184
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years.
J Nat Prod 70:461–477
Norbury CJ, Hickson ID (2001) Cellular responses to DNA damage. Annu Rev Pharmacol Toxicol
41:367–401
Olano C, Méndez C, Salas JA (2009) Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep 26:628–660
Pace NR, Stahl DA, Lane DJ, Olsen GJ (1985) Analyzing natural microbial populations by rRNA
sequences. Adv Microb Ecol 51:4–12
Perry RP (1963) Selective effects of actinomycin D on the intracellular distribution of RNA synthesis in tissue culture cells. Exp Cell Res 29:400–406
Pestova TV et al (2001) Molecular mechanisms of translation initiation in eukaryotes. Proc Natl
Acad Sci U S A 98:7029–7036
Pettit RK (2004) Soil DNA libraries for anticancer drug discovery. Cancer Chemother Pharmacol
54:1–6
Piel J, Hui D, Wen G, Butzke D, Platzer M, Fusetani N, Matsunaga S (2004) Antitumor polyketide
biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.
Proc Natl Acad Sci U S A 101:16222–16227
Reich E, Goldberg I (1964) Actinomycin and nucleic acid function. Prog Nucleic Acid Res Mol
Biol 3:183–234
Sačková V, Kuliková L, Kello M, Uhrinová I, Fedoročko P (2011) Enhanced Antiproliferative and
apoptotic response of HT-29 adenocarcinoma cells to combination of Photoactivated Hypericin
and farnesyltransferase inhibitor manumycin A. Int J Mol Sci 1:8388–8405
Schirmer A, Gadkari R, Reeves CD, Ibrahim F, DeLong EF, Hutchinson CR (2005) Metagenomic
analysis reveals diverse Polyketide synthase gene clusters in microorganisms associated with
the marine sponge Discodermia dissolute. Appl Environ Microbiol 71:4840–4849
Schloss PD, Handelsman J (2003) Biotechnological prospects from metagenomics. J Curr Opin
Biotechnol 14:303–310
Schwartsmann G et al (2002) Anticancer drug discovery and development throughout the world.
J Clin Oncol 18:47–59
She M, Yang H, Sun L, Yeung SC (2006) Redox control of manumycin A-induced apoptosis in
anaplastic thyroid cancer cells: involvement of the xenobiotic apoptotic pathway. Cancer Biol
Ther 5:275–280
Simidu U, Kita-Tsukamoto K, Yasumoto T, Yotsu M (1990) Taxonomy of four marine bacterial
strains that produce tetrodotoxin. Int J Syst Bacteriol 40:331–336
Sobell HM, Jain SC, Sakore TD, Nordman CE (1971) Stereochemistry of actinomycin—DNA
binding. Nature 231:200–205
Thoreen CC et al (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals
rapamycin-resistant functions of mTORC1. J Biol Chem 284:8023–8032
Ventura M, Canchaya C, Tauch A, Chandra G, Fitzgerald GF, Chater KF, Van SD (2007) Genomics
of actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiol Mol Biol
Rev 71:495–548
Wang W, Macaulay RJ (1999) Apoptosis of medulloblastoma cells in vitro follows inhibition of
farnesylation using manumycin A. Int J Cancer 82:430–434
Williams PG, Miller ED, Asolkar RN, Jensen PR, Fenical W (2007) Arenicolides AC, 26- membered ring macrolides from the marine actinomycete Salinispora arenicola. J Org Chem
72:5025–5034
Wullschleger S, Loewith R, Hall MN (2006) TOR signalling in growth and metabolism. Cell
124:471–484
Yang W, Del VK, Urano J, Mitsuzawa H, Tamanoi F (1997) Advances in the development of farnesyltransferase inhibitors: substrate recognition by protein farnesyltransferase. J Cell Biochem
27:12–19
Zhou JM, Zhu XF, Pan QC, Liao DF, Li ZM, Liu ZC (2003) Manumycin induces apoptosis in
human hepatocellular carcinoma HepG2 cells. Int J Mol Med 12:955–959
Zimmermann K, Engeser M BJW, Munro MH, Piel J (2009) Pederintype pathways of uncultivated
bacterial symbionts: analysis of o-methyltransferases and generation of a biosynthetic hybrid.
J Am Chem Soc 131:2780–2781
V.M. Dan and R. Sanawar
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years.
J Nat Prod 70:461–477
Norbury CJ, Hickson ID (2001) Cellular responses to DNA damage. Annu Rev Pharmacol Toxicol
41:367–401
Olano C, Méndez C, Salas JA (2009) Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep 26:628–660
Pace NR, Stahl DA, Lane DJ, Olsen GJ (1985) Analyzing natural microbial populations by rRNA
sequences. Adv Microb Ecol 51:4–12
Perry RP (1963) Selective effects of actinomycin D on the intracellular distribution of RNA synthesis in tissue culture cells. Exp Cell Res 29:400–406
Pestova TV et al (2001) Molecular mechanisms of translation initiation in eukaryotes. Proc Natl
Acad Sci U S A 98:7029–7036
Pettit RK (2004) Soil DNA libraries for anticancer drug discovery. Cancer Chemother Pharmacol
54:1–6
Piel J, Hui D, Wen G, Butzke D, Platzer M, Fusetani N, Matsunaga S (2004) Antitumor polyketide
biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.
Proc Natl Acad Sci U S A 101:16222–16227
Reich E, Goldberg I (1964) Actinomycin and nucleic acid function. Prog Nucleic Acid Res Mol
Biol 3:183–234
Sačková V, Kuliková L, Kello M, Uhrinová I, Fedoročko P (2011) Enhanced Antiproliferative and
apoptotic response of HT-29 adenocarcinoma cells to combination of Photoactivated Hypericin
and farnesyltransferase inhibitor manumycin A. Int J Mol Sci 1:8388–8405
Schirmer A, Gadkari R, Reeves CD, Ibrahim F, DeLong EF, Hutchinson CR (2005) Metagenomic
analysis reveals diverse Polyketide synthase gene clusters in microorganisms associated with
the marine sponge Discodermia dissolute. Appl Environ Microbiol 71:4840–4849
Schloss PD, Handelsman J (2003) Biotechnological prospects from metagenomics. J Curr Opin
Biotechnol 14:303–310
Schwartsmann G et al (2002) Anticancer drug discovery and development throughout the world.
J Clin Oncol 18:47–59
She M, Yang H, Sun L, Yeung SC (2006) Redox control of manumycin A-induced apoptosis in
anaplastic thyroid cancer cells: involvement of the xenobiotic apoptotic pathway. Cancer Biol
Ther 5:275–280
Simidu U, Kita-Tsukamoto K, Yasumoto T, Yotsu M (1990) Taxonomy of four marine bacterial
strains that produce tetrodotoxin. Int J Syst Bacteriol 40:331–336
Sobell HM, Jain SC, Sakore TD, Nordman CE (1971) Stereochemistry of actinomycin—DNA
binding. Nature 231:200–205
Thoreen CC et al (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals
rapamycin-resistant functions of mTORC1. J Biol Chem 284:8023–8032
Ventura M, Canchaya C, Tauch A, Chandra G, Fitzgerald GF, Chater KF, Van SD (2007) Genomics
of actinobacteria: tracing the evolutionary history of an ancient phylum. Microbiol Mol Biol
Rev 71:495–548
Wang W, Macaulay RJ (1999) Apoptosis of medulloblastoma cells in vitro follows inhibition of
farnesylation using manumycin A. Int J Cancer 82:430–434
Williams PG, Miller ED, Asolkar RN, Jensen PR, Fenical W (2007) Arenicolides AC, 26- membered ring macrolides from the marine actinomycete Salinispora arenicola. J Org Chem
72:5025–5034
Wullschleger S, Loewith R, Hall MN (2006) TOR signalling in growth and metabolism. Cell
124:471–484
Yang W, Del VK, Urano J, Mitsuzawa H, Tamanoi F (1997) Advances in the development of farnesyltransferase inhibitors: substrate recognition by protein farnesyltransferase. J Cell Biochem
27:12–19
Zhou JM, Zhu XF, Pan QC, Liao DF, Li ZM, Liu ZC (2003) Manumycin induces apoptosis in
human hepatocellular carcinoma HepG2 cells. Int J Mol Med 12:955–959
Zimmermann K, Engeser M BJW, Munro MH, Piel J (2009) Pederintype pathways of uncultivated
bacterial symbionts: analysis of o-methyltransferases and generation of a biosynthetic hybrid.
J Am Chem Soc 131:2780–2781
V.M. Dan and R. Sanawar