360
14.6 Limitations of Quorum Quenching
1. Quorum quenching might have a detrimental role on nonpathogenic or beneficial
microbes (Uroz et al. 2009)
2. Quorum quenching compounds can be easily proteolyzed and majority of the
quorum quenching compounds are heat sensitive (Tang and Zhang 2014)
3. Some of the bacteria have evolved resistance mechanisms against quorum
quenchers (García-Contreras et al. 2013)
4. Lacking of appropriate delivery system of quorum quenching compounds for
developing antivirulence drugs (Tang and Zhang 2014)
14.7 Competitive Environment to Produce Quorum
Quenching Compounds
We are aware that different organisms develop survival strategies to compete with
each other for space, nutrition, and even their ecological niches. Quorum sensing
has been employed by various organisms for coordination and for other social
engagements between microorganisms. The competition between microorganisms
may force one species to produce anti-quorum sensing compounds against the other
species, which will indirectly control the proliferation of that species whose quorum
sensing process has been disrupted (Tang and Zhang 2014).
14.8 Conclusions
Mechanism of bacterial communication has been studied in vast detail, since the
last decade, but we need to explore more resources for obtaining quorum quenching
compounds in order to provide alternatives for developing antivirulence therapy
against the pathogenic organisms. Marine ecosystem is so vast and it may contain a
lot of hidden compounds which need to be explored. So, the need of the hour is to
put increased efforts in obtaining such molecules/compounds which can help us to
achieve success in eradicating the multidrug resistant pathogens and various other
environmental concerns like membrane biofouling. Apart from the use of this process in medicine, we can look for microorganisms that will help in production of
biochemical, microbial biosensors, etc.
References
Abed RM, Dobretsov S, Al-Fori M, Gunasekera SP, Sudesh K, Paul VJ (2013) Quorum-sensing
inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat. J Ind Microbiol Biotechnol 40:759–772
Adak S, Upadrasta L, Kumar S, Soni R, Banerjee R (2011) Quorum quenching–an alternative
antimicrobial therapeutics. In: Mendez-Vilas (ed) Science against microbial pathogens: communicating current research and technological advances. Formatex Research Center, Badajoz,
pp 586–593
G. Seghal Kiran et al.
14.6 Limitations of Quorum Quenching
1. Quorum quenching might have a detrimental role on nonpathogenic or beneficial
microbes (Uroz et al. 2009)
2. Quorum quenching compounds can be easily proteolyzed and majority of the
quorum quenching compounds are heat sensitive (Tang and Zhang 2014)
3. Some of the bacteria have evolved resistance mechanisms against quorum
quenchers (García-Contreras et al. 2013)
4. Lacking of appropriate delivery system of quorum quenching compounds for
developing antivirulence drugs (Tang and Zhang 2014)
14.7 Competitive Environment to Produce Quorum
Quenching Compounds
We are aware that different organisms develop survival strategies to compete with
each other for space, nutrition, and even their ecological niches. Quorum sensing
has been employed by various organisms for coordination and for other social
engagements between microorganisms. The competition between microorganisms
may force one species to produce anti-quorum sensing compounds against the other
species, which will indirectly control the proliferation of that species whose quorum
sensing process has been disrupted (Tang and Zhang 2014).
14.8 Conclusions
Mechanism of bacterial communication has been studied in vast detail, since the
last decade, but we need to explore more resources for obtaining quorum quenching
compounds in order to provide alternatives for developing antivirulence therapy
against the pathogenic organisms. Marine ecosystem is so vast and it may contain a
lot of hidden compounds which need to be explored. So, the need of the hour is to
put increased efforts in obtaining such molecules/compounds which can help us to
achieve success in eradicating the multidrug resistant pathogens and various other
environmental concerns like membrane biofouling. Apart from the use of this process in medicine, we can look for microorganisms that will help in production of
biochemical, microbial biosensors, etc.
References
Abed RM, Dobretsov S, Al-Fori M, Gunasekera SP, Sudesh K, Paul VJ (2013) Quorum-sensing
inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat. J Ind Microbiol Biotechnol 40:759–772
Adak S, Upadrasta L, Kumar S, Soni R, Banerjee R (2011) Quorum quenching–an alternative
antimicrobial therapeutics. In: Mendez-Vilas (ed) Science against microbial pathogens: communicating current research and technological advances. Formatex Research Center, Badajoz,
pp 586–593
G. Seghal Kiran et al.