Triose P
(
)
a
Glucose
Glucose 6 - P
6 - P
P
Fructose
Fructose
3 - Phosphoglyceraldehyde
Phosphodihydroxyacetone
NADH,H +
6
5
1,3 - Phosphoglycerate
3 - Phosphoglycerate
2 - Phosphoglycerate
9
Phosphoenolpyruvate
Pyruvate
1
1,6 -
7
8
10
4
3
2
Pi
ATP
ATP
ATP
ATP
x 2
6
5
4
3
2
1
8
7
Acetyl - CoA
CoA
H 2 O
H 2 O
Citrate
Isocitrate
CO 2
NADPH, H
+
- Ketoglutarate
CoA
CO 2
NADH, H
+
NADH, H
+
Succinyl-CoA
Succinate
CoA
ATP
GTP
ou
FADH 2
Fumarate
Malate
Oxaloacetate
b
1
T.A.C.
ADP + Pi
ATP
Glucose
2 ADP
2 ATP
Glycolysis
(2) Pyruvate
(2) CO 2
(4) CO 2
(2) CoA (2) Acetyl - CoA
+
(2) FADH, H
+
(2) NAD(P)H, H
+
(2) NADH, H
+
(2) NADH, H
+
(2) NADH, H
+
2 FAD
2 NAD(P)
+
8 NAD
e -
O 2
2 H 2 O
H
+
H
+
Cytoplasmic
membrane
(2) NADH, H
+
2
c
Fig. 3.13 Catabolism of glucose. (a) Glycolysis, a degradation
pathway of glucose. 1 Glucokinase, 2 glucomutase, 3 phosphofructokinase, 4 aldolase, 5 isomerase, 6 3-phosphoglyceraldehyde dehydrogenase, 7 3-phosphoglycerate kinase, 8 phosphoglycerate mutase, 9
enolase, and 10 pyruvate kinase. Pi inorganic phosphate, triose
phosphates 3-phosphoglyceraldehyde, and phosphodihydroxyace ´tone. (b) The Krebs cycle (tricarboxylic acid cycle, TAC). 1
Citrate synthase, 2 aconitate hydratase, 3 isocitrate dehydrogenase,
4 ketoglutarate dehydrogenase, 5 succinate thiokinase, 6 succinate
dehydrogenase, 7 fumarase, and 8 malate dehydrogenase. (c) Scheme
of glucose catabolism: glycolysis and Krebs cycle and electron transfer through the membrane respiratory chain. 1 Substrate-level phosphorylation, 2 oxidative phosphorylation via proton pores and ATP
synthases (Drawing: M.-J. Bodiou)
3 Structure and Functions of Microorganisms: Production and Use of Material and Energy
39