232
Naveen CD, Prasanth GK, Sadasivan C, Haridas M (2013) Evaluation of bio-transformed berberine derivatives as anti-inflammatory drugs: an in silico study. Interdiscip Sci: Comput Life Sci
4:268–272. doi:10.1007/s12539-012-0142-9
Oinuma H, Takamura T, Hasegawa T, Nomoto K, Naitoh T, Daiku Y, Hamano S, Kakisawa H,
Minami N (1991) Synthesis and biological evaluation of substituted benzenesulfonamides as
novel potent membrane-bound phospholipase A2 inhibitors. J Med Chem 34:2260–2267
Rao P, Knaus EE (2008) Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci 11:81s–110s
Rao PPN, Amini M, Li H, Habeeb AG, Knaus EE (2003) Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class
of diarylheterocyclic selective cyclooxygenase-2 inhibitors. J Med Chem 46:4872–4882.
doi:10.1021/jm0302391
Rao PNP, Uddin MJ, Knaus EE (2004) Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors. J Med Chem
47:3972–3990. doi:10.1021/jm049939b
Rimon G, Sidhu RS, Lauver DA, Lee JY, Sharma NP, Yuan C, Frieler RA, Trievel RC, Lucchesi
BR, Smith WL (2011) Coxibs interfere with the action of aspirin by binding tightly to one
monomer of cyclooxygenase-1. Proc Natl Acad Sci 107:28–33
Rossi A, Pergola C, Koeberle A, Hoffmann M, Dehm F, Bramanti P, Cuzzocrea S, Werz O,
Sautebin L (2010) The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. Br J Pharmacol 161:555–570.
doi:10.1111/j.1476-5381.2010.00930.x
Rouzer CA, Marnett LJ (2009) Cyclooxygenases: structural and functional insights. J Lipid Res
50:S29–S34. doi:10.1194/jlr.R800042-JLR200
Simmons DL, Botting RM, Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin
synthesis and inhibition. Pharmacol Rev 56:387–437
Snyder DW, Bach NJ, Dillard RD, Draheim SE, Carlson DG, Fox N, Roehm NW, Armstrong
CT, Chang CH, Hartley LW, Johnson LM, Roman CR, Smith AC, Song M, Fleisch JH (1999)
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1Hindol- 4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: a new
class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther 288:1117–1124
Springer DM, Luh BY, Bronson JJ, McElhone KE, Mansuri MM, Gregor KR, Nettleton DO,
Stanley PL, Tramposch KM (2000) Biaryldiacid inhibitors of human s-PLA2 with antiinflammatory activity. Bioorg Med Chem 8:1087–1109
Steinhilber D, Hofmann B (2014) Recent advances in the search for novel 5-lipoxygenase inhibitors. Basic Clin Pharmacol Toxicol 114:70–77
Talley JJ (1999) Selective inhibitors of cyclooxygenase-2 (COX-2). Prog Med Chem Res
36:201–234
Tomy MJ, Dileep KV, Prasanth S, Preethidan DS, Sabu A, Sadasivan C, Haridas M (2014a)
Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation. Appl Biochem
Biotechnol 174:388–397
Tomy MJ, Sharanya CS, Dileep KV, Prasanth S, Sabu A, Sadasivan C, Haridas M (2014b)
Derivatives form better lipoxygenase inhibitors than piperine: In vitro and in silico study. Chem
Biol Drug Des 85:715–721
Tramposch KM, Steiner SA, Stanley PL, Nettleton DO, Franson RC, Lewin AH, Carroll FI (1992)
Novel inhibitor of phospholipase A2 with topical anti-inflammatory activity. Biochem Biophys
Res Commun 189:272–279
Tramposch KM, Chilton FH, Stanley PL, Franson RC, Havens MB, Nettleton DO, Davern LB,
Darling IM, Bonney RJ (1994) Inhibitor of phospholipase A2 blocks eicosanoid and platelet
activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther
271:852–859
Van Breemen RB, Tao Y, Li W (2011) Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale).
Fitoterapia 82:38–43. doi:10.1016/j.fitote.2010.09.004
C.S. Sharanya and M. Haridas
Naveen CD, Prasanth GK, Sadasivan C, Haridas M (2013) Evaluation of bio-transformed berberine derivatives as anti-inflammatory drugs: an in silico study. Interdiscip Sci: Comput Life Sci
4:268–272. doi:10.1007/s12539-012-0142-9
Oinuma H, Takamura T, Hasegawa T, Nomoto K, Naitoh T, Daiku Y, Hamano S, Kakisawa H,
Minami N (1991) Synthesis and biological evaluation of substituted benzenesulfonamides as
novel potent membrane-bound phospholipase A2 inhibitors. J Med Chem 34:2260–2267
Rao P, Knaus EE (2008) Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci 11:81s–110s
Rao PPN, Amini M, Li H, Habeeb AG, Knaus EE (2003) Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class
of diarylheterocyclic selective cyclooxygenase-2 inhibitors. J Med Chem 46:4872–4882.
doi:10.1021/jm0302391
Rao PNP, Uddin MJ, Knaus EE (2004) Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors. J Med Chem
47:3972–3990. doi:10.1021/jm049939b
Rimon G, Sidhu RS, Lauver DA, Lee JY, Sharma NP, Yuan C, Frieler RA, Trievel RC, Lucchesi
BR, Smith WL (2011) Coxibs interfere with the action of aspirin by binding tightly to one
monomer of cyclooxygenase-1. Proc Natl Acad Sci 107:28–33
Rossi A, Pergola C, Koeberle A, Hoffmann M, Dehm F, Bramanti P, Cuzzocrea S, Werz O,
Sautebin L (2010) The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. Br J Pharmacol 161:555–570.
doi:10.1111/j.1476-5381.2010.00930.x
Rouzer CA, Marnett LJ (2009) Cyclooxygenases: structural and functional insights. J Lipid Res
50:S29–S34. doi:10.1194/jlr.R800042-JLR200
Simmons DL, Botting RM, Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin
synthesis and inhibition. Pharmacol Rev 56:387–437
Snyder DW, Bach NJ, Dillard RD, Draheim SE, Carlson DG, Fox N, Roehm NW, Armstrong
CT, Chang CH, Hartley LW, Johnson LM, Roman CR, Smith AC, Song M, Fleisch JH (1999)
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1Hindol- 4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: a new
class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther 288:1117–1124
Springer DM, Luh BY, Bronson JJ, McElhone KE, Mansuri MM, Gregor KR, Nettleton DO,
Stanley PL, Tramposch KM (2000) Biaryldiacid inhibitors of human s-PLA2 with antiinflammatory activity. Bioorg Med Chem 8:1087–1109
Steinhilber D, Hofmann B (2014) Recent advances in the search for novel 5-lipoxygenase inhibitors. Basic Clin Pharmacol Toxicol 114:70–77
Talley JJ (1999) Selective inhibitors of cyclooxygenase-2 (COX-2). Prog Med Chem Res
36:201–234
Tomy MJ, Dileep KV, Prasanth S, Preethidan DS, Sabu A, Sadasivan C, Haridas M (2014a)
Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation. Appl Biochem
Biotechnol 174:388–397
Tomy MJ, Sharanya CS, Dileep KV, Prasanth S, Sabu A, Sadasivan C, Haridas M (2014b)
Derivatives form better lipoxygenase inhibitors than piperine: In vitro and in silico study. Chem
Biol Drug Des 85:715–721
Tramposch KM, Steiner SA, Stanley PL, Nettleton DO, Franson RC, Lewin AH, Carroll FI (1992)
Novel inhibitor of phospholipase A2 with topical anti-inflammatory activity. Biochem Biophys
Res Commun 189:272–279
Tramposch KM, Chilton FH, Stanley PL, Franson RC, Havens MB, Nettleton DO, Davern LB,
Darling IM, Bonney RJ (1994) Inhibitor of phospholipase A2 blocks eicosanoid and platelet
activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther
271:852–859
Van Breemen RB, Tao Y, Li W (2011) Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale).
Fitoterapia 82:38–43. doi:10.1016/j.fitote.2010.09.004
C.S. Sharanya and M. Haridas