyama Y, Kawakami S, No D, Uchiyama S, Otani M, Shimada T, Nose
N, Suzuki G, Mukai Y, Fukui K (2009) Bioactive beads-mediated transformation of rice with
large DNA fragments containing Aegilops tauschii genes. Plant Cell Rep 28:759–768
Walker TL, Purton S, Becker DK, Collet C (2005) Microalgae as bioreactors. Plant Cell Rep
24:629–641
Welle R, Grisbach J (1988) Isolation of anobel NADPH-dependent reductase wihich co-acts with
chalcone synthase in the biosynthesis of 6’-deoxychalcone. FEBS Left 236:221–225
Wiechert W (2001)
13
C metabolic flux analysis. Metab Eng 3:195–206
Wijffels RH, Barbosa MJ (2010) An outlook on microalgal biofuels. Science 329:796–799
Woolston BM, Edgar S, Stephanopoulos G (2013) Metabolic engineering: past and future. Ann
Rev Chem Biomol Eng 4:259–288
Wu G, Truksa M, Datla N, Vrinten P, Bauer J, Zank T, Cirpus P, Heinz E, Qiu X (2005) Stepwise
engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants.
Nat Biotechnol 23:1013–1017
Ye X, Al-Babili S, Klöti A, Zhang J, Lucca P, Beyer P, Potrykus I (2000) Engineering the
provitamin A (b-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm.
Science 287:303–305
Yokotani N, Ichikawa T, Kondou Y, Iwabuchi M, Matsui M, Hirochika H, Oda K (2013) Role of
the rice transcription factor JAmyb in abiotic stress response. J Plant Res 126:131–139
Yonekura-Sakakibara K, Fukushima A, Saito K (2013) Transcriptome data modeling for targeted
plant metabolic engineering. Curr Opin Biotech 24:285–290
Yu W, Han F, Gao Z, Vega JM, Birchler JA (2007) Construction and behavior of engineered
minichromosomes in maize. Proc Nat Acad Sci USA 104:8924–8929
Yu A, Lepère G, Jay F, Wang J, Bapaume L, Wang Y, Navarro L (2013) Dynamics and
biological relevance of DNA demethylation in Arabidopsis antibacterial defense. Proc Nat
Acad Sci USA 110:2389–2394
Zhang G, Chen M, Li L, Xu Z, Chen X, Guo J, Ma Y (2009) Overexpression of the soybean
GmERF3 gene, an AP2/ERF type transcription factor for increased tolerances to salt, drought,
and diseases in transgenic tobacco. J Exp Bot 60:3781–3796
Zhang Y, Yan YP, Wang ZZ (2010) The Arabidopsis PAP1transcription factor plays an important
role in the enrichment of phenolic acids in Salvia miltiorrhiza. J Agric Food Chem
58:12168–12175
Zhang L, Wang Y, Zhang X, Zhang M, Han D, Qiu C, Ha Z (2012) Dynamics of phytohormone and
DNA methylation patterns changes during dormancy induction in strawberry (Fragaria
9 ananassa Duch.). Plant Cell Rep 31:155–165
15 Plants as Bioreactors for Human Health Nutrients
453