28
J. Gomes and A.S. Menawat
400
12
o
o~
300
200
100
0 v
'
0
0
24
48
72
96
120
144
I
I
%
%
9
\
O\
Time (h)
9
_.--,,
o
o
3 ~
Fig. 9. Fed-batch bioproduction of spectinomycin with glucose feed concentration of 100 g1-1
9 glucose concentration; 9 spectinomycin concentration; -- model fit for spectinomycin concentration; ---- model fit for glucose concentration
400
12
o~
9
X
300
"~
I
200
100
I
I
9
I
I
~o
v v
9 :j~O
,,9
0 a i'~----9149 ,
,
, ......... ,
,
n
,
.
24
48
72
96
120
Time (h)
-2
g
rj
4 8
9
'
0
144
Fig. 10. Fed-batch bioproduction of spectinomycin with glucose feed concentration of 125 g1-1.
9 glucose concentration; 9 spectinomycin concentration; -- model fit for spectinomycin concentration; ---- model fit for glucose concentration