Jones T, Spencer R, Walsh C (1978) Mechanism and kinetics of iron release from ferritin by
dihydroflavins and dihydroflavin analogues. Biochemistry 17:4011–4017
Lawson TL, Crow A, Lewin A, Yasmin S, Moore GR, Le Brun NE (2009) Monitoring the iron
status of the ferroxidase center of Escherichia coli bacterioferritin using fluorescence spectroscopy. Biochemistry 48:9031–9039
Le Brun NE, Wilson MT, Andrews SC, Guest JR, Harrison PM, Thomson AJ, Moore GR (1993)
Kinetic and structural characterization of an intermediate in the biomineralization of bacterioferritin. FEBS Lett 333:197–202
Le Brun NE, Crow A, Murphy ME, Mauk AG, Moore GR (2010) Iron core mineralisation in
prokaryotic ferritins. Biochim Biophys Acta 1800(8):732–744
Lewin, A, Moore, GR, and Le Brun, NE (2005) Formation of protein-coated iron minerals. Dalton
Trans 3597–3610
Liu X, Theil EC (2005) Ferritin: dynamic management of biological iron and oxygen chemistry.
Acc Chem Res 38:167–175
Liu X, Jin W, Theil EC (2003) Opening protein pores with chaotropes enhances Fe reduction and
chelation of Fe from the ferritin biomineral. Proc. Natl. Acad. Sci. U. S. A. Proc Natl Acad Sci
100:3653–3658
Liu X, Kim K, Leighton T, Theil EC (2006) Paired Bacillus anthracis Dps (mini-ferritin) have
different reactivities with peroxide. J Biol Chem 28:27827–27835
Liu XS, Patterson LD, Miller MJ, Theil EC (2007) Peptides Selected for the Protein Nanocage
Pores Change the Rate of Iron Recovery from the Ferritin Mineral. J Biol Chem J Biol Chem
282:31821–31825
Mann S, Williams JM, Treffry A, Harrison PM (1987) Reconstituted and native iron-cores of
bacterioferritin and ferritin. J Mol Biol 198:405–416
Moe ¨nne-Loccoz P, Krebs C, Herlihy K, Edmondson DE, Theil EC, Huynh BH, Loehr TM (1999)
The ferroxidase reaction of ferritin reveals a diferric m-1,2 bridging peroxide intermediate in
common with other O 2 -activating non-heme diiron proteins. Biochemistry 38:5290–5295
Nandal A, Huggins CC, Woodhall MR, McHugh J, Rodriguez-Quinones F, Quail MA, Guest JR,
Andrews SC (2009) Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is
mediated by reversal of H-NS silencing and is RyhB independent. Mol Microbiol 75
(3):637–657
Pereira A, Small GS, Krebs C, Tavares P, Edmondson DE, Theil EC, Huynh BH (1998) Direct
spectroscopic and kinetic evidence for the involvement of a peroxodiferric intermediate during
the ferroxidase reaction in fast ferritin mineralization. Biochemistry 37:9871–9876
Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E,
Cong R, Beaumont C, Torti FM, Torti SV, Franzoso G (2004) Ferritin heavy chain
upregulation by NF-kB inhibits TNFa-induced apoptosis by suppressing reactive oxygen
species. Cell 119:529–542
Richards TD, Pitts KR, Watt GD (1996) A kinetic study of iron release from Azotobacter
vinelandii bacterial ferritin, J Inorg Biochem 61:1–13
Rodriguez N, Menendez N, Tornero J, Amils R, de la Fuente V (2005) Internal iron biomineralization in Imperata cylindrica, a perennial grass: chemical composition, speciation and plant
localization. New Phytol 165:781–789
Rohrer JS, Islam QT, Watt GD, Sayers DE, Theil EC (1990) Iron environment in ferritin with large
amounts of phosphate, from Azotobacter vinelandii and horse spleen, analyzed using extended
x-ray absorption fine structure (EXAFS). Biochemistry 29:259–264
Schwartz JK, Liu XS, Tosha T, Theil EC, Solomon EI (2008) Spectroscopic definition of the
ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sites. J Am
Chem Soc 130:9441–9450
Semenza GL (2009) Involvement of oxygen-sensing pathways in physiologic and pathologic
erythropoiesis. Blood 114:2015–2019
46
L.E. Bevers and E.C. Theil
dihydroflavins and dihydroflavin analogues. Biochemistry 17:4011–4017
Lawson TL, Crow A, Lewin A, Yasmin S, Moore GR, Le Brun NE (2009) Monitoring the iron
status of the ferroxidase center of Escherichia coli bacterioferritin using fluorescence spectroscopy. Biochemistry 48:9031–9039
Le Brun NE, Wilson MT, Andrews SC, Guest JR, Harrison PM, Thomson AJ, Moore GR (1993)
Kinetic and structural characterization of an intermediate in the biomineralization of bacterioferritin. FEBS Lett 333:197–202
Le Brun NE, Crow A, Murphy ME, Mauk AG, Moore GR (2010) Iron core mineralisation in
prokaryotic ferritins. Biochim Biophys Acta 1800(8):732–744
Lewin, A, Moore, GR, and Le Brun, NE (2005) Formation of protein-coated iron minerals. Dalton
Trans 3597–3610
Liu X, Theil EC (2005) Ferritin: dynamic management of biological iron and oxygen chemistry.
Acc Chem Res 38:167–175
Liu X, Jin W, Theil EC (2003) Opening protein pores with chaotropes enhances Fe reduction and
chelation of Fe from the ferritin biomineral. Proc. Natl. Acad. Sci. U. S. A. Proc Natl Acad Sci
100:3653–3658
Liu X, Kim K, Leighton T, Theil EC (2006) Paired Bacillus anthracis Dps (mini-ferritin) have
different reactivities with peroxide. J Biol Chem 28:27827–27835
Liu XS, Patterson LD, Miller MJ, Theil EC (2007) Peptides Selected for the Protein Nanocage
Pores Change the Rate of Iron Recovery from the Ferritin Mineral. J Biol Chem J Biol Chem
282:31821–31825
Mann S, Williams JM, Treffry A, Harrison PM (1987) Reconstituted and native iron-cores of
bacterioferritin and ferritin. J Mol Biol 198:405–416
Moe ¨nne-Loccoz P, Krebs C, Herlihy K, Edmondson DE, Theil EC, Huynh BH, Loehr TM (1999)
The ferroxidase reaction of ferritin reveals a diferric m-1,2 bridging peroxide intermediate in
common with other O 2 -activating non-heme diiron proteins. Biochemistry 38:5290–5295
Nandal A, Huggins CC, Woodhall MR, McHugh J, Rodriguez-Quinones F, Quail MA, Guest JR,
Andrews SC (2009) Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is
mediated by reversal of H-NS silencing and is RyhB independent. Mol Microbiol 75
(3):637–657
Pereira A, Small GS, Krebs C, Tavares P, Edmondson DE, Theil EC, Huynh BH (1998) Direct
spectroscopic and kinetic evidence for the involvement of a peroxodiferric intermediate during
the ferroxidase reaction in fast ferritin mineralization. Biochemistry 37:9871–9876
Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E,
Cong R, Beaumont C, Torti FM, Torti SV, Franzoso G (2004) Ferritin heavy chain
upregulation by NF-kB inhibits TNFa-induced apoptosis by suppressing reactive oxygen
species. Cell 119:529–542
Richards TD, Pitts KR, Watt GD (1996) A kinetic study of iron release from Azotobacter
vinelandii bacterial ferritin, J Inorg Biochem 61:1–13
Rodriguez N, Menendez N, Tornero J, Amils R, de la Fuente V (2005) Internal iron biomineralization in Imperata cylindrica, a perennial grass: chemical composition, speciation and plant
localization. New Phytol 165:781–789
Rohrer JS, Islam QT, Watt GD, Sayers DE, Theil EC (1990) Iron environment in ferritin with large
amounts of phosphate, from Azotobacter vinelandii and horse spleen, analyzed using extended
x-ray absorption fine structure (EXAFS). Biochemistry 29:259–264
Schwartz JK, Liu XS, Tosha T, Theil EC, Solomon EI (2008) Spectroscopic definition of the
ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sites. J Am
Chem Soc 130:9441–9450
Semenza GL (2009) Involvement of oxygen-sensing pathways in physiologic and pathologic
erythropoiesis. Blood 114:2015–2019
46
L.E. Bevers and E.C. Theil