414
against several types of cancer including breast cancer (Le Corre et al. 2004).
Resveratrol by inducing the expression of several genes such as SIRT 1, SIRT2,
SIRT4, FoxO1 and FoxO3a prevents ageing-related decline in the cardiovascular
system including cholesterol level and inflammatory response.
The demonstrated pharmacological properties of naturally occuring stilbenes
have led to the synthesis of analogues to improve activity. Structural analogues of
resveratrol possess some of the effects of resveratrol and potentially even more
benefits. Pinosylvin is chemically related to resveratrol. Pinosylvin has been studied
because of its anti-cancer, anti-fungal and anti-oxidative properties (Roupe et al.
2006). Removal of the hydroxyl group from resveratrol results in pinosylvin. By
this change pinosylvin is more lipophilic than resveratrol (Perecko et al. 2008).
Piceatannol is a naturally occuring stilbene present in sugarcane, berries, peanuts,
red wines and the skin of grapes.
17.11 Conclusions
Stilbene deserves a lot of interest. It is very important in the field of medicine
because of its activity against various diseases. It is widely present in grape wines.
So moderate consumption of wine can decrease the incidence of cardiovascular
diseases and cancer to a great extent. Stilbenes are gaining importance in clinical
trials where they are used as therapeutic drugs. Numerous studies are being conducted on the topic of stilbenes nowadays. Studies are also being carried out to
discover new stilbenes and their analogues. New discoveries about stilbenes are
giving new openings for advanced research work. With the knowledge of their role
in traditional medicines, researchers are trying to expose their various activities so
that they will be more useful in traditional medicinal system. Although there are
new discoveries in modern medicine, common people always depend on traditional
medicine. So study of these stilbenes will be helpful to make advances in the field
of traditional medicine.
References
Aedin C, Bryan H, Rosa M (2000) Isoflavones, lignans and stilbenes origins, metabolism and
potential importance to human health. J Sci Food Agric 80:1044–1062
Aggarwal BB, Shishodia S (2006) Resveratrol in health and disease. Taylor & Francis, Boca
Raton, p 712
Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G (2006) Inflammation and cancer:
how hot is the link? Biochem Pharmacol 72:1605–1621
Alonso F, Riente P, Yus M (2009) Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes. Eur J Org Chem
34:6034–6042
Barnard MJ, Linter SP (1992) Wine and coronary heart disease. Lancet 340:313–315
Barnard P, Isaac M, Jayant D, Claudine C (1999) Occurrence of resveratrol and pterostilbene in
age-old darakchasava, an ayurvedic medicine from India. J Ethnopharmacol 68:71–76
N. Vijayan et al.
against several types of cancer including breast cancer (Le Corre et al. 2004).
Resveratrol by inducing the expression of several genes such as SIRT 1, SIRT2,
SIRT4, FoxO1 and FoxO3a prevents ageing-related decline in the cardiovascular
system including cholesterol level and inflammatory response.
The demonstrated pharmacological properties of naturally occuring stilbenes
have led to the synthesis of analogues to improve activity. Structural analogues of
resveratrol possess some of the effects of resveratrol and potentially even more
benefits. Pinosylvin is chemically related to resveratrol. Pinosylvin has been studied
because of its anti-cancer, anti-fungal and anti-oxidative properties (Roupe et al.
2006). Removal of the hydroxyl group from resveratrol results in pinosylvin. By
this change pinosylvin is more lipophilic than resveratrol (Perecko et al. 2008).
Piceatannol is a naturally occuring stilbene present in sugarcane, berries, peanuts,
red wines and the skin of grapes.
17.11 Conclusions
Stilbene deserves a lot of interest. It is very important in the field of medicine
because of its activity against various diseases. It is widely present in grape wines.
So moderate consumption of wine can decrease the incidence of cardiovascular
diseases and cancer to a great extent. Stilbenes are gaining importance in clinical
trials where they are used as therapeutic drugs. Numerous studies are being conducted on the topic of stilbenes nowadays. Studies are also being carried out to
discover new stilbenes and their analogues. New discoveries about stilbenes are
giving new openings for advanced research work. With the knowledge of their role
in traditional medicines, researchers are trying to expose their various activities so
that they will be more useful in traditional medicinal system. Although there are
new discoveries in modern medicine, common people always depend on traditional
medicine. So study of these stilbenes will be helpful to make advances in the field
of traditional medicine.
References
Aedin C, Bryan H, Rosa M (2000) Isoflavones, lignans and stilbenes origins, metabolism and
potential importance to human health. J Sci Food Agric 80:1044–1062
Aggarwal BB, Shishodia S (2006) Resveratrol in health and disease. Taylor & Francis, Boca
Raton, p 712
Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G (2006) Inflammation and cancer:
how hot is the link? Biochem Pharmacol 72:1605–1621
Alonso F, Riente P, Yus M (2009) Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes. Eur J Org Chem
34:6034–6042
Barnard MJ, Linter SP (1992) Wine and coronary heart disease. Lancet 340:313–315
Barnard P, Isaac M, Jayant D, Claudine C (1999) Occurrence of resveratrol and pterostilbene in
age-old darakchasava, an ayurvedic medicine from India. J Ethnopharmacol 68:71–76
N. Vijayan et al.