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natural, non-caloric sweetener. Food Chem Toxicol 46:S75–S82
Qaim M (2010) Benefits of genetically modified crops for the poor: household income, nutrition,
and health. New Biotechnol 27:552–557
Qi B, Fraser T, Mugford S, Dobson G, Sayanova O, Butler J, Napier J, Stobar A, Lazarus CM
(2004) Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in
plants. Nat Biotechnol 22:739–745
Raja R, Hemaiswarya S, Kumar NA, Sridhar S, Rengasamy R (2008) A perspective on the
biotechnological potential of microalgae. Crit Rev Microbiol 34:77–88
Ramachandra-Rao S, Ravishankar GA (2002) Plant cell cultures: chemical factories of secondary
metabolites. Biotechnol Adv 10:101–153
Riechmann JL, Heard J, Martin G, Reuber L, Keddie J, Adam L, Pineda O, Ratcliffe OJ, Samaha
R, Creelman R, Pilgrim M, Broun P, Zhang J, Ghandehari D, Sherman BK, Yu GL (2000)
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
Science 290:2105–2110
Ruban AV, Young AJ, Pascal AA, Horton P (1994) The effects of illumination on the xanthophyll
composition of the photosystem II light-harvesting complexes of spinach thylakoid
membranes. Plant Physiol 104:227–234
Runguphan W, Maresh JJ, O’Connor SE (2009) Silencing of tryptamine biosynthesis for
production of non-natural alkaloids in plant culture. Proc Nat Acad Sci USA
106:13673–13678
Saze H, Scheid OM, Paszkowski J (2003) Maintenance of CpG methylation is essential for
epigenetic inheritance during plant gametogenesis. Nat Gen 34:65–69
Schijlen EGWM, Ric de vos CH, Van Tunen AJ, Bovy AG (2004) Modification of flavonoids
biosynthesis in crop plants. Phytochemistry 65:2632–2648
Schwab W, Davidovich-Rikanati R, Lewinsohn E (2008) Biosynthesis of plant-derived flavor
compounds. Plant J 54:712–732
Schwender J (2008) Metabolic flux analysis as a tool in metabolic engineering of plants. Curr
Opin Biotechnol 19:131–137
Schwinn K, Venail J, Shang Y, Mackay S, Alm V, Butelli E, Oyama R, Bailey P, Davies K,
Martin C (2006) A small family of MYB-regulatory genes controls floral pigmentation
intensity and patterning in the genus Anthirrhinum. Plant Cell 18:831–851
Sethuraman N, Stadheim TA (2006) Challenges in therapeutic glycoprotein production. Curr
Opin Biotechnol 17:341–346
Shadwick FS, Doran PM (2007) Infection, propagation, distribution and stability of plant virus in
hairy root cultures. J Biotechnol 131:318–329
Shahijram L, Soneji J, Bollama K (2003) Analyzing somaclonal variation in micropropagated
bananas (Musa spp.). In Vitro Cell Dev Biol Plant 39:551–556
Sharma AK, Sharma MK (2009) Plants as bioreactors: recent developments and emerging
opportunities. Biotechnol Adv 27:811–832
Sijmons PC, Dekker BMM, Schrammeijer B, Verwoerd TC, van den Elzen PJM, Hoekema A
(1990) Production of correctly processed human serum albumin in transgenic plants. Nat
Biotechnol 8:217–221
Skarjinskaia M, Ruby K, Araujo A, Taylor K, Gopalasamy-Raju V, Musiychuk K, Chichester JA,
Palmer GA, de la Rosa P, Mett V, Ugulava N, Streatfield SJ, Yusibov V (2013) Hairy roots as
a vaccine production and delivery system. Adv Biochem Eng Biotechnol 134:115–134
Sone T, Nagamori E, Ikeuchi T, Mizukami A, Takakura Y, Kajiyama SI, Fukui K (2002) A novel
gene delivery system in plants with calcium alginate micro-beads. J Biosci Bioeng 94:87–91
Stein H, Wilensky M, Tsafrir Y, Rosenthal M, Amir R, Avraham T, Ofir K, Dgany O, Yanon A,
Shoseyov O (2009) Production of bioactive, post-translationally modified, heterotrimeric,
human recombinant type-I collagen in transgenic tobacco. Biomacromolecules 10:2640–2645
Syklowska-Baranek K, Pietrosiuk A, Kokoszka A, Furmanowa M (2009) Enhancement of taxane
production in hairy root culture of Taxus x media var Hicksii. J Plant Physiol 166:1950–1954
452
L. A. Cruz-Ramírez et al.