183
Fleming A (1929) On the antibacterial action of cultures of Penicillium, with special reference to
their use in the isolation of B. influenzae. Br J Exp Pathol 10:226–236
Gebauer F, Hentze MW (2004) Molecular mechanisms of translational control. Nat Rev Mol Cell
Biol 5:827–835
Gerner EW, Meyskens FL (2004) Polyamines and cancer: old molecules, new understanding. Nat
Rev Cancer 4:781–792
Gillespie DE, Brady SF, Bettermann AD, Cianciotto NP, Liles MR, Rondon MR, Clardy J,
Goodman RM, Handelsman J (2002) Isolation of antibiotics turbomycin A and B from a
metagenomic library of soil microbial DNA. Appl Environ Microbiol 68:4306–4310
Gingras AC, Raught B, Sonenberg N (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68:913–963
Gokhale RS, Sankaranarayanan R, Mohanty D (2007) Versatility of polyketide synthases in generating metabolic diversity. Curr Opin Struct Biol 17:736–743
Goldberg IH, Rabinowitz M, Reich E (1962) Basis of actinomycin action, i. DNA binding and
inhibition of RNA-polymerase synthetic reactions by actinomycin. Proc Natl Acad Sci U S A
48:2094–2101
Grever MR, Lozanski G (2011) Modern strategies for hairy cell leukaemia. J Clin Oncol
29:583–590
Haddadin R (2010) Combination of manumycin A and Mebendazole in human breast cancer
cell lines. A dissertation presented to the Faculty of the Department of Pharmacological and
Pharmaceutical Sciences College of Pharmacy, University of Houston
Hale K, Hummersone M, Manaviazar S, Frigerio M (2002) The chemistry and biology of the
bryostatin antitumour macrolides. Nat Prod Rep 19:413–453
Hara M, Akasaka K, Akinaga S, Okabe M, Nakano H, Gomez R, Wood D, Uh M, Tamanoi F
(1993) Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl
Acad Sci U S A 90:2281–2285
Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926–1945
Hill RT, Enticknap J, Rao KV, Hamann MT (2007) Kahalalide-producing bacteria. US patent
20070196901
Jeandet P, Vasserot Y, Chastang T, Courot E (2013). Engineering microbial cells for the biosynthesis of natural compounds of pharmaceutical significance. BioMed Research International.
Article ID 780145. doi:10.1155/2013/780145
Jimeno J, Faircloth G, Fern’andez Sousa-Faro JM, Scheuer P, Rinehart K (2004) New marine
derived anticancer therapeutics—a journey from the sea to clinical trials. Mar Drugs 2:14–29
Johnston JB (2011) Mechanism of action of pentostatin and cladribine in hairy cell leukaemia.
Leuk Lymphoma 52:43–45
Kathiresan K, Duraisamy A (2005) Current issue of marine microbiology. ENVIS Centre
Newsletters 4:3–5
Kathiresan K, Nabeel MA, Manivannan S (2008) Bioprospecting of marine organisms for novel
bioactive compounds. Sci Trans Environ Technov 1:107–120
Kaul A, Maltese WA (2009) Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. Neoplasia 11:823–834
Kodama M, Ogata T, Sato S (1988) Bacterial production of saxitoxin. Agric Biol Chem
52:1075–1077
Kortmansky J, Schwartz GK (2003) Bryostatin-1: a novel PKC inhibitor in clinical development.
Cancer Investig 21:924–936
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y (2009) Dynamics and diversity in autophagy
mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10:458–467
Nelson TJ, Alkon DL (2009) Neuroprotective versus tumorigenic protein kinase C activators.
Trends Biochem Sci 34:136–145
7 Anti Cancer Agents from Microbes
Fleming A (1929) On the antibacterial action of cultures of Penicillium, with special reference to
their use in the isolation of B. influenzae. Br J Exp Pathol 10:226–236
Gebauer F, Hentze MW (2004) Molecular mechanisms of translational control. Nat Rev Mol Cell
Biol 5:827–835
Gerner EW, Meyskens FL (2004) Polyamines and cancer: old molecules, new understanding. Nat
Rev Cancer 4:781–792
Gillespie DE, Brady SF, Bettermann AD, Cianciotto NP, Liles MR, Rondon MR, Clardy J,
Goodman RM, Handelsman J (2002) Isolation of antibiotics turbomycin A and B from a
metagenomic library of soil microbial DNA. Appl Environ Microbiol 68:4306–4310
Gingras AC, Raught B, Sonenberg N (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68:913–963
Gokhale RS, Sankaranarayanan R, Mohanty D (2007) Versatility of polyketide synthases in generating metabolic diversity. Curr Opin Struct Biol 17:736–743
Goldberg IH, Rabinowitz M, Reich E (1962) Basis of actinomycin action, i. DNA binding and
inhibition of RNA-polymerase synthetic reactions by actinomycin. Proc Natl Acad Sci U S A
48:2094–2101
Grever MR, Lozanski G (2011) Modern strategies for hairy cell leukaemia. J Clin Oncol
29:583–590
Haddadin R (2010) Combination of manumycin A and Mebendazole in human breast cancer
cell lines. A dissertation presented to the Faculty of the Department of Pharmacological and
Pharmaceutical Sciences College of Pharmacy, University of Houston
Hale K, Hummersone M, Manaviazar S, Frigerio M (2002) The chemistry and biology of the
bryostatin antitumour macrolides. Nat Prod Rep 19:413–453
Hara M, Akasaka K, Akinaga S, Okabe M, Nakano H, Gomez R, Wood D, Uh M, Tamanoi F
(1993) Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl
Acad Sci U S A 90:2281–2285
Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926–1945
Hill RT, Enticknap J, Rao KV, Hamann MT (2007) Kahalalide-producing bacteria. US patent
20070196901
Jeandet P, Vasserot Y, Chastang T, Courot E (2013). Engineering microbial cells for the biosynthesis of natural compounds of pharmaceutical significance. BioMed Research International.
Article ID 780145. doi:10.1155/2013/780145
Jimeno J, Faircloth G, Fern’andez Sousa-Faro JM, Scheuer P, Rinehart K (2004) New marine
derived anticancer therapeutics—a journey from the sea to clinical trials. Mar Drugs 2:14–29
Johnston JB (2011) Mechanism of action of pentostatin and cladribine in hairy cell leukaemia.
Leuk Lymphoma 52:43–45
Kathiresan K, Duraisamy A (2005) Current issue of marine microbiology. ENVIS Centre
Newsletters 4:3–5
Kathiresan K, Nabeel MA, Manivannan S (2008) Bioprospecting of marine organisms for novel
bioactive compounds. Sci Trans Environ Technov 1:107–120
Kaul A, Maltese WA (2009) Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress. Neoplasia 11:823–834
Kodama M, Ogata T, Sato S (1988) Bacterial production of saxitoxin. Agric Biol Chem
52:1075–1077
Kortmansky J, Schwartz GK (2003) Bryostatin-1: a novel PKC inhibitor in clinical development.
Cancer Investig 21:924–936
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y (2009) Dynamics and diversity in autophagy
mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10:458–467
Nelson TJ, Alkon DL (2009) Neuroprotective versus tumorigenic protein kinase C activators.
Trends Biochem Sci 34:136–145
7 Anti Cancer Agents from Microbes