Contents XXI
Part C Marine Genomics
17 Marine Sponge Metagenomics
Valliappan Karuppiah, Zhiyong Li .............................................
457
17.1 Background and Problems of Sponge Research .......................
457
17.2 The Principle of Metagenomics and Related Techniques.............
460
17.3 Application and Latest Progress in Sponge Metagenomics...........
465
17.4 Future Perspectives......................................................
469
References .......................................................................
470
18 Proteomics: Applications and Advances
Vernon E. Coyne..................................................................
475
18.1 Omics .....................................................................
475
18.2 Overview of Proteomics Techniques ...................................
476
18.3 Proteomics and Marine Biotechnology ................................
477
18.4 Aquaculture ..............................................................
478
18.5 Environment .............................................................
482
18.6 Natural Products.........................................................
486
18.7 Algal Toxins ..............................................................
488
18.8 Conclusion ...............................................................
490
References .......................................................................
491
19 Marine Metagenome and Supporting Technology
Tetsushi Mori, Haruko Takeyama ...............................................
497
19.1 Bacteria and Marine Ecosystems .......................................
497
19.2 Technologies Supporting Metagenomic Research .....................
502
19.3 Summary .................................................................
505
References .......................................................................
505
20 Microfluidic Systems for Marine Biotechnology
Morgan Hamon, Jing Dai, Sachin Jambovane, Jong W. Hong...............
509
20.1 Basic Principal of Microfluidics .........................................
510
20.2 Microfluidic Devices for Marine Biology and Ecosystem Studies .....
511
20.3 Microfluidic Devices for Sea-Related Health and Safety .............
517
20.4 Microfluidic Systems for Other Marine Biotechnology Applications .
521
20.5 Conclusion ...............................................................
524
References .......................................................................
524
21 Genome Mining for Bioactive Compounds
Soumya Haldar, Kalpana H. Mody .............................................
531
21.1 Overview .................................................................
531
21.2 Temporary Halt in the Discovery of Bioactive Compounds ...........
533
21.3 Future Directions ........................................................
533
21.4 The Hurdles of Drug Discovery ..........................................
536
21.5 Marine Pharmaceuticals Under Clinical Trials .........................
536
References .......................................................................
538