50
B. Conradt
nable to high throughput screens for drug discovery (Rand and Johnson
1995).
References
Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival.
Science 281: 1322-1326
Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P (1998) Apaf-l
(CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94:727-737
Chao DT, Korsmeyer SJ (1998) Bcl-2 family: regulators of cell death. Annu
Rev ImmunoI16:395-419
Chaudhary D, O'Rourke K, Chinnaiyan AM, Dixit VM (1998) The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease. J Bioi Chern 273: 17708-17712
Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM (l997a) Interaction of
CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275: 1122-1126
Chinnaiyan AM, Chaudhary D, O'Rourke K, Koonin EV, Dixit VM (1997b)
Role ofCED-4 in the activation ofCED-3. Nature 388:728-729
Comadt B, Horvitz HR (1998) The C. elegans protein EGL-l is required for
programmed cell death and interacts with the Bcl-2-like Protein CED-9.
Cell 93:519-529
Coucouvanis EC, Martin GR, Nadeau JH (1995) Genetic approaches for
studying programmed cell death during development of the laboratory
mouse. Methods Cell BioI 46:387-440
Cryns V, Yuan J (1998) Proteases to die for. Genes Dev 12: 1551-1570
del Peso L, Gonzalez VM, Nunez G (1998) Caenorhabditis elegans EGL-l
disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J BioI Chern 273:33495-33500
Desai C, Horvitz HR (1989) Caenorhabditis elegans mutants defective in the
functioning of the motor neurons responsible for egg laying. Genetics
121:703-721
Duvall E, Wyllie AH (1986) Death and the cell. Immunol Today 7:115-119
Edgar BA, Lehner CF (1996) Developmental control of cell cycle regulators: a
fly's perspective. Science 274:1646-1652
Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the
nematode C. elegans. Cell 44:817-829
Ellis RE, Horvitz HR (1991a) Two C. elegans genes control the programmed
deaths of specific cells in the pharynx. Development 112:591-603
B. Conradt
nable to high throughput screens for drug discovery (Rand and Johnson
1995).
References
Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival.
Science 281: 1322-1326
Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P (1998) Apaf-l
(CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94:727-737
Chao DT, Korsmeyer SJ (1998) Bcl-2 family: regulators of cell death. Annu
Rev ImmunoI16:395-419
Chaudhary D, O'Rourke K, Chinnaiyan AM, Dixit VM (1998) The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease. J Bioi Chern 273: 17708-17712
Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM (l997a) Interaction of
CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275: 1122-1126
Chinnaiyan AM, Chaudhary D, O'Rourke K, Koonin EV, Dixit VM (1997b)
Role ofCED-4 in the activation ofCED-3. Nature 388:728-729
Comadt B, Horvitz HR (1998) The C. elegans protein EGL-l is required for
programmed cell death and interacts with the Bcl-2-like Protein CED-9.
Cell 93:519-529
Coucouvanis EC, Martin GR, Nadeau JH (1995) Genetic approaches for
studying programmed cell death during development of the laboratory
mouse. Methods Cell BioI 46:387-440
Cryns V, Yuan J (1998) Proteases to die for. Genes Dev 12: 1551-1570
del Peso L, Gonzalez VM, Nunez G (1998) Caenorhabditis elegans EGL-l
disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J BioI Chern 273:33495-33500
Desai C, Horvitz HR (1989) Caenorhabditis elegans mutants defective in the
functioning of the motor neurons responsible for egg laying. Genetics
121:703-721
Duvall E, Wyllie AH (1986) Death and the cell. Immunol Today 7:115-119
Edgar BA, Lehner CF (1996) Developmental control of cell cycle regulators: a
fly's perspective. Science 274:1646-1652
Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the
nematode C. elegans. Cell 44:817-829
Ellis RE, Horvitz HR (1991a) Two C. elegans genes control the programmed
deaths of specific cells in the pharynx. Development 112:591-603