167
Consortium MGS (2002) Initial sequencing and comparative analysis of the mouse genome.
Nature 420:520–562
Danielsen S, Lundqvist H (2008) Bacterial alpha-amylase variants, WO Patent 2008/000825
DiCosimo R, McAuliffe J, Poulose AJ, Bohlmann G (2013) Industrial use of immobilized
enzymes. Chem Soc Rev 42:6437–6474
Fernandez-Alvaro E, Snajdrova R, Jochens H, Davids T, Bottcher D, Bornscheuer UT (2011) A
combination of in vivo selection and cell sorting for the identification of enantioselective biocatalysts. Angew Chem Int Ed Engl 50:8584–8587
Ferrer M, Beloqui A, Timmis KN, Golyshin PN (2009) Metagenomics for mining new genetic
resources of microbial communities. J Mol Microbiol Biotechnol 16:109–123
Filice M, Marciello M (2013) Enzymatic synthesis of oligosaccharides: a powerful tool for a sweet
challenge. Curr Org Chem 17:701–718
Hasan F, Shah AA, Hameed A (2006) Industrial applications of microbial lipases. Enzym Microb
Technol 39:235–251
Heird WC (2001) The role of polyunsaturated fatty acids in term and preterm infants and breastfeeding mothers. Pediatr Clin N Am 48:173–188
Hilvert D (2001) Enzyme engineering. CHIMIA Int J Chem 55:867–869
Hohne M, Schatzle S, Jochens H, Robins K, Bornscheuer UT (2010) Rational assignment of key
motifs for function guides in silico enzyme identification. Nat Chem Biol 6:807–813
Holmberg N, Ryde U, Bulow L (1999) Redesign of the coenzyme specificity in L-lactate dehydrogenase from Bacillus stearothermophilus using site-directed mutagenesis and media engineering. Protein Eng 12:851–856
Jaeger KE, Eggert T (2002) Lipases for biotechnology. Curr Opin Biotechnol 13:390–397
Jochens H, Bornscheuer UT (2010) Natural diversity to guide focused directed evolution.
Chembiochem 11:1861–1866
Kazlauskas RJ, Bornscheuer UT (2009) Finding better protein engineering strategies. Nat Chem
Biol 5:526–529
Lei S, Xu Y, Fan G, Xiao M, Pan S (2011) Immobilization of naringinase on mesoporous molecular sieve MCM-41 and its application to debittering of white grapefruit. Appl Surf Sci
257:4096–4099
Mattanovich D, Borth N (2006) Applications of cell sorting in biotechnology. Microb Cell
Factories 5:12
McDonald TJ, Svedruzic D, Kim YH, Blackburn JL, Zhang SB, King PW, Heben MJ (2007)
Wiring-up hydrogenase with single-walled carbon nanotubes. Nano Lett 7:3528–3534
Meng H, Liu P, Sun H, Cai Z, Zhou J, Lin J, Li Y (2016) Engineering a d-lactate dehydrogenase
that can super-efficiently utilize NADPH and NADH as cofactors. Sci Rep 6:24887
Mohamad NR, Marzuki NH, Buang NA, Huyop F, Wahab RA (2015) An overview of technologies for immobilization of enzymes and surface analysis techniques for immobilized enzymes.
Biotechnol Biotechnol Equip 29:205–220
Ogawa K, Moon JH, Guo W, Yagi A, Watanabe N, Sakata K (1995) A study on tea aroma formation mechanism: alcoholic aroma precursor amounts and glycosidase activity in parts of the tea
plant. Zeitschrift für Naturforschung C 50:493–498
Ottesen M, Svendsen I (1970) The subtilisins. In: Methods in enzymology, vol 19. Academic,
New York, pp 199–215
Palackal N, Brennan Y, Callen WN, Dupree P, Frey G, Goubet F, Hazlewood GP, Healey S, Kang
YE, Kretz KA, Lee E, Tan X, Tomlinson GL, Verruto J, Wong VW, Mathur EJ, Short JM,
Robertson DE, Steer BA (2004) An evolutionary route to xylanase process fitness. Protein Sci
13:494–503
Park HS, Nam SH, Lee JK, Yoon CN, Mannervik B, Benkovic SJ, Kim HS (2006) Design and
evolution of new catalytic activity with an existing protein scaffold. Science 311:535–538
Pedersen S, Jensen BF, Jørgensen ST (1995) Enzymes from genetically modified microorganisms,
genetically modified foods. Am Chem Soc 605:196–208
Puri M, Kaur H, Kennedy JF (2005) Covalent immobilization of naringinase for the transformation
of a flavonoid. J Chem Technol Biotechnol 80:1160–1165
6 Enzyme Engineering
Consortium MGS (2002) Initial sequencing and comparative analysis of the mouse genome.
Nature 420:520–562
Danielsen S, Lundqvist H (2008) Bacterial alpha-amylase variants, WO Patent 2008/000825
DiCosimo R, McAuliffe J, Poulose AJ, Bohlmann G (2013) Industrial use of immobilized
enzymes. Chem Soc Rev 42:6437–6474
Fernandez-Alvaro E, Snajdrova R, Jochens H, Davids T, Bottcher D, Bornscheuer UT (2011) A
combination of in vivo selection and cell sorting for the identification of enantioselective biocatalysts. Angew Chem Int Ed Engl 50:8584–8587
Ferrer M, Beloqui A, Timmis KN, Golyshin PN (2009) Metagenomics for mining new genetic
resources of microbial communities. J Mol Microbiol Biotechnol 16:109–123
Filice M, Marciello M (2013) Enzymatic synthesis of oligosaccharides: a powerful tool for a sweet
challenge. Curr Org Chem 17:701–718
Hasan F, Shah AA, Hameed A (2006) Industrial applications of microbial lipases. Enzym Microb
Technol 39:235–251
Heird WC (2001) The role of polyunsaturated fatty acids in term and preterm infants and breastfeeding mothers. Pediatr Clin N Am 48:173–188
Hilvert D (2001) Enzyme engineering. CHIMIA Int J Chem 55:867–869
Hohne M, Schatzle S, Jochens H, Robins K, Bornscheuer UT (2010) Rational assignment of key
motifs for function guides in silico enzyme identification. Nat Chem Biol 6:807–813
Holmberg N, Ryde U, Bulow L (1999) Redesign of the coenzyme specificity in L-lactate dehydrogenase from Bacillus stearothermophilus using site-directed mutagenesis and media engineering. Protein Eng 12:851–856
Jaeger KE, Eggert T (2002) Lipases for biotechnology. Curr Opin Biotechnol 13:390–397
Jochens H, Bornscheuer UT (2010) Natural diversity to guide focused directed evolution.
Chembiochem 11:1861–1866
Kazlauskas RJ, Bornscheuer UT (2009) Finding better protein engineering strategies. Nat Chem
Biol 5:526–529
Lei S, Xu Y, Fan G, Xiao M, Pan S (2011) Immobilization of naringinase on mesoporous molecular sieve MCM-41 and its application to debittering of white grapefruit. Appl Surf Sci
257:4096–4099
Mattanovich D, Borth N (2006) Applications of cell sorting in biotechnology. Microb Cell
Factories 5:12
McDonald TJ, Svedruzic D, Kim YH, Blackburn JL, Zhang SB, King PW, Heben MJ (2007)
Wiring-up hydrogenase with single-walled carbon nanotubes. Nano Lett 7:3528–3534
Meng H, Liu P, Sun H, Cai Z, Zhou J, Lin J, Li Y (2016) Engineering a d-lactate dehydrogenase
that can super-efficiently utilize NADPH and NADH as cofactors. Sci Rep 6:24887
Mohamad NR, Marzuki NH, Buang NA, Huyop F, Wahab RA (2015) An overview of technologies for immobilization of enzymes and surface analysis techniques for immobilized enzymes.
Biotechnol Biotechnol Equip 29:205–220
Ogawa K, Moon JH, Guo W, Yagi A, Watanabe N, Sakata K (1995) A study on tea aroma formation mechanism: alcoholic aroma precursor amounts and glycosidase activity in parts of the tea
plant. Zeitschrift für Naturforschung C 50:493–498
Ottesen M, Svendsen I (1970) The subtilisins. In: Methods in enzymology, vol 19. Academic,
New York, pp 199–215
Palackal N, Brennan Y, Callen WN, Dupree P, Frey G, Goubet F, Hazlewood GP, Healey S, Kang
YE, Kretz KA, Lee E, Tan X, Tomlinson GL, Verruto J, Wong VW, Mathur EJ, Short JM,
Robertson DE, Steer BA (2004) An evolutionary route to xylanase process fitness. Protein Sci
13:494–503
Park HS, Nam SH, Lee JK, Yoon CN, Mannervik B, Benkovic SJ, Kim HS (2006) Design and
evolution of new catalytic activity with an existing protein scaffold. Science 311:535–538
Pedersen S, Jensen BF, Jørgensen ST (1995) Enzymes from genetically modified microorganisms,
genetically modified foods. Am Chem Soc 605:196–208
Puri M, Kaur H, Kennedy JF (2005) Covalent immobilization of naringinase for the transformation
of a flavonoid. J Chem Technol Biotechnol 80:1160–1165
6 Enzyme Engineering